UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
In Vitro, UK-3718046 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 µM)[1].
In Vivo, in a porcine acute excisional wound model, following topical delivery, UK-3718046 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters[1].
[1] Fish PV, et al. J Med Chem. 2007, 50(10):2341-51.