GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GN10783 structure
    GN10783(R) Ginsenoside Rh2
    CAS: 112246-15-8
    纯度: >98.00%

    A steroid glycoside with diverse biological activities

  • GN10792 structure
    GN10792Caffeic acid
    CAS: 331-39-5
    纯度: >98.50%

    An inhibitor of 5-LO

  • GN10801 structure
    GN10801Senkyunolide I
    CAS: 94596-28-8
    纯度: >99.50%

    Senkyunolide I 是从川芎中分离出来的，是一种抗偏头痛化合物。

  • GN10810 structure
    GN10810Cordycepin
    CAS: 73-03-0
    纯度: >99.00% / >97.50% / >98.00%

    Cordycepin（3’-deoxyadenosine; 虫草素）是一种核苷类似物，抑制聚腺苷酸化。

  • GP10077 structure
    GP10077Angiotensin (1-7)
    CAS: 51833-78-4

    Angiotensin (1-7)是一种存在于心脏和肾脏的七肽，在血浆和心房组织中抑制血管紧张素转换酶(ACE)的IC 50 值分别为3.0和4.0μM。

  • GP24734 structure
    GP24734Streptolysin-O

    链球菌溶血素-O 化脓性链球菌重组体

  • GP24824 structure
    GP24824Thrombin

    人类凝血酶

  • GP26142 structure
    GP26142CTSF Human, Sf9

    CTSF produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 474 amino acids (20-484

  • GP26143 structure
    GP26143CTSZ Mouse, Active

    CTSZ Mouse Recombinant produced in Baculovirus is a single, glycosylated, polypeptide chain containing 292 amino acids (23-306 aa) and having a molecular mass of32

  • GP26167 structure
    GP26167MMP2 Mouse

    MMP2 Mouse produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 644 amino acids (30-662 aa) and having a molecular mass of 72

  • GP26168 structure
    GP26168MMP9 Mouse

    MMP9 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 711 amino acids (20-730 a

  • GP26352 structure
    GP26352THBD Human

    THBD Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 500 amino acids (22-515a

  • GC10240 structure
    GC10240Atazanavir sulfate (BMS-232632-05)
    CAS: 229975-97-7
    纯度: >99.50%

    An inhibitor of HIV-1 protease

  • GC10832 structure
    GC10832VX-222 (VCH-222, Lomibuvir)
    CAS: 1026785-59-0

    An HCV polymerase inhibitor

  • GC11218 structure
    GC11218Z-VDVAD-FMK
    CAS: 210344-92-6
    纯度: >98.00%

    Z-VDVAD-FMK是一种不可逆的、具有细胞渗透性的caspase-2特异性抑制剂。

  • GC12152 structure
    GC12152Acetyl-Calpastatin (184-210) (human)
    CAS: 123714-50-1

    Acetyl-Calpastatin (184-210) (human) 是一种有效、选择性和可逆的钙蛋白酶抑制剂，对 µ-calpain 和组织蛋白酶 L 的 Ki 值分别为 0.2 nM 和 6 μM。

  • GC12299 structure
    GC12299Telaprevir (VX-950)
    CAS: 402957-28-2
    纯度: >98.00%

    An HCV NS3/4A protease inhibitor

  • GC12725 structure
    GC12725VX-765
    CAS: 273404-37-8
    纯度: >99.50% / >98.00%

    VX-765 是一种新开发的选择性小分子 caspase-1 抑制剂，可通过血脑屏障并在体外和体内减少炎症。

  • GC12879 structure
    GC12879Danoprevir (RG7227)
    CAS: 850876-88-9
    纯度: >99.50%

    An HCV NS3/4A protease inhibitor

  • GC13413 structure
    GC13413Z-VEID-FMK
    CAS: 210344-96-0

    Caspase-6抑制剂

  • GC13787 structure
    GC13787E 64d
    CAS: 88321-09-9
    纯度: >99.50%

    E 64d是一种可渗透细胞的不可逆的广谱半胱氨酸蛋白酶抑制剂，具有抑制血小板聚集的活性。

  • GC14466 structure
    GC14466Fluorouracil (Adrucil)
    CAS: 51-21-8
    纯度: >98.00%

    氟尿嘧啶 (Adrucil) (5-FU) 是尿嘧啶的类似物，在 C-5 位置用氟原子代替氢 。

  • GC17920 structure
    GC17920Vicriviroc Malate
    CAS: 541503-81-5

    CCR5 antagonist, orally active, second generation

  • GC15295 structure
    GC15295AUY922 (NVP-AUY922)
    CAS: 747412-49-3
    纯度: >99.50% / >98.00%

    AUY922 (NVP-AUY922)是一种高效且选择性的 HSP90抑制剂，对 HSP90α和 HSP90β的 IC 50 值分别为 13nM和 21nM。