Lucidenic acid A is a triterpene originally isolated from G. lucidum and has anticancer activity.1,2 It is cytotoxic to HepG2, HepG2 2.2.15', and P388 cancer cells (IC50s = 0.164, 0.205, and 17 nM, respectively). Lucidenic acid A inhibits increases in matrix metalloproteinase-2 (MMP-2) and MMP-9 activity and Matrigel? invasion induced by phorbol 12-myristate 13-acetate in HepG2 cells.2
1.Wu, T.-S., Shi, L.-S., and Kuo, S.-C.Cytotoxicity of Ganoderma lucidum triterpenesJ. Nat. Prod.64(8)1121-1122(2001) 2.Weng, C.-J., Chau, C.-F., Chen, K.-D., et al.The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strainMol. Nutr. Food Res.51(12)1472-1477(2007)