GlpBio

Isocitrate Dehydrogenase (IDH)

Isocitrate Dehydrogenase (IDH)(异柠檬酸脱氢酶)

Isocitrate dehydrogenase (IDH) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producingalpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate(a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as themitochondrion and peroxisome.

Isocitrate Dehydrogenase (IDH) 相关产品(28)

  • GC10485 structure
    GC10485Mutant IDH1-IN-1
    CAS: 1355326-21-4
    纯度: >99.50%

    An inhibitor of mutant IDH1

  • GC10531 structure
    GC10531AGI-5198
    CAS: 1355326-35-0
    纯度: >98.00%

    A potent, selective inhibitor of IDH1 mutations

  • GC13147 structure
    GC13147AG-221 (Enasidenib)
    CAS: 1446502-11-9
    纯度: >99.50%

    An inhibitor of mutant IDH2

  • GC14757 structure
    GC14757AGI-6780
    CAS: 1432660-47-3
    纯度: >98.00%

    A potent, selective inhibitor of mutant IDH2

  • GC15601 structure
    GC15601AG-120
    CAS: 1448347-49-6
    纯度: >99.50% / >98.00%

    AG-120 (Ivosidenib)是一种突变型异柠檬酸脱氢酶1（mIDH1）抑制剂。

  • GC17809 structure
    GC17809GSK864
    CAS: 1816331-66-4
    纯度: >99.00% / >98.00%

    GSK864是一种突变型isocitrate dehydrogenases 1 (mIDH1)抑制剂，对IDH1 R132H、IDH1 R132C及WT IDH1的EC 50 值分别为0.16μM、0.10μM和2.74μM。

  • GC18423 structure
    GC18423IDH305
    CAS: 1628805-46-8
    纯度: >98.00%

    A potent and selective inhibitor of mutant IDH1

  • GC19059 structure
    GC19059BAY-1436032
    CAS: 1803274-65-8
    纯度: >99.00%

    An inhibitor of mutant IDH1

  • GC19380 structure
    GC19380Vorasidenib
    CAS: 1644545-52-7
    纯度: >99.50%

    An inhibitor of mutant IDH1 and IDH2

  • GC31874 structure
    GC31874Olutasidenib (FT-2102)
    CAS: 1887014-12-1
    纯度: >99.00%

    An inhibitor of mutant IDH1

  • GC32904 structure
    GC32904Enasidenib mesylate (AG-221 mesylate)
    CAS: 1650550-25-6
    纯度: >99.50%

    An inhibitor of mutant IDH2

  • GC32966 structure
    GC32966Mutant IDH1-IN-2
    CAS: 1429176-69-1
    纯度: >98.50%

    MutantIDH1-IN-2是一种突变型异柠檬酸脱氢酶(IDH)蛋白抑制剂,在LS-MS生物化学检测中IC50值为<22nM,荧光生物化学检测中IC50值为16.6nM。

  • GC33318 structure
    GC33318Mutant IDH1-IN-4
    CAS: 1416270-18-2
    纯度: >99.00%

    MutantIDH1-IN-4(compound434)是一种突变型异柠檬酸脱氢酶1(IDH1)的抑制剂，其对R132H、HT1080和U87R132H细胞中的突变型IDH1的IC50值≤0.5μM。

  • GC34417 structure
    GC34417(R,S)-Ivosidenib ((R,S)-AG-120)

    (R,S)-Ivosidenib是一种异柠檬酸脱氢酶(IDH1)抑制剂。

  • GC36292 structure
    GC36292IDH1 Inhibitor 2
    CAS: 2244895-42-7

    IDH1 Inhibitor 2 是有效的IDH1 抑制剂，通过对 His315的共价修饰发挥作用，其IC50 值为110 nM。

  • GC36293 structure
    GC36293IDH1 Inhibitor 3
    CAS: 2171081-24-4

    IDH1 Inhibitor 3 (compound 6f) 是突变型的 IDH1 的抑制剂，其对IDH1R132H 的 IC50 值为 45 nM。

  • GC36665 structure
    GC36665Mutant IDH1 inhibitor
    CAS: 1429180-08-4
    纯度: >98.50%

    Mutant IDH1 inhibitor 是一个有效的突变型 IDH1 R132H 的抑制剂，IC50 值小于 72 nM。

  • GC38640 structure
    GC38640IDH889
    CAS: 1429179-07-6
    纯度: >98.50%

    IDH889 是一种可口服利用的，脑渗透性的，变构和突变特异性的异柠檬酸脱氢酶 (IDH1) 抑制剂。IDH889 对 IDH1 R132* 突变型具有高效选择性，对 IDH1R132H、IDH1R132C 和 IDH1wt 作用的 IC50 值分别为 0.02 μM, 0.072 μM 和 1.38 μM。IDH889 具有高效的细胞内 2-HG 水平抑制作用，其 IC50 值为 0.014 μM。

  • GC39157 structure
    GC39157DS-1001b
    CAS: 1898207-64-1
    纯度: >98.50%

    An inhibitor of mutant IDH1

  • GC50129 structure
    GC50129TC-E 5008
    CAS: 50405-58-8

    Selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor; phenotypically lethal

  • GC64359 structure
    GC64359(R,R)-GSK321
    CAS: 1816272-19-1
    纯度: >99.00%

    (R,R)-GSK321是一种突变型R132H IDH1抑制剂，IC 50 值为120nM。

  • GC65554 structure
    GC65554IDH1 Inhibitor 1
    CAS: 2234285-81-3
    纯度: >99.00%

    IDH1 Inhibitor 1 是一种有效的，口服生物可利用的，脑渗透性，选择性突变 IDH1 抑制剂，抑制 IDH1R132H，IDH1R132C，和 IDH1WT，IC50 分别为 0.021 μM, 0.045 μM, 和 2.52 μM。具有抗肿瘤活性。

  • GC65883 structure
    GC65883(S,R)-WT IDH1 Inhibitor 2
    CAS: 1816272-18-0
    纯度: >98.00%

    (S,R)-WT IDH1 Inhibitor 2 (GSK321) 是一个有效的选择性突变型 IDH1 抑制剂，抑制 R132G、R132C、R132H 和 WT IDH1 的 IC50 值分别为 2.9、3.8、4.6 和 46 nM，选择性比 IDH2 高出 100 倍。(S,R)-WT IDH1 Inhibitor 2 诱导细胞内 2-HG 减少，髓细胞分化阻滞失效，在白血病母细胞和更不成熟的干细胞水平诱导粒细胞分化。(S,R)-WT IDH1 Inhibitor 2 可用于急性髓系白血病 (AML) 及其他癌症的研究。

  • GC67682 structure
    GC67682(S,S)-GSK321
    CAS: 1816272-20-4

    (S,S)-GSK321 是 GSK321 的 (S,S)-对映异构体。