Phytic acid is an antinutrient found naturally in legume seeds [1]. Phytic acid and its degradation products can scavenge free radicals and reduce oxidative stress [2]. Phytic acid chelation of metal ions (such as iron) can reduce metal-catalyzed oxidative reactions [3]. Phytic acid exhibits anticancer and antioxidant properties [4].
In MC65 cells, Cell survival rate was significantly improved after Phytic acid (100μM; 4d) treatment [5]. In HepG2 cells, Phytic acid (0.1-4mM; 24-48h) treatment inhibited cell growth [6].
In dextran sulfate sodium (DSS)-induced UC mice model, Phytic acid (0.25g/kg; ig; 14d) treatment improved weight loss, shortened colon length, improved clinical scores, and reduced the release of proinflammatory factors (Il-1β, Il-6, and TNF-α) [7]. In a high-fat diet mice model, Phytic acid (0.25-2mg/mL; po; 13 weeks) significantly inhibited obesity and alleviated hepatic steatosis [8].
References:
[1]. Oatway L, Vasanthan T, Helm J H. Phytic acid[J]. Food Reviews International, 2001, 17(4): 419-431.
[2]. Graf E, Empson K L, Eaton J W. Phytic acid. A natural antioxidant[J]. Journal of Biological Chemistry, 1987, 262(24): 11647-11650.
[3]. Lee B J, Hendricks D G. Metal‐catalyzed oxidation of ascorbate, deoxyribose and linoleic acid as affected by phytic acid in a model system[J]. Journal of Food Science, 1997, 62(5): 935-984.
[4]. Bloot A P M, Kalschne D L, Amaral J A S, et al. A review of phytic acid sources, obtention, and applications[J]. Food Reviews International, 2023, 39(1): 73-92.
[5]. Anekonda T S, Wadsworth T L, Sabin R, et al. Phytic acid as a potential treatment for Alzheimer's pathology: evidence from animal and in vitro models[J]. Journal of Alzheimer’s disease, 2011, 23(1): 21-35.
[6]. Al-Fatlawi A A, Al-Fatlawi A A, Irshad M, et al. Rice bran phytic acid induced apoptosis through regulation of Bcl-2/Bax and p53 genes in HepG2 human hepatocellular carcinoma cells[J]. Asian Pacific Journal of Cancer Prevention, 2014, 15(8): 3731-3736.
[7]. Hou X, Sang Y, Dong L. The improved effect and its mechanism of phytic acid on DSS-induced UC mice[J]. Life sciences, 2022, 311: 121139.
[8]. Ran X, Hu G, He F, et al. Phytic acid improves hepatic steatosis, inflammation, and oxidative stress in high-fat diet (HFD)-fed mice by modulating the gut–liver axis[J]. Journal of Agricultural and Food Chemistry, 2022, 70(36): 11401-11411.
Phytic acid 是一种天然存在于豆科植物种子中的抗营养素 [1]。Phytic acid及其降解产物可以清除自由基，降低氧化应激 [2]。Phytic acid与金属离子（如铁）的螯合可以降低金属催化的氧化反应 [3]。Phytic acid具有抗癌和抗氧化作用 [4]。
在MC65细胞中，Phytic acid（100μM；4d）处理后细胞存活率显著提高 [5]。在HepG2细胞中，Phytic acid（0.1-4mM；24-48h）处理可抑制细胞生长 [6]。
在葡聚糖硫酸钠（DSS）诱导的溃疡性结肠炎（UC）小鼠模型中，Phytic acid（0.25g/kg；ig；14d）治疗可改善体重减轻、缩短结肠长度、改善临床评分，并减少促炎因子（IL-1β、IL-6和TNF-α）的释放 [7]。在高脂饮食小鼠模型中，Phytic acid（0.25-2mg/mL；po；13周）显著抑制肥胖并减轻肝脏脂肪变性 [8]。