Adenylosuccinic acid is a purine nucleotide and an intermediate in the purine nucleotide cycle.[1] It is converted into AMP and fumarate by adenylosuccinate lyase in the cytosol. Adenylosuccinic acid (10 µM) inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay.[2] Adenylosuccinic acid (10 µM) increases glucose-induced insulin exocytosis in 832/13 INS-1 pancreatic β-cells.[3] It induces contractions in isolated guinea pig uterus strips when used at a concentration of 100 µM.[4]
腺苷琥珀酸是一种嘌呤核苷酸，也是嘌呤核苷酸循环中的中间产物。它在胞质中被腺苷琥珀酸裂解酶转化为AMP和富马酸。腺苷琥珀酸（10微米）通过贴片钳技术抑制离体大鼠棕色脂肪细胞中的非选择性阳离子通道的钙离子诱导活化。[2] 腺苷琥珀酸（10微米）增加了832/13 INS-1胰岛素分泌细胞中葡萄糖诱导的胰岛素外分泌。[3] 使用100 µM的浓度时，它会在离体豚鼠子宫带中引起收缩。[4]
Reference:
[1]. Waarde, A. Operation of the purine nucleotide cycle in animal tissues. Biol. Rev. Camb. Philos. Soc. 63(2), 259-298 (1988).
[2]. Halonen, J., and Nedergaard, J. Adenosine 5'-monophosphate is a selective inhibitor of the brown adipocyte nonselective cation channel. J. Membr. Biol. 188(1), 183-197 (2002).
[3]. Gooding, J.R., Jensen, M.W., Dai, X., et al. Adenylosuccinate is an insulin secretagogue derived from glucose-induced purine metabolism. Cell Rep. 13(1), 157-167 (2015).
[4]. Nishida, Y., and Miyamoto, T. Contractile effect of succinylpurines on guinea pig uterus. Gen. Pharmacol. 19(2), 277-279 (1988).