phosphatases
phosphatases(磷酸酶)
Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.
phosphatases 相关产品(102)
- GC10594Sodium FluorideCAS: 7681-49-4纯度: >98.00% / >99.00%
Sodium Fluoride作为氟的另一种形式，经口服后可蓄积于生殖器官，干扰激素调控并激活氧化应激通路，从而导致生殖毒性。
- GC11806β-Glycerophosphate (sodium salt hydrate)CAS: 13408-09-8纯度: >98.00%
An inhibitor of alkaline phosphatase
- GC13941Cyclosporin ACAS: 59865-13-3纯度: >98.00% / >97.00% / >99.00%
Cyclosporin A是一种免疫抑制剂，其主要的三个靶点是亲环蛋白、钙调神经磷酸酶和转运蛋白，其抑制亲环蛋白A和钙调神经磷酸酶活性的IC 50 分别为360nM和5nM。
- GC14368Sodium OrthovanadateCAS: 13721-39-6纯度: >98.00% / >99.00%
A protein tyrosine phosphatase inhibitor
- GC14520(-)-p-Bromotetramisole OxalateCAS: 62284-79-1纯度: >99.50% / >98.00% / >99.00%
(-)-P-Bromotetramisole Oxalate是一种有效的非特异性碱性磷酸酶抑制剂。
- GC16233Tacrolimus (FK506)CAS: 104987-11-3纯度: >99.90% / >98.00%
他克莫司 (FK506) 是一种具有强效免疫抑制作用的大环内酯类抗生素，从筑波链霉菌中分离出来，以前曾用于预防人类同种异体移植和治疗自身免疫性疾病。
- GC17591D-erythro-Sphingosine (synthetic)CAS: 123-78-4纯度: >98.00%
D-erythro-sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶激活剂，EC50 值为 8μM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC10019 | SF1670 | 345630-40-2 | >98.00% | |
SF1670是一种有效的特异性PTEN（第10号染色体上缺失的磷酸酶和张力蛋白同源物）抑制剂。 | ||||
| GC10169 | NSC 87877 | 56990-57-9 | >98.00% | |
A potent inhibitor of SHP-1 and SHP-2 | ||||
| GC10594 | Sodium Fluoride | 7681-49-4 | >98.00% / >99.00% | |
Sodium Fluoride作为氟的另一种形式，经口服后可蓄积于生殖器官，干扰激素调控并激活氧化应激通路，从而导致生殖毒性。 | ||||
| GC10850 | ML-095 (hydrochloride) | 1135318-57-8 | - | |
A PLAP inhibitor | ||||
| GC11352 | Tetramisole HCl | 5086-74-8 | >99.00% | |
Tetramisole HCl 是一种碱性磷酸酶抑制剂，是一种高纯度的抗寄生虫药。 | ||||
| GC11561 | NSC 95397 | 93718-83-3 | >98.00% | |
An irreversible inhibitor of Cdc25 isoforms | ||||
| GC11806 | β-Glycerophosphate (sodium salt hydrate) | 13408-09-8 | >98.00% | |
An inhibitor of alkaline phosphatase | ||||
| GC12020 | TCS 401 | 243966-09-8 | >98.00% | |
A selective PTP1B inhibitor | ||||
| GC12093 | Sodium tartrate | 868-18-8 | >98.00% | |
酒石酸钠是一种具有抗氧化活性的 pH 调节剂。 | ||||
| GC12189 | LB-100 | 1026680-07-8 | - | |
A PP2A inhibitor with anticancer activity | ||||
| GC12306 | Imidazole | 288-32-4 | >99.50% | |
咪唑是一个平面五元环。 | ||||
| GC12880 | GSK 2830371 | 1404456-53-6 | >98.50% | |
An inhibitor of Wip1 phosphatase | ||||
| GC13516 | AS 1949490 | 1203680-76-5 | >98.00% | |
A selective SHIP2 inhibitor | ||||
| GC13941 | Cyclosporin A | 59865-13-3 | >98.00% / >97.00% / >99.00% | |
Cyclosporin A是一种免疫抑制剂，其主要的三个靶点是亲环蛋白、钙调神经磷酸酶和转运蛋白，其抑制亲环蛋白A和钙调神经磷酸酶活性的IC 50 分别为360nM和5nM。 | ||||
| GC14321 | Sal 003 | 1164470-53-4 | >99.50% | |
An inhibitor of eIF2α dephosphorylation | ||||
| GC14368 | Sodium Orthovanadate | 13721-39-6 | >98.00% / >99.00% | |
A protein tyrosine phosphatase inhibitor | ||||
| GC14520 | (-)-p-Bromotetramisole Oxalate | 62284-79-1 | >99.50% / >98.00% / >99.00% | |
(-)-P-Bromotetramisole Oxalate是一种有效的非特异性碱性磷酸酶抑制剂。 | ||||
| GC14875 | NSC 663284 | 383907-43-5 | >99.50% | |
Inhibitor of Cdc25 isoforms | ||||
| GC16233 | Tacrolimus (FK506) | 104987-11-3 | >99.90% / >98.00% | |
他克莫司 (FK506) 是一种具有强效免疫抑制作用的大环内酯类抗生素，从筑波链霉菌中分离出来，以前曾用于预防人类同种异体移植和治疗自身免疫性疾病。 | ||||
| GC16256 | BVT 948 | 39674-97-0 | >98.50% | |
An inhibitor of protein tyrosine phosphatases | ||||
| GC16396 | Sodium molybdate | 7631-95-0 | - | |
钼酸钠（钼酸二钠）是一种有用的钼酸盐来源。 | ||||
| GC16451 | L-690330 | 142523-38-4 | >98.00% | |
L-690,330 是一种肌醇单磷酸酶 (IMPase) 的竞争性抑制剂，对重组人和牛 IMPase 的 Kis 分别为 0.27 和 0.19 μM，对人和牛额叶皮层 IMPase 的 Kis 分别为 0.30 和 0.42 μM。 | ||||
| GC17331 | Salubrinal | 405060-95-9 | >99.50% | |
Salubrinal是有效的选择性真核翻译起始因子2α（eIF2α）去磷酸化抑制剂。 | ||||
| GC17591 | D-erythro-Sphingosine (synthetic) | 123-78-4 | >98.00% | |
D-erythro-sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶激活剂，EC50 值为 8μM。 | ||||