GlpBio

PF-00356231 hydrochloride

目录号: GC38831纯度: >99.50%
PF-00356231 hydrochloride 是一种非肽、非锌螯合的基质金属蛋白酶 MMP-12 的配体和抑制剂 (IC50=1.4 μM)。它对 MMP-12 具有特异性并形成 PF-00356231/MMP-12 复合体。PF-00356231 hydrochloride 对 MMP-13、MMP-8、MMP-9、MMP-3 有抑制作用，IC50 分别为 0.00065、1.7、0.98、0.39 μM。
PF-00356231 hydrochloride
Cas No.: 820223-77-6
规格价格库存数量操作
1mg¥1,035.00现货
1
5mg¥3,015.00现货
1
10mg¥4,410.00现货
1
10mM (in 1mL DMSO)¥3,084.00现货
1
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文献被引

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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    31, 1291–1307 (2021)

产品描述 Description

PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1].

PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). PF-00356231 hydrochloride decreases the IC50 values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH[1].

[1]. Morales R, et al. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J Mol Biol. 2004 Aug 20;341(4):1063-76.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
820223-77-6
SMILES
OC(C[C@H](C1=CC=CC=C1)NC(C2=CC(C3=CC=C(C4=CC=NC=C4)C=C3)=CS2)=O)=O.[H]Cl
分子式
C25H21ClN2O3S
分子量
464.96 g/mol
溶解性
DMSO : 20.83 mg/mL (44.80 mM; ultrasonic and warming and heat to 60°C); H<sub>2</sub>O : &lt; 0.1 mg/mL (insoluble)
保存条件
Store at -20&#176;C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol