GlpBio

Serine Protease

Serine Protease(丝氨酸蛋白酶)

Serine proteases, named for the nucleophilic Ser residue at the active site, are a large and diverse group of proteases (accounting for approximately one-third of all proteases) that are characterized by the presence of the Asp-His-Ser “charge relay” system (catalytic triad) in their chemical structures. However, with the development of technology, a variety of novel serine proteases with catalytic triads and dyads have been discovered, including Ser-His-Glu, Ser-Lys/His, His-Ser-His and N-terminal Ser. Serine proteases are traditionally divided into four clans based on the Asp-His-Ser triad in different structural contexts, including chymotrypsin-like proteases, subtilisin-like proteases, carboxypeptidase Y-like proteases and Clp protease-like proteases.

Serine Protease 相关产品(15)

  • GC12900 structure
    GC12900Aprotinin
    CAS: 9087-70-1
    纯度: Po-6115U/mg (dried product) / Po-6000U/mg (dried product)

    抑肽酶是一种天然存在的丝氨酸蛋白酶抑制剂，可挽救生命并降低中风和因大量出血而重复手术的风险1, 2, 3。

  • GC10027 structure
    GC10027Leupeptin, Microbial
    CAS: 103476-89-7
    纯度: >98.00%

    Leupeptin, Microbial 是一种广谱丝氨酸和半胱氨酸蛋白酶抑制剂。

  • GC10613 structure
    GC10613Nafamostat Mesylate(FUT-175)
    CAS: 82956-11-4
    纯度: >98.00%

    Nafamostat Mesylate(FUT-175)是一种合成的丝氨酸蛋白酶抑制剂。

  • GC13421 structure
    GC13421UCF 101
    CAS: 313649-08-0
    纯度: >98.00%

    An Omi/HtrA2 protease inhibitor

  • GC13967 structure
    GC13967Tosyllysine Chloromethyl Ketone (hydrochloride)
    CAS: 4272-74-6
    纯度: >98.00%

    A non-selective proteinase inhibitor

  • GC14502 structure
    GC14502AEBSF.HCl
    CAS: 30827-99-7
    纯度: >99.50% / >98.50% / >98.00% / >99.00%

    AEBSF.HCl是丝氨酸蛋白酶广谱的不可逆的抑制剂，可抑制胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶，胰蛋白酶和相关的溶栓酶等。

  • GC15682 structure
    GC15682Chymostatin
    CAS: 9076-44-2
    纯度: >95.00%

    Chymostatin是一种选择性强的蛋白酶体糜蛋白酶样活性抑制剂，Chymostatin对胰凝乳蛋白酶和凝乳酶的Ki分别为9.36nM和13.1nM。

  • GC17711 structure
    GC17711PPACKII (trifluoroacetate salt)
    CAS: 649748-23-2

    An irreversible inhibitor of kallikreins

  • GC26017 structure
    GC26017UK-371804 HCl
    CAS: 256476-36-5

    UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).

  • GC39256 structure
    GC39256LP-935509
    CAS: 1454555-29-3
    纯度: >99.50%

    LP-935509 是一种小分子衔接蛋白-2 相关激酶1 (AAK1) 选择性和脑渗透抑制剂 (IC50=3.3 nM)，一种 ATP 竞争性抑制剂，其 Ki 为 0.9 nM。 LP-935509 是 BIKE 的有效抑制剂 (IC50=14 nM) 和适度的 GAK 抑制剂 (IC50=320 nM)。 LP-935509 可逆转 SNL 手术后的疼痛。

  • GC49221 structure
    GC49221QLT0267
    CAS: 866409-68-9
    纯度: >98.00%

    An ILK inhibitor

  • GC69422 structure
    GC69422M4K2234
    CAS: 2421141-51-5
    纯度: >98.00%

    M4K2234 (compound 26b) 是 ALK2 的抑制剂。M4K2234 抑制 ALK2 和 ALK5 的 IC50 值分别为 5 和 2144 nM。M4K2234 可用作 ALK1 和 ALK2 蛋白激酶的化学探针。M4K2234 可用于癌症的研究。

  • GC90893 structure
    GC90893Rp-Adenosine-5'-O-(1-thiodiphosphate) (sodium salt)
    CAS: 2005478-89-5
    纯度: >95.00%

    ADP-α-S的同分异构体

  • GC90894 structure
    GC90894Sp-Adenosine-5'-O-(1-thiodiphosphate) (sodium salt)
    CAS: 2005478-90-8
    纯度: >95.00%

    ADP-α-S的同分异构体

  • GC10477 structure
    GC10477PMSF
    CAS: 329-98-6
    纯度: >98.00% / >99.00%

    PMSF (苯甲基磺酰氟)是一种不可逆的丝氨酸蛋白酶抑制剂，常在细胞或组织裂解之前加入裂解液中以预防蛋白的降解。