GlpBio

DPP-4

DPP-4(二肽基肽酶4)

Dipeptidyl peptidase-4 (DPP-4), originally identified in 1966 as a dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide, is a membrane-associated peptidase that selectively cleaves the N-terminal penultimate proline or alanine amino acids. The most common substrates of DPP-4 include glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), peptide YY, neuropeptide, chemokine ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) and substance P. DPP-4, as a type II cell surface protein and a soluble form, has been found to be widely distributed in organs (such as the bone marrow, the lung, spleen, liver, pancreas, kidney and intestines) and body fluids (such as serum/plasma, cerebrospinal fluid, synovial fluid and semen). Besides its peptidase activity, DPP-4 has been found to be associated with immune stimulation, extracellular matrix degradation, lipid accumulation and resistance to anticancer agents.

DPP-4 相关产品(18)

  • GC10104 structure
    GC10104Glimepiride
    CAS: 93479-97-1
    纯度: >99.50% / >98.00%

    Glimepiride为第二代磺酰脲类药物，可刺激胰岛β细胞释放胰岛素，作为单药或与二甲双胍、胰岛素联合用于治疗2型糖尿病。

  • GC12895 structure
    GC12895Saxagliptin
    CAS: 361442-04-8
    纯度: >99.50%

    Saxagliptin是一种高效二肽基肽酶-4（DPP-4）抑制剂，通过选择性抑制DPP-4酶，从而升高内源性胰高血糖素样肽-1（GLP-1）和葡萄糖依赖性促胰岛素释放多肽（GIP）的水平以调节血糖。

  • GC12235 structure
    GC12235Sitagliptin (phosphate)
    CAS: 654671-78-0
    纯度: >98.00%

    A DPP-4 inhibitor

  • GC14786 structure
    GC14786P32/98 (hemifumarate)
    CAS: 251572-86-8

    A DPP IV inhibitor

  • GC17012 structure
    GC17012MK3102
    CAS: 1226781-44-7
    纯度: >99.00%

    MK3102 (Omarigliptin)是一种新型的每周一次的二肽基肽酶-4 (DPP-4)抑制剂(IC50: 2.2 nM)，用于治疗2型糖尿病。

  • GC10298 structure
    GC10298Sitagliptin phosphate monohydrate
    CAS: 654671-77-9
    纯度: >99.50%

    Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) 是一种有效的 DPP4 抑制剂，在 Caco-2 细胞提取物中的 IC50 为 19 nM。

  • GC13949 structure
    GC13949Alogliptin Benzoate
    CAS: 850649-62-6
    纯度: >99.50%

    A DPP-4 inhibitor

  • GC17479 structure
    GC17479Trelagliptin succinate
    CAS: 1029877-94-8
    纯度: >99.50%

    A DDP-4 inhibitor

  • GC15130 structure
    GC15130Alogliptin (SYR-322)
    CAS: 850649-61-5
    纯度: >98.00% / >99.00%

    Alogliptin (SYR-322) (SYR-322 free base) 是一种有效的、选择性的、具有口服活性的 DPP-4 抑制剂，IC50 <10 nM，选择性比 DPP-8 和 DPP-9 高 10,000 倍以上.

  • GC16613 structure
    GC16613Trelagliptin
    CAS: 865759-25-7
    纯度: >99.50%

    A DDP-4 inhibitor

  • GC15576 structure
    GC15576Teneligliptin hydrobromide
    CAS: 906093-29-6
    纯度: >99.50%

    A DPP-4 inhibitor

  • GC12603 structure
    GC12603DPPI 1c hydrochloride
    CAS: 866396-34-1

    A DPP-4 inhibitor

  • GC14126 structure
    GC14126NVP DPP 728 dihydrochloride
    CAS: 247016-69-9

    NVP DPP 728 dihydrochloride 是一种有效的、可逆的和腈依赖性二肽基肽酶 IV (DPP-IV) 抑制剂。

  • GC10802 structure
    GC10802K 579
    CAS: 440100-64-1

    K 579 是一种有效且具有口服活性的二肽基肽酶 IV 抑制剂。

  • GC14201 structure
    GC14201PK 44 phosphate
    CAS: 1017682-65-3

    DPP-IV inhibitor

  • GC16733 structure
    GC16733Vildagliptin (LAF-237)
    CAS: 274901-16-5
    纯度: >98.00%

    A DPP-4 inhibitor

  • GC14827 structure
    GC14827Linagliptin (BI-1356)
    CAS: 668270-12-0
    纯度: >99.50%

    A potent DPP-4 inhibitor

  • GC10018 structure
    GC10018Talabostat mesylate
    CAS: 150080-09-4
    纯度: >99.00%

    Talabostat (PT100)是一种口服活性和非选择性二肽基肽酶IV（DPP-IV）抑制剂(IC50 < 4 nM; Ki = 0.18 nM)和成纤维细胞活化蛋白(FAP)的第一种临床抑制剂(IC50 = 560 nM)，抑制DPP 8/9(IC50= 4/11 nM; Ki = 1.5/0.76 nM)，静止细胞脯氨酸二肽酶(QPP)( IC50= 310 nM)，DPP 2和其他一些DASH家族酶。