GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC16744 structure
    GC16744Z-DQMD-FMK

    Caspase-3 inhibitor,cell-permeable

  • GC16887 structure
    GC16887Tegobuvir
    CAS: 1000787-75-6
    纯度: >98.00%

    A non-nucleoside inhibitor of HCV NS5B

  • GC17791 structure
    GC17791LY2811376
    CAS: 1194044-20-6
    纯度: >99.50%

    A BACE1 inhibitor

  • GC12236 structure
    GC12236Daclatasvir dihydrochloride
    CAS: 1009119-65-6
    纯度: >99.50%

    An NS5A inhibitor

  • GC11713 structure
    GC11713Q-VD(OMe)-OPh

    Pan-caspase inhibitor

  • GC14636 structure
    GC14636KW-2478
    CAS: 819812-04-9
    纯度: >98.50%

    An Hsp90 inhibitor

  • GC14937 structure
    GC14937Anguizole
    CAS: 442666-98-0
    纯度: >99.50%

    Anguizole 是一种 HCV 复制的小分子抑制剂，可改变 NS4B 的亚细胞分布。

  • GC16990 structure
    GC16990Z-LEHD-FMK
    CAS: 210345-04-3
    纯度: >98.00%

    Z-LEHD-FMK是一种不可逆的caspase-9抑制剂。

  • GC10155 structure
    GC10155Vaniprevir
    CAS: 923590-37-8

    Vaniprevir (MK-7009) 是丙型肝炎病毒 (HCV) NS3/4A 蛋白酶的非共价竞争性抑制剂。

  • GC10064 structure
    GC10064Flurizan
    CAS: 51543-40-9
    纯度: >99.50%

    A COX-inactive enantiomer of flurbiprofen

  • GC10794 structure
    GC10794BMS-626529
    CAS: 701213-36-7
    纯度: >99.00%

    An HIV-1 attachment inhibitor

  • GC11908 structure
    GC11908Cisplatin
    CAS: 15663-27-1
    纯度: >98.00% / >99.00% / >99.50%

    顺铂是最好的、最早的基于金属的化疗药物之一，用于治疗广泛的实体癌症，如睾丸癌、卵巢癌、膀胱癌、肺癌、宫颈癌、头颈部肿瘤和胃癌等。

  • GC11993 structure
    GC11993PAC-1
    CAS: 315183-21-2
    纯度: >98.00%

    PAC-1是一种具有口服活性的小分子procaspase-3激活剂，可诱导癌细胞凋亡，EC 50 为2.08μM。

  • GC12603 structure
    GC12603DPPI 1c hydrochloride
    CAS: 866396-34-1

    A DPP-4 inhibitor

  • GC12998 structure
    GC12998HIV-1 integrase inhibitor
    CAS: 544467-07-4

    HIV-1整合酶抑制剂可用于抗HIV。

  • GC13337 structure
    GC133374-Chlorophenylguanidine hydrochloride
    CAS: 14279-91-5

    Urokinase inhibitor, potent and specific

  • GC14126 structure
    GC14126NVP DPP 728 dihydrochloride
    CAS: 247016-69-9

    NVP DPP 728 dihydrochloride 是一种有效的、可逆的和腈依赖性二肽基肽酶 IV (DPP-IV) 抑制剂。

  • GC14578 structure
    GC14578GI 254023X
    CAS: 260264-93-5
    纯度: >98.00%

    GI 254023X是一种选择性抑制剂，针对MMP9（Matrix Metalloproteinase 9）的IC 50 值为5.3nM，GI 254023X对ADAM10（A Disintegrin and Metalloproteinase 10）的选择性是ADAM17的100倍，IC 50 值为2.5nM。GI 254023X主要用于免疫学、炎症和神经退行性疾病的研究。

  • GC16431 structure
    GC16431MRK 560
    CAS: 677772-84-8
    纯度: >99.00%

    A potent inhibitor of γ-secretase

  • GC17655 structure
    GC17655Ganetespib (STA-9090)
    CAS: 888216-25-9
    纯度: >99.50%

    Ganetespib (STA-9090) (STA-9090) 是一种热休克蛋白 90 (HSP90) 抑制剂，在多种血液和实体肿瘤细胞系中表现出强效细胞毒性。 Ganetespib (STA-9090) 通过抑制 HIF-1α 在结直肠癌中具有抗血管生成作用；和 STAT3。

  • GC18011 structure
    GC18011SC 57461A
    CAS: 423169-68-0

    A potent, orally active inhibitor of LTA 4 hydrolase

  • GC10802 structure
    GC10802K 579
    CAS: 440100-64-1

    K 579 是一种有效且具有口服活性的二肽基肽酶 IV 抑制剂。

  • GC11300 structure
    GC11300Fosamprenavir Calcium Salt
    CAS: 226700-81-8
    纯度: >98.00%

    A prodrug form of amprenavir

  • GC12358 structure
    GC12358Fumagillin
    CAS: 23110-15-8
    纯度: >95.00%

    A fungal metabolite with diverse biological activities