GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC15899 structure
    GC15899MK-0752
    CAS: 471905-41-6
    纯度: >98.00%

    A potent inhibitor of γ-secretase

  • GC15917 structure
    GC15917CA-074 Me
    CAS: 147859-80-1
    纯度: >99.00% / >98.00%

    CA-074 Me（CA-074甲酯）是组织蛋白酶B（CB）的特异性抑制剂。

  • GC16317 structure
    GC16317CA 074
    CAS: 134448-10-5
    纯度: >99.50% / >98.00%

    CA 074是一种选择性组织蛋白酶B抑制剂，K i 值为2-5nM， CA 074对纯化的大鼠组织蛋白酶B的抑制作用比对组织蛋白酶H和L的抑制作用强10000-30000倍。

  • GC17303 structure
    GC17303Ritonavir
    CAS: 155213-67-5
    纯度: >99.50%

    An HIV protease inhibitor

  • GC10376 structure
    GC10376Cathepsin G Inhibitor I
    CAS: 429676-93-7
    纯度: >95.00%

    Cathepsin G Inhibitor I 是一种有效的、选择性的、可逆的、竞争性的、非肽的组织蛋白酶 G 抑制剂。

  • GC10930 structure
    GC10930Balapiravir
    CAS: 690270-29-2

    Balapiravir (Ro 4588161; R1626) 是 HCV (R1479; 4'-Azidocytidine) 的 RNA 依赖性 RNA 聚合酶 (RdRp) 的核苷类似物抑制剂的口服活性前药。

  • GC11640 structure
    GC11640MDL 28170
    CAS: 88191-84-8
    纯度: >97.00%

    MDL 28170是一种细胞渗透性、可逆的肽醛类抑制剂，可抑制钙蛋白酶（K i =0.01μM；对组织蛋白酶B的K i =0.025μM）。

  • GC11956 structure
    GC11956Raltegravir (MK-0518)
    CAS: 518048-05-0
    纯度: >98.00%

    Raltegravir (MK-0518) 是一种有效的整合酶 (IN) 抑制剂，用于治疗 HIV 感染。

  • GC14210 structure
    GC14210NSC 405020
    CAS: 7497-07-6
    纯度: >99.50%

    NSC 405020是一种特异性膜基质金属蛋白酶（MT1-MMP）小分子抑制剂。

  • GC14903 structure
    GC14903Cathepsin S inhibitor
    CAS: 1373215-15-6
    纯度: >98.00%

    A potent cathepsin S inhibitor

  • GC16752 structure
    GC16752Olmesartan medoxomil
    CAS: 144689-63-4
    纯度: >99.50%

    A prodrug form of olmesartan

  • GC17671 structure
    GC17671YO-01027 (Dibenzazepine, DBZ)
    CAS: 209984-56-5
    纯度: >98.00%

    YO-01027 (Dibenzazepine, DBZ)是一种γ-分泌酶抑制剂，对APP裂解和Notch裂解的IC 50 值分别为2.64±0.30nM和2.92±0.22nM。

  • GC12191 structure
    GC12191LY-411575
    CAS: 209984-57-6
    纯度: >98.00%

    A γ-secretase inhibitor

  • GC14074 structure
    GC14074Narlaprevir
    CAS: 865466-24-6
    纯度: >98.00%

    Narlaprevir是一种具有高效选择性和口服活性的丙型肝炎病毒的非结构蛋白3（HCV NS3）抑制剂，K i 值为6nM，EC 90 值为40nM。

  • GC16388 structure
    GC16388Odanacatib (MK-0822)
    CAS: 603139-19-1
    纯度: >98.00%

    Odanacatib (MK-0822)是一种具有口服活性的组织蛋白酶K（Cathepsin K）抑制剂。

  • GC16602 structure
    GC16602Darunavir
    CAS: 206361-99-1
    纯度: >99.50%

    An HIV-1 protease inhibitor

  • GC16894 structure
    GC16894Spinorphin
    CAS: 137201-62-8

    A peptide inhibitor of enkephalin-degrading enzymes

  • GC16912 structure
    GC16912PD 150606
    CAS: 179528-45-1
    纯度: >98.00%

    An inhibitor of calpains

  • GC17270 structure
    GC17270Simeprevir
    CAS: 923604-59-5
    纯度: >99.50%

    A potent NS3/4A protease inhibitor

  • GC17906 structure
    GC17906S/GSK1349572
    CAS: 1051375-16-6
    纯度: >98.00%

    A potent inhibitor of HIV integrase

  • GP10057 structure
    GP10057Amyloid β-Peptide (10-20) (human)
    CAS: 152286-31-2

    Amyloid β-Peptide (10-20) (human) 是 Amyloid-β 的片段；肽，可用于神经系统疾病的研究。

  • GC12407 structure
    GC12407Z-IETD-FMK
    CAS: 210344-98-2
    纯度: >98.00%

    Z-IETD-FMK（Z-IE(OMe)TD(OMe)-FMK）是一种选择性和细胞可渗透的 caspase-8抑制剂。

  • GC14152 structure
    GC14152Amprenavir (agenerase)
    CAS: 161814-49-9
    纯度: >98.00%

    A selective HIV protease inhibitor

  • GC16361 structure
    GC16361Geldanamycin
    CAS: 30562-34-6
    纯度: >99.50%

    Binds Hsp90 and GRP94, inhibits growth of cancer cells