GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC12659 structure
    GC12659Begacestat
    CAS: 769169-27-9
    纯度: >99.50%

    An inhibitor of γ-secretase

  • GC13885 structure
    GC13885Elesclomol (STA-4783)
    CAS: 488832-69-5
    纯度: >99.00% / >98.00%

    Elesclomol（也称为 STA-4783）最初是在基于细胞的表型筛选中发现的促凋亡活性，是一种新型小分子，可通过快速产生活性氧 (ROS) 有效诱导癌细胞凋亡以及难以控制的氧化应激水平的诱导。

  • GC14084 structure
    GC14084Nelfinavir Mesylate
    CAS: 159989-65-8
    纯度: >99.00%

    An HIV-1 protease inhibitor

  • GC14209 structure
    GC14209Apoptosis Activator 2
    CAS: 79183-19-0
    纯度: >98.00%

    An activator of caspases

  • GC14458 structure
    GC14458Asunaprevir (BMS-650032)
    CAS: 630420-16-5
    纯度: >99.50%

    An HCV NS3/4A protease inhibitor

  • GC14886 structure
    GC14886PETCM
    CAS: 10129-56-3

    PETCM 是 caspase-3 的激活剂，并以细胞色素 c (细胞 c) 依赖性方式发挥作用。 PETCM 促进 Apaf-1 寡聚化并诱导 HeLa 细胞中的细胞凋亡。

  • GC15364 structure
    GC15364L-685,458
    CAS: 292632-98-5
    纯度: >99.00%

    A γ-secretase inhibitor

  • GC15954 structure
    GC15954UK 356618
    CAS: 230961-08-7
    纯度: >98.50%

    An inhibitor of MMP-3

  • GC16434 structure
    GC16434TC-E 5006
    CAS: 1257395-14-4

    γ-secretase modulator

  • GC16844 structure
    GC16844BC 11 hydrobromide
    CAS: 443776-49-6

    Selective urokinase inhibitor

  • GC17989 structure
    GC17989L 006235
    CAS: 294623-49-7
    纯度: >99.50%

    An inibitor of cathepsin K

  • GC10160 structure
    GC10160Apoptosis Inhibitor
    CAS: 54135-60-3
    纯度: >97.50%

    A cell-permeable inhibitor of caspase-3 activation

  • GC10406 structure
    GC10406Tosedostat (CHR2797)
    CAS: 238750-77-1
    纯度: >99.50%

    An aminopeptidase inhibitor

  • GC12465 structure
    GC12465ARP 101
    CAS: 849773-63-3
    纯度: >99.00%

    ARP 101 是一种有效的选择性抑制剂基质金属蛋白酶 2 (MMP-2)。 ARP 101 在癌细胞中诱导自噬相关的细胞死亡。 ARP 101 可有效诱导自噬体的形成和 LC3I 转化为 LC3II。

  • GC12653 structure
    GC12653LY3039478
    CAS: 1421438-81-4
    纯度: >98.00%

    A Notch inhibitor

  • GC13619 structure
    GC13619JLK 6
    CAS: 62252-26-0

    A protease inhibitor

  • GC14099 structure
    GC14099Marimastat
    CAS: 154039-60-8
    纯度: >98.00%

    Marimastat是一种广谱的，具有口服活性的基质金属蛋白酶（MMP）抑制剂，IC 50 值为3~13nM。

  • GC14201 structure
    GC14201PK 44 phosphate
    CAS: 1017682-65-3

    DPP-IV inhibitor

  • GC17247 structure
    GC17247Sivelestat sodium salt
    CAS: 150374-95-1
    纯度: >98.00%

    An inhibitor of neutrophil elastase

  • GC18137 structure
    GC18137Ivachtin
    CAS: 745046-84-8
    纯度: >98.00%

    A reversible caspase-3 inhibitor

  • GC10377 structure
    GC10377SID 26681509
    CAS: 958772-66-2
    纯度: >98.00%

    SID 26681509 是一种有效的、可逆的、竞争性的、选择性的人组织蛋白酶 L 抑制剂，IC50 为 56 nM。

  • GC10998 structure
    GC10998PF-03084014
    CAS: 865773-15-5

    γ-secretase inhibitor

  • GC13171 structure
    GC13171AZ 10417808
    CAS: 331645-84-2

    Caspase-3 inhibitor,selective non-peptide

  • GC15645 structure
    GC15645Compound W
    CAS: 173550-33-9

    A Notch1 signaling modulator