Decylubiquinone is an analog of ubiquinone . It blocks reactive oxygen species production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition. [1] Decylubiquinone inhibited opening of the mitochondrial permeability transition pore in response to calcium overload in rat liver mitochondria in different cell lines at concentrations between 50-100 µM.[2]
Reference:
[1]. Armstrong, J.S., Whiteman, M., Rose, P., et al. The Coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: Role of mitochondrial complex III. J. Biol. Chem. 278(49), 49079-49084 (2003).
[2]. Devun, F., Walter, L., Belliere, J., et al. Ubiquinone analogs: A mitochondrial permeability transition pore-dependent pathway to selective cell death. PLoS One 5(7), (2010).