Xanthine Oxidase
Xanthine Oxidase(黄嘌呤氧化酶)
Xanthine oxidase (XO) is an important enzyme catalyzing the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid which is excreted by kidneys. Xanthine oxidase belongs to the molybdenum-protein family containing one molybdenum, one of the flavin adenine dinucleotides (FAD), and two iron-sulfur (2Fe-2S) centers of the ferredoxin type in each of its two independent subunits. The enzyme contains two separated substrate-binding sites. XO catalysed the oxidation of hypoxanthine to xanthine and subsequently to uric acid.
Xanthine oxidase inhibitors (XOIs) are typically used in the treatment of nephropathy and renal stone diseases linked to hyperuricemia.
Xanthine Oxidase 相关产品(18)
- GC10827OxipurinolCAS: 2465-59-0纯度: >98.00%
An inhibitor of xanthine oxidase and active metabolite of allopurinol
- GC16319FebuxostatCAS: 144060-53-7纯度: >99.50%
An inhibitor of the oxidized and reduced forms of xanthine oxidase
- GC33813Xanthine oxidase-IN-1CAS: 1071970-13-2
Xanthine oxidase-IN-1 是一种黄嘌呤氧化酶抑制剂，提取自专利 WO2008126898A1，第 68 页，化合物实施例 3，IC50 为 6.5 nM。
- GC36903Phytic acid dodecasodium salt hydrateCAS: 123408-98-0纯度: >98.00%
Phytic acid dodecasodium salt hydrate 是一种天然存在于豆科植物种子中的抗营养素。
- GC39050PrudomestinCAS: 3443-28-5
Prudomestin，从 Prunus domestica 心材中分离得到，具有很强的黄嘌呤氧化酶 (XO) 抑制活性(IC50≈6?µM)。
- GC52049Myricetin 3-galactosideCAS: 15648-86-9纯度: >98.00%
A flavonoid with diverse biological activities
- GC64122TigulixostatCAS: 1287766-55-5
Tigulixostat (LC350189) 是一种具有口服活性的非嘌呤选择性黄嘌呤氧化酶 (xanthine oxidase) 抑制剂。Tigulixostat 降低尿酸的产生，可用于痛风和高尿酸血症研究。
- GC720637,8,3′,4′-TetrahydroxyflavoneCAS: 3440-24-2纯度: >99.00%
7,8,3′,4′-Tetrahydroxyflavone（化合物2）是一种强效的黄嘌呤氧化酶（XOD）抑制剂，IC50值为10.488µM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC10827 | Oxipurinol | 2465-59-0 | >98.00% | |
An inhibitor of xanthine oxidase and active metabolite of allopurinol | ||||
| GC14930 | Benzbromarone | 3562-84-3 | >99.50% | |
An inhibitor of URAT1 | ||||
| GC15322 | Allopurinol | 315-30-0 | >99.50% / >98.00% | |
Inhibitor of xanthine oxidase | ||||
| GC16127 | Topiroxostat | 577778-58-6 | >98.00% | |
An inhibitor of xanthine oxidoreductase | ||||
| GC16319 | Febuxostat | 144060-53-7 | >99.50% | |
An inhibitor of the oxidized and reduced forms of xanthine oxidase | ||||
| GC33813 | Xanthine oxidase-IN-1 | 1071970-13-2 | - | |
Xanthine oxidase-IN-1 是一种黄嘌呤氧化酶抑制剂，提取自专利 WO2008126898A1，第 68 页，化合物实施例 3，IC50 为 6.5 nM。 | ||||
| GC36036 | Febuxostat D9 | 1246819-50-0 | - | |
An internal standard for the quantification of febuxostat | ||||
| GC36903 | Phytic acid dodecasodium salt hydrate | 123408-98-0 | >98.00% | |
Phytic acid dodecasodium salt hydrate 是一种天然存在于豆科植物种子中的抗营养素。 | ||||
| GC38116 | Purpurogallin | 569-77-7 | >96.00% / >98.00% | |
A phenol | ||||
| GC39050 | Prudomestin | 3443-28-5 | - | |
Prudomestin，从 Prunus domestica 心材中分离得到，具有很强的黄嘌呤氧化酶 (XO) 抑制活性(IC50≈6?µM)。 | ||||
| GC41531 | Anacardic Acid Triene | 103904-73-0 | >98.00% | |
A polyunsaturated form of anacardic acid | ||||
| GC42578 | 6-Formylpterin | 712-30-1 | >98.00% | |
An intracellular generator of hydrogen peroxide | ||||
| GC52049 | Myricetin 3-galactoside | 15648-86-9 | >98.00% | |
A flavonoid with diverse biological activities | ||||
| GC64122 | Tigulixostat | 1287766-55-5 | - | |
Tigulixostat (LC350189) 是一种具有口服活性的非嘌呤选择性黄嘌呤氧化酶 (xanthine oxidase) 抑制剂。Tigulixostat 降低尿酸的产生，可用于痛风和高尿酸血症研究。 | ||||
| GC72063 | 7,8,3′,4′-Tetrahydroxyflavone | 3440-24-2 | >99.00% | |
7,8,3′,4′-Tetrahydroxyflavone（化合物2）是一种强效的黄嘌呤氧化酶（XOD）抑制剂，IC50值为10.488µM。 | ||||
| GC72074 | Broussoflavonol F | 162558-94-3 | >98.00% | |
Broussoflavonol F具有黄嘌呤氧化酶抑制活性。 | ||||
| GN10158 | Baicalein | 491-67-8 | >98.50% / >98.00% | |
Baicalein（黄芩素；5，6，7-三羟基黄酮）是具有多种生物活性的黄酮类化合物，是黄嘌呤氧化酶抑制剂，IC 50 值为3.12μM。 | ||||
| GN10554 | Phytic acid | 83-86-3 | - | |
Phytic acid 是一种天然存在于豆科植物种子中的抗营养素。 | ||||