MMP
MMP(基质金属蛋白酶)
Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases, generally consisting of a single peptide, a propeptide domain, a catalytic domain with a highly conserved zinc-binding site and a haemopexin-like domain, that catalyze the degradation of all components of the extracellular matrix. Multiple studies have shown that MMPs are overexpressed in malignant tumor and involved in the process of tumor growth, invasion and metastasis. Thus, synthetic and naturally occurring MMP inhibitions have been investigated as anti-cancer agents for the treatment of a variety of cancers, which are divided into three pharmacologic categories, including collagen peptidomimetics and nonpeptidomimetics, tetracycline derivatives and bisphosphonates.
MMP 相关产品(191)
- GC47650Methotrexate-d3CAS: 432545-63-6纯度: >99.00%
An internal standard for the quantification of methotrexate
- GC47712Mycophenolate Mofetil-d4CAS: 1132748-21-0纯度: >99.00%
An internal standard for the quantification of mycophenolate mofetil
- GC47965Pomalidomide-d5CAS: 1377838-49-7纯度: >99.00%
An internal standard for the quantification of pomalidomide
- GC48060Rosuvastatin-d6 (sodium salt)CAS: 2070009-41-3纯度: >98.50%
An internal standard for the quantification of rosuvastatin
- GC48416Chlorhexidine-d8 (hydrochloride)CAS: 2012598-75-1纯度: >99.00%
An internal standard for the quantification of chlorhexidine
- GC48509Apigenin 7-O-Glucuronide (hydrate)纯度: >95.00%
Apigenin 7-O-glucuronide is a flavonoid that has been found in J
- GC60114CTTHWGFTLC, CYCLIC TFA纯度: >98.50%
CTTHWGFTLC,CYCLICTFA是一种基质金属蛋白酶MMP-2和MMP-9的环肽抑制剂。对MMP-9的IC50约为8μM。
- GC62948Edaravone D5CAS: 1228765-67-0
Edaravone D5 是 Edaravone 的氘代标记物。Edaravone 是一种有效的自由基清除剂，能够抑制大鼠与 MMP-9 有关的脑出血。
- GC63132OtaplimastatCAS: 1176758-04-5
Otaplimastat (SP-8203) 是一种基质金属蛋白酶 (MMP) 抑制剂，以竞争方式阻断 NMDA 受体介导的兴奋性毒性。Otaplimastat 还具有抗氧化活性。Otaplimastat 可用于脑缺血损伤的研究。
- GC63621DoxycyclineCAS: 564-25-0纯度: >98.00%
Doxycycline(多西环素DOX)是一种四环素衍生物的广谱抗生素,通过干扰细菌核糖体30S亚基A位点上活化的氨基酰基tRNA的结合来抑制蛋白质合成。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC47648 | Methomyl | 16752-77-5 | >98.00% | |
A carbamate insecticide | ||||
| GC47650 | Methotrexate-d3 | 432545-63-6 | >99.00% | |
An internal standard for the quantification of methotrexate | ||||
| GC47660 | Methyl Parathion | 298-00-0 | >98.00% | |
An organophosphate insecticide | ||||
| GC47712 | Mycophenolate Mofetil-d4 | 1132748-21-0 | >99.00% | |
An internal standard for the quantification of mycophenolate mofetil | ||||
| GC47847 | Oxamyl | 23135-22-0 | >98.00% | |
