ML-095 (hydrochloride) is a specific PLAP inhibitor [1].
Alkaline phosphatases are hydrolase enzymes responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. There are three isozymes of alkaline phosphatases: placental alkaline phosphatase (PLAP), intestinal alkaline phosphatase (IAP), and tissue non-specific alkaline phosphatase (TNAP). Placental alkaline phosphatase (PLAP) is highly expressed in primate placental tissue and the biological function is still unknown. However, PLAP-like enzymes are detected in serum of patients with primary testicular tumors, in particular seminoma and other cancers [1].
ML-095 (CID-25067483) is a biochemical inhibitor of PLAP and will be useful to elucidate the key biological functions and natural substrates of human PLAP. ML095 is a specific PLAP inhibitor and inhibited PLAP, TNAP and IAP with IC50 values of 2.1, >100 and 53 μM, respectively. ML095 exhibited greater than 25-fold selectivity over tissue non-specific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) [1].
Reference:
[1]. Lanier M, Cashman J, Sergienko E, et al. Placental Alkaline Phosphatase (PLAP) Luminescent HTS assay - Probe 2.