GlpBio

Neprilysin

Neprilysin(脑啡肽酶)

Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.

Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.

Neprilysin 相关产品(12)

  • GC10146 structure
    GC10146AHU-377(Sacubitril)
    CAS: 149709-62-6
    纯度: >99.00%

    A prodrug form of LBQ657

  • GC11784 structure
    GC11784LCZ696
    CAS: 936623-90-4
    纯度: >99.50%

    A dual angiotensin II receptor antagonist and neprilysin inhibitor

  • GC16138 structure
    GC16138AHU-377 hemicalcium salt
    CAS: 1369773-39-6
    纯度: >99.50%

    A prodrug form of LBQ657

  • GC16768 structure
    GC16768Phosphoramidon Disodium Salt
    CAS: 164204-38-0

    An inhibitor of NEP and NEP2

  • GC17017 structure
    GC17017Racecadotril
    CAS: 81110-73-8
    纯度: >98.50%

    An enkephalinase inhibitor

  • GC30786 structure
    GC30786Sacubitrilat (LBQ-657)
    CAS: 149709-44-4
    纯度: >98.00%

    A neprilysin inhibitor

  • GC31267 structure
    GC31267NEP-In-1
    CAS: 465527-94-0

    NEP-IN-1是一种中性肽链内切酶(NEP)抑制剂，抑制dNEP,IC50为2nM。

  • GC31583 structure
    GC31583SQ28603 (SQ28,603)
    CAS: 100845-83-8

    SQ28603 (SQ28,603) 是中性肽链内切酶 3.4.24.11 (NEP) 的有效选择性抑制剂，NEP 是一种降解心房利钠肽 (ANP) 的酶。

  • GC31608 structure
    GC31608Candoxatril (UK 79300)
    CAS: 123122-55-4

    Candoxatril (UK 79300) 是一种中性肽链内切酶 (NEP) 抑制剂。

  • GC32671 structure
    GC32671NEP-IN-2
    CAS: 145775-14-0

    NEP-IN-2是一种neutralendopeptidase抑制剂，主要用于研究动脉粥样硬化、再狭窄症的扩散等症状。

  • GC38856 structure
    GC38856TD-0212 TFA
    CAS: 1073549-11-7
    纯度: >98.00%

    TD-0212 TFA 是一种具有口服活性的、血管紧张素II型1受体AT1 和脑啡肽酶 (NEP)的双抑制剂，其对AT1的pKi值为 8.9， 对NEP 的pIC50值为9.2。

  • GC63732 structure
    GC63732Sacubitril-13C4 hemicalcium salt

    Sacubitril-13C4 (AHU-377-13C4) hemicalcium salt 是 13C 和氘代标记的 Sacubitril hemicalcium salt。Sacubitril (AHU-377) hemicalcium salt 是有效的NEP抑制剂，IC50值为5 nM。Sacubitril hemicalcium salt 是研究心力衰竭药物 LCZ696 的一个组分。