A carbamate pesticide | ||||
| GC47965 | Pomalidomide-d5 | 1377838-49-7 | >99.00% | |
An internal standard for the quantification of pomalidomide | ||||
| GC48060 | Rosuvastatin-d6 (sodium salt) | 2070009-41-3 | >98.50% | |
An internal standard for the quantification of rosuvastatin | ||||
| GC48093 | Spiromesifen | 283594-90-1 | >95.00% | |
An insecticide and acaricide | ||||
| GC48416 | Chlorhexidine-d8 (hydrochloride) | 2012598-75-1 | >99.00% | |
An internal standard for the quantification of chlorhexidine | ||||
| GC48421 | GW 280264X | 866924-39-2 | >98.00% | |
An ADAM17/TACE and ADAM10 inhibitor | ||||
| GC48509 | Apigenin 7-O-Glucuronide (hydrate) | - | >95.00% | |
Apigenin 7-O-glucuronide is a flavonoid that has been found in J | ||||
| GC49142 | Isorhoifolin | 552-57-8 | >98.00% | |
A flavonoid glycoside with diverse biological activities | ||||
| GC50189 | TAPI 0 | 163958-73-4 | - | |
TAPI 0 是一种 TACE（TNF-α 转化酶；ADAM17）抑制剂，IC50 为 100 nM。 | ||||
| GC50353 | T 26c disodium salt | 869298-22-6 | >98.00% | |
A selective inhibitor of MMP-13 | ||||
| GC60114 | CTTHWGFTLC, CYCLIC TFA | - | >98.50% | |
CTTHWGFTLC,CYCLICTFA是一种基质金属蛋白酶MMP-2和MMP-9的环肽抑制剂。对MMP-9的IC50约为8μM。 | ||||
| GC60860 | FSL-1 TFA | - | >98.00% | |
FSL-1, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection. | ||||
| GC62347 | CMC2.24 | 1255639-43-0 | >96.00% | |
CMC2.24 (TRB-N0224) 是一种口服活性三羰基甲烷制剂，通过抑制 Ras 及其下游效应子 ERK1/2 途径对小鼠胰腺肿瘤有效。CMC2.24 也是一种有效的锌依赖性 MMPs 抑制剂，IC50 范围为 2.0-69 μM。CMC2.24 通过恢复软骨内稳态和通过NF-κB/HIF-2α 轴抑制软骨细胞凋亡来减轻骨关节炎的进展。 | ||||
| GC62948 | Edaravone D5 | 1228765-67-0 | - | |
Edaravone D5 是 Edaravone 的氘代标记物。Edaravone 是一种有效的自由基清除剂，能够抑制大鼠与 MMP-9 有关的脑出血。 | ||||
| GC63132 | Otaplimastat | 1176758-04-5 | - | |
Otaplimastat (SP-8203) 是一种基质金属蛋白酶 (MMP) 抑制剂，以竞争方式阻断 NMDA 受体介导的兴奋性毒性。Otaplimastat 还具有抗氧化活性。Otaplimastat 可用于脑缺血损伤的研究。 | ||||
| GC63322 | MMP13-IN-3 | 1222173-37-6 | - | |
An inhibitor of MMP-13 | ||||
| GC63621 | Doxycycline | 564-25-0 | >98.00% | |
Doxycycline(多西环素DOX)是一种四环素衍生物的广谱抗生素,通过干扰细菌核糖体30S亚基A位点上活化的氨基酰基tRNA的结合来抑制蛋白质合成。 | ||||
| GC63661 | Aderbasib | 791828-58-5 | - | |
Aderbasb (INCB007839) 是一种有效的、具有口服活性的、靶向特异性的低纳摩尔 ADAM10 和 ADAM17 抑制剂。Aderbasb 表现出强大的抗肿瘤活性，可用于癌症研究，包括弥漫性大 B 细胞非霍奇金淋巴瘤，HER2+ 乳腺癌，胶质瘤等。 | ||||
| GC64535 | (S,S)-TAPI-1 | 171235-71-5 | - | |
A TACE inhibitor | ||||
| GC64992 | YH-306 | 1373764-75-0 | >98.00% | |
YH-306 是一种抗肿瘤剂。YH-306 通过 FAK 通路抑制结直肠肿瘤的生长和转移。 YH-306 显着抑制结直肠癌细胞的迁移和侵袭。YH-306 有效抑制不受抑制的增殖并诱导细胞凋亡 (apoptosis)。YH-306 抑制 FAK、c-Src、桩蛋白和 PI3K、Rac1 的激活以及 MMP2 和 MMP9 的表达。YH-306 还抑制肌动蛋白相关蛋白 (Arp2/3) 复合物介导的肌动蛋白聚合。 | ||||