Rabeprazole sulfide is an active metabolite of the proton pump inhibitor rabeprazole .1 It inhibits the motility of H. pylori (IC50 = 0.25 ?g/ml).2 Rabeprazole sulfide is cytotoxic to HepG2 liver and PANC-1 pancreatic cancer cells (IC50s = 0.08 and 0.17 ?M, respectively).3 It is also a potential impurity in commercial preparations of rabeprazole and an acid and neutral hydrolytic degradation product of rabeprazole.4,3
1.Cao, N., Liu, L., Hao, Y.-B., et al.Simultaneous determination of rabeprazole enantiomers and their four metabolites after intravenous administration in beagle dogs by a stereoselective HPLC-MS/MS method and its application in pharmacokinetic studiesAnal. Methods81405(2016) 2.Tsutsui, N., Taneike, I., Ohara, T., et al.A novel action of the proton pump inhibitor rabeprazole and its thioether derivative against the motility of Helicobacter pyloriAntimicrob. Agents Chemother.44(11)3069-3073(2000) 3.Bhandi, M.M., Borkar, R.M., Shankar, G., et al.Identification and characterization of stressed degradation products of rabeprazole using LC-ESI/MS/MS and 1H-NMR experiments: In vitro toxicity evaluation of major degradation productsRSC Adv.610719(2016) 4.Reddy, G.M., Bhaskar, B.V., Reddy, P.P., et al.Identification and characterization of potential impurities of rabeprazole sodiumJ. Pharm. Biomed. Anal.43(4)1262-1269(2007)