GlpBio

Lactate Dehydrogenase

Lactate Dehydrogenase(乳酸脱氢酶)

Lactate Dehydrogenase (LDH), which catalyzes the inter-conversion of pyruvate and lactate.

Mammalian lactate dehydrogenase (LDH) comprises three major families of conserved enzymes that catalyse the reversible interconversion of pyruvate and lactate, a key metabolic step in glycolysis and other metabolic pathways. At least five LDH tetrameric isozymes are reported in somatic mammalian tissues, comprising LDHA and LDHB subunits, whereas LDHC4 is found only in mature testis and spermatozoa, where it is required for male fertility. Lactate dehydrogenase catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. At high concentrations of lactate, the enzyme exhibits feedback inhibition, and the rate of conversion of pyruvate to lactate is decreased. Dihydroorotate dehydrogenase (DHODH) is a key enzyme that catalyzes the oxidation of dihydroorotate (DHO) to produce orotate, a key step in pyrimidine biosynthesis.

Lactate Dehydrogenase 相关产品(19)

  • GC13464 structure
    GC13464GSK 2837808A
    CAS: 1445879-21-9
    纯度: >99.00%

    GSK2837808A 是一种选择性的 LDHA (lactate dehydrogenase A) 的抑制剂,对hLDHA和hLDHB的IC50分别为2.6 nM和43 nM.GSK2837808A(10 µM;24-72h)通过促进有氧糖酵解、增殖、细胞周期和细胞凋亡抵抗,阻断了着丝粒蛋白N (CENP-N)过表达对鼻咽癌细胞的影响。

  • GC14851 structure
    GC14851Vidofludimus
    CAS: 717824-30-1
    纯度: >98.50%

    An immunosuppressive drug that inhibits DHODH

  • GC18183 structure
    GC18183Nifurtimox
    CAS: 23256-30-6
    纯度: >99.50% / >98.00%

    An antiprotozoal agent

  • GC19012 structure
    GC19012(R)-GNE-140
    CAS: 2003234-63-5
    纯度: >99.00%

    (R)-GNE-140是一种具有口服活性的乳酸脱氢酶A（LDHA）抑制剂，(R)-GNE-140对LDHA（IC 50 =3nM）和LDHB（IC 50 =5nM）的抑制活性均比S型异构体的高。

  • GC32694 structure
    GC32694GNE-140 racemate
    CAS: 1802977-61-2
    纯度: >98.00%

    GNE-140racemate是(R)-GNE-140和(S)-GNE-140的外消旋混合物。(R)-GNE-140是有效的乳酸脱氢酶A(LDHA)抑制剂。

  • GC32838 structure
    GC32838BAY-2402234
    CAS: 2225819-06-5
    纯度: >99.00%

    A DHODH inhibitor

  • GC32931 structure
    GC32931LDH-IN-1
    CAS: 1964515-43-2
    纯度: >99.50%

    LDH-IN-1是一种新的基于吡唑的人乳酸脱氢酶(LDH)抑制剂，对于LDHA和LDHB的IC50值分别为32和27nM。

  • GC32993 structure
    GC32993(S)-GNE-140
    CAS: 2003234-64-6
    纯度: >99.00%

    (S)-GNE-140是活性较小的GNE-140的对映体，能够抑制乳酸脱氢酶A(LDHA)。

  • GC34011 structure
    GC34011FX-11 (LDHA Inhibitor FX11)
    CAS: 213971-34-7
    纯度: >98.00% / >97.00%

    FX-11（LDHA 抑制剂 FX11）被发现是一种有效的竞争性人 LDH-A 的 NADH 结合口袋抑制剂。

  • GC35106 structure
    GC351063-Dehydrotrametenolic acid
    CAS: 29220-16-4
    纯度: >98.00%

    3-Dehydrotrametenolic acid，分离于茯苓菌核，是一种乳酸脱氢酶 (LDH) 抑制剂。3-Dehydrotrametenolic acid 促进体外脂肪细胞分化，在体内起胰岛素增敏剂的作用。3-Dehydrotrametenolic acid 诱导细胞凋亡，具有抗癌活性。

  • GC38463 structure
    GC38463ASLAN003
    CAS: 1035688-66-4
    纯度: >99.50%

    A DHODH inhibitor

  • GC38604 structure
    GC38604Glomeratose A
    CAS: 202471-84-9
    纯度: >99.50%

    Glomeratose A 是一种乳酸脱氢酶 lactate dehydrogenase 抑制剂，是从远志 Polygala tenuifolia 分离的。

  • GC39279 structure
    GC39279hDHODH-IN-1
    CAS: 1173715-42-8
    纯度: >99.50%

    hDHODH-IN-1 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with anti-inflammatory effect.

  • GC39392 structure
    GC39392Isomalt
    CAS: 64519-82-0
    纯度: >98.00%

    Isomalt (Palatinitol) is a sugar alcohol used as an excipient in commercially available solid oral dosage forms. Isomalt stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying.

  • GC50151 structure
    GC50151NHI 2
    CAS: 1269802-97-2

    An inhibitor of LDHA

  • GC63795 structure
    GC63795LDHA-IN-3
    CAS: 227010-33-5
    纯度: >99.50%

    LDHA-IN-3 作为一种硒苯化合物，是一种有效的非竞争性乳酸脱氢酶(LDHA) 抑制剂(IC50=145.2 nM)。LDHA-IN-3 可用于癌症研究。

  • GC68710 structure
    GC68710AXKO-0046 dihydrochloride
    纯度: >99.00%

    AXKO-0046 dihydrochloride，吲哚衍生物，是 LDHB 选择性抑制剂。AXKO-0046 dihydrochloride 具有 LDHB 抑制活性，EC50 值为 42 nM。AXKO-0046 dihydrochloride 可用于癌症代谢的研究。

  • GC70681 structure
    GC70681Nedosiran sodium
    CAS: 2247026-22-6
    纯度: 不显示

    Nedosiran sodium是一种GalNAc-dsRNA偶联物，旨在抑制肝乳酸脱氢酶(LDH)酶的产生。

  • GC73684 structure
    GC73684CHK-336
    CAS: 2743436-86-2
    纯度: >98.00%

    CHK-336（实施例1）是一种口服活性LDHA抑制剂（IC50＜1nM），其抑制小鼠肝细胞中乳酸的产生。