phosphatases
phosphatases(磷酸酶)
Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.
phosphatases 相关产品(102)
- GC38919KY-226CAS: 1621673-53-7纯度: >98.00%
KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively.
- GC44226MLS-0322825 Cmpd 23CAS: 1908414-82-3纯度: >98.00%
MLS-0322825 Cmpd 23 是一种低分子量蛋白酪氨酸磷酸酶 (LMPTP) 的选择性抑制剂，IC50 为 0.8 μM LMPTP-A。
- GC48509Apigenin 7-O-Glucuronide (hydrate)纯度: >95.00%
Apigenin 7-O-glucuronide is a flavonoid that has been found in J
- GC49074ForphenicineCAS: 57784-96-0纯度: >90.00%
A bacterial metabolite and an inhibitor of alkaline phosphatase
- GC491693,8’-BiapigeninCAS: 101140-06-1纯度: >98.00%
A biflavonoid with diverse biological activities
- GC49401Triptolide-d3纯度: >99.00%
Triptolide-d3 (PG490-d3) 是氘标记的雷公藤内酯。雷公藤内酯是从雷公藤根中提取的二萜类三环氧化物，具有免疫抑制、抗炎、抗增殖和抗肿瘤作用。雷公藤内酯是一种 NF-κB 活化抑制剂。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC38916 | GNF362 | 1003019-41-7 | >99.00% | |
GNF362 是肌醇三磷酸3'激酶 B (Itpkb) 的选择性，有效且可口服生物利用的抑制剂，IC50为 9 nM。 GNF362 还抑制 Itpka 和 Itpkc，IC50 值分别为 20 nM 和 19 nM。 肌醇三磷酸3'激酶 B (Itpkb) 是一种 Ca2+ 依赖性激酶，其磷酸化 Ins (1,4,5) P3 的 3' 位置，生成肌醇 1,3,4,5-四磷酸 [Ins (1,3,4,5) P4]。 | ||||
| GC38919 | KY-226 | 1621673-53-7 | >98.00% | |
KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. | ||||
| GC39160 | BCI-215 | 1245792-67-9 | >98.00% | |
BCI-215 是一种高效、肿瘤细胞选择性的双重特异性磷酸酶 DUSP-MKP 抑制剂。BCI-215 对肿瘤细胞有细胞毒性，但对正常细胞无毒性。 | ||||
| GC39514 | TNO155 | 1801765-04-7 | >99.00% | |
A SHP-2 inhibitor | ||||
| GC41305 | DA-3003-2 | 383907-47-9 | >98.00% | |
A Cdc25 phosphatase inhibitor | ||||
| GC41443 | TAN 1364B | 154639-24-4 | >95.00% | |
A PTP inhibitor | ||||
| GC44226 | MLS-0322825 Cmpd 23 | 1908414-82-3 | >98.00% | |
MLS-0322825 Cmpd 23 是一种低分子量蛋白酪氨酸磷酸酶 (LMPTP) 的选择性抑制剂，IC50 为 0.8 μM LMPTP-A。 | ||||
| GC44637 | PHPS1 | 314291-83-3 | >98.00% | |
PHPS1是一种细胞通透性、磷酸酪氨酸类似物，能够选择性抑制含Src同源结构域的磷酸酶（SHP2），IC 50 值为2.1μM，K i 值为0.73μM。 | ||||
| GC44774 | PTP Inhibitor III | 29936-81-0 | >95.00% | |
A general PTP inhibitor | ||||
| GC44775 | PTP1B Inhibitor | 765317-72-4 | >98.00% | |
A cell-permeable allosteric inhibitor of PTP1B | ||||
| GC44887 | SHP099 | 1801747-42-1 | >99.50% | |
SHP099是一种高效、选择性、口服生物可利用的SHP2抑制剂，IC 50 值为0.071μM。 | ||||
| GC45149 | VK3-OCH3 | 255906-59-3 | >98.00% | |
An analog of vitamin K 3 | ||||
| GC46011 | SPI 112 | 1051387-90-6 | >98.00% | |
A cell-impermeable SHP-2 inhibitor | ||||
| GC46897 | AUTEN-99 | 1049780-58-6 | >98.00% | |
An inhibitor of MRMR14/Jumpy | ||||
| GC47674 | Mifepristone-d3 | - | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC48509 | Apigenin 7-O-Glucuronide (hydrate) | - | >95.00% | |
Apigenin 7-O-glucuronide is a flavonoid that has been found in J | ||||
| GC49074 | Forphenicine | 57784-96-0 | >90.00% | |
A bacterial metabolite and an inhibitor of alkaline phosphatase | ||||
| GC49169 | 3,8’-Biapigenin | 101140-06-1 | >98.00% | |
A biflavonoid with diverse biological activities | ||||
| GC49401 | Triptolide-d3 | - | >99.00% | |
Triptolide-d3 (PG490-d3) 是氘标记的雷公藤内酯。雷公藤内酯是从雷公藤根中提取的二萜类三环氧化物，具有免疫抑制、抗炎、抗增殖和抗肿瘤作用。雷公藤内酯是一种 NF-κB 活化抑制剂。 | ||||
| GC49403 | Benzarone | 1477-19-6 | >98.00% | |
An active metabolite of benzbromarone | ||||
| GC49494 | 4-Aminobenzylphosphonic Acid | 5424-27-1 | >95.00% | |
An alkaline phosphatase inhibitor | ||||
| GC50041 | VO-OHpic | 675848-25-6 | - | |
A specific inhibitor of PTEN | ||||
| GC50357 | CX08005 | 1256341-22-6 | - | |
Competitive PTP1B inhibitor | ||||
| GC50568 | PHPS1 sodium salt | - | - | |
A selective SHP-2 inhibitor | ||||