CN128 is an orally bioavailable iron chelator.1 It contains a side chain hydroxy group that acts as an alternate sacrificial glucuronidation site to alleviate metabolic inactivation at the 3-hydroxy group. CN128 increases iron mobilization by 24.8% in a 59Fe-ferritin-loaded rat model of iron overload when administered at doses of 150 and 450 ?mol/kg.
1.Chen, W., Yuan, X., Li, Z., et al.CN128: A new orally active hydroxypyridinone iron chelatorJ. Med. Chem.63(8)4215-4226(2020)