GlpBio

Sacubitrilat (LBQ-657)

目录号: GC30786纯度: >98.00%同义词: LCZ696杂质,Desethyl Sacubitril; LBQ-657
A neprilysin inhibitor
Sacubitrilat (LBQ-657)
Cas No.: 149709-44-4
规格价格库存数量操作
2mg¥674.00现货
1
5mg¥1,080.00现货
1
10mg¥1,800.00现货
1
25mg¥3,960.00现货
1
50mg¥6,300.00现货
1
10mM (in 1mL DMSO)¥1,188.00现货
1
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文献被引

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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

LBQ657 is an inhibitor of neprilysin (IC50 = 5 nM).1 It is selective for neprilysin over angiotensin converting enzyme (ACE) when used at a concentration of 10 μM. LBQ657 inhibits neprilysin cleavage of enkephalin, glutaryl-Ala-Ala-Phe-β-napthylamide, and atrial natriuretic factor (IC50s = 5, 0.74, and 5.3 nM, respectively).

1.Ksander, G.M., Ghai, R.D., deJesus, R., et al.Dicarboxylic acid dipeptide neutral endopeptidase inhibitorsJ. Med. Chem.38(10)1689-1700(1995)

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
149709-44-4
同义词
LCZ696杂质,Desethyl Sacubitril; LBQ-657
SMILES
[H]N(C(CCC(O)=O)=O)[C@H](CC(C=C1)=CC=C1C2=CC=CC=C2)C[C@H](C(O)=O)C
分子式
C22H25NO5
分子量
383.44 g/mol
溶解性
DMSO : ≥ 100 mg/mL (260.80 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol