MAPK Signaling(MAPK信号通路)

Cat.No. 产品名称 Information

GC48920 β-Carboline-1-carboxylic Acid

1-Formic Acid-β-carboline

An alkaloid with diverse biological activities

GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol

(±)214,15EG

A cytochrome P450 metabolite of 2-AG

GC60393 (-)-Zuonin A

表加巴辛,D-Epigalbacin

(-)-ZuoninA(D-Epigalbacin)是一种天然木质素，是有效的、选择性的JNKs抑制剂，对JNK1、JNK2和JNK3作用的IC50值分别为1.7μM,2.9μM和1.74μM。

GC73214 (3S,4R)-GNE-6893 (3S,4R)-GNE-6893是一种强效的口服活性HPK1抑制剂。

GC13944 (5Z)-7-Oxozeaenol

FR148083,L-783,279,LL-Z 1640-2

A selective TAK1 inhibitor

GC63903 (E)-Osmundacetone

(E)-紫萁酮

(E)-Osmundacetone 是 Osmundacetone 的异构体。Osmundacetone 可以显着抑制 MAPK 磷酸化，包括 JNK，ERK 和 p38 激酶，具有抗氧化应激的神经保护作用。

GC72756 (E/Z)-Necrosulfonamide (E/Z)-Necrosulfonamide是Necrosulfonamide的外消旋化合物。

GC73312 (R)-STU104 (R)-STU104是一种有效的口服TAK1-MKK3相互作用抑制剂，对TNF-α和MKK3磷酸化的ic50分别为0.58 μM和4.0 μM。

GC73082 (R)-VX-11e (R)-VX-11e化合物1是ERK2抑制剂。

GC62528 (Rac)-Hesperetin

3′,5,7-三羟基-4-甲氧基黄酮

(Rac)-Hesperetin 是Hesperetin 的外消旋体。 Hesperetin 是一种天然黄烷酮类物质，为有效的，广谱的人 UGT 抑制剂。Hesperetin 可通过激活 p38 MAPK 来诱导凋亡。

GC73433 (S)-BAY 2965501 (S)-BAY 2965501是BAY 2965501的左旋异构体。

GC41740 (S)-p38 MAPK Inhibitor III

(S)-p38 MAP Kinase Inhibitor III, (S)-p38 Mitogen-activated Protein Kinase Inhibitor III

A cell-permeable p38 MAP kinase inhibitor

GC12851 10Z-Hymenialdisine

2,5-已炔二醇,(Z)-Hymenialdisine; Hymenialdisine

A natural alkaloid that inhibits MEK-1 and other kinases

GC46554 2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate

2’-O-Succinyl-cAMP, 2’-O-Succinyl-3’,5’-cyclic AMP

An immunogenic derivative of cAMP

GC39325 2,5-Dihydroxyacetophenone

2,5-二羟基苯乙酮; 2',5'-二羟基苯乙酮

2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers is used in food flavouring. 2',5'-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression. 2',5'-Dihydroxyacetophenone significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways.

GC73085 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles是骨形态发生蛋白2（BMP2）的抑制剂，IC50为2.2μM。

GC35132 4-Hydroxylonchocarpin

异补骨脂色烯查耳酮

4-Hydroxylonchocarpin 是一种查尔酮化合物，来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK，JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性，包括抗菌，抗癌，抗逆转录酶，抗结核，抗疟，抗炎和抗氧化活性。

GC48381 5'-pApA (sodium salt)

c-di-AMP Control, Cyclic di-AMP Negative Control

A linearized form of cyclic di-AMP

GC63700 5,6,7-Trimethoxyflavone

黄岑素-5,6,7-三甲醚,Baicalein trimethyl ether

5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.

GC41423 5-trans Prostaglandin E2

transDinoprostone, 5,6trans PGE2

An impurity in commercial lots of PGE₁

GC12834 6-Bnz-cAMP sodium salt

6-Bnz-cAMP

A PKA-selective activator

GC42616 7-oxo Staurosporine

BMY 41950, RK-1409

An antibiotic with diverse biological activities

GC16929 8-Bromo-cAMP, sodium salt

8-溴腺苷-3',5'-环单磷酸钠,8-Br-Camp sodium salt

8-Bromo-cAMP (8-Bromo-cAMP, sodium salt)是一种细胞渗透性cAMP类似物，是cAMP依赖性蛋白激酶激活剂（PKA激活剂）,它能抑制肿瘤细胞生长，促进肿瘤分化。

GC42622 8-bromo-Cyclic AMP

8-溴腺苷-3',5'-环单磷酸

A PKA activator

GC64460 8-Chloro-cAMP

8-氯腺苷-3',5'-环状磷酸钠盐

8-Chloro-cAMP 是一种 cAMP 类似物，可诱导生长停滞，并调节 cAMP 依赖性 PKA 活性。8-Chloro-cAMP 具有抗癌活性。

GC15352 8-CPT-Cyclic AMP (sodium salt)

8-(4-硫代氯苯基)腺苷-3',5'-环状磷酸钠,8-(p-Chlorophenylthio)-cAMP,8-CPT-cAMP

A cell-permeable cAMP analog

GC60037 A-3 hydrochloride

赤霉酸

A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 ?M), casein kinase II (CK2) (Ki=5.1 ?M) and myosin light chain kinase (MLCK) (Ki=7.4 ?M), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 ?M and 80 ?M, respectively.

GA20623 Ac-muramyl-Ala-D-Glu-NH₂

佐剂肽

Ac-muramyl-Ala-D-Glu-NH₂ (MDP) 是一种合成的免疫反应肽，由连接到 L-Ala-D-isoGln 短氨基酸链上的 N-乙酰胞壁酸组成。

GC68597 ACA-28 ACA-28 (compound 2a) 是一种有效的 ERK MAPK 信号调节剂。ACA-28 通过 ERK 过度激活诱导凋亡，选择性抑制癌细胞生长。ACA-28 抑制黑色素瘤细胞 (SK-MEL-28) 和正常黑色素细胞 (NHEM) 生长，IC50 值分别为 5.3 和 10.1 μM。

GC35242 Actein

黄肉楠碱

Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖，诱导自噬和凋亡。Actein 在体内几乎没有毒性。

GC19019 Acumapimod

BCT197

An inhibitor of p38α MAPK

GC32797 AD80 AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.

GC90794 Adenosine 5'-methylenediphosphate (sodium salt)

Adenosine 5'-(α,β-methylene)diphosphate, AMP-CP, APCP, 5'-APCP

一种外切5'-核苷酸酶的抑制剂

GC49285 Adenosine 5’-methylenediphosphate (hydrate)

Adenosine 5'-(α,β-methylene)diphosphate, AMP-CP, APCP, 5'-APCP

An inhibitor of ecto-5’-nucleotidase

GC46808 ADTL-EI1712 A dual ERK1 and ERK5 inhibitor

GC10204 AEG 3482

6-苯基咪唑并[2,1-B]-1,3,4-噻二唑-2-磺酰胺

An inhibitor of p75^NTR- and NRAGE-induced apoptosis

GC17265 AG-126

酪氨酸磷酸化抑制剂126,Tyrphostin AG-126

Tyrosine kinase inhibitor that blocks ERK1/2 phosphorylation

GC12646 AL 8697 AL 8697 是一种具有口服活性的特异性 p38α MAPK 抑制剂，IC50 为 6 nM。

GC14899 AMG 548 An inhibitor of p38α MAPK

GC38518 AMG-548 dihydrochloride An inhibitor of p38α MAPK

GC48870 Anagrelide-13C3

BL 4162A-13C3, BMY 26538-01-13C3

An internal standard for the quantification of anagrelide

GC65917 Andrograpanin Andrograpanin 是来自穿心莲的活性化合物，具有抗炎和抗感染性能。

GC11559 Anisomycin

茴香霉素; Flagecidin; Wuningmeisu C

Anisomycin是一种从灰链霉菌中分离出来的抗生素，也是一种JNK激活剂。

GC68671 Anti-inflammatory agent 35 Anti-inflammatory agent 35 (化合物 5a27) 是一种口服有效的姜黄素类似物，具有抗炎活性。Anti-inflammatory agent 35 可阻断丝裂原活化蛋白激酶 (MAPK) 信号和 NF-kB 的核易位。Anti-inflammatory agent 35 还抑制黄中性粒细胞浸润和促炎细胞因子产生。Anti-inflammatory agent 35 在体内研究中显著减轻脂多糖 (LPS) 诱导的急性肺损伤 (ALI)。

GC15240 APS-2-79 An inhibitor of KSR-dependent MAPK signaling

GC60592 APS6-45 APS6-45(Compound 10) is an orally active tumor-calibrated inhibitor (TCI) that inhibits RAS/MAPK signaling and exhibits antitumor activity.