GlpBio

MAPK Signaling

MAPK Signaling(MAPK信号通路)

研究方向

MAPK Signaling 相关产品(575)

  • GC10030 structure
    GC10030EHop-016
    CAS: 1380432-32-5
    纯度: >99.00%

    EHop-016是一种高效的Rac GTP酶Rac1抑制剂，IC 50 值为1.1μM。

  • GC10033 structure
    GC10033Cobimetinib
    CAS: 934660-93-2
    纯度: >99.50%

    Cobimetinib是一种强效、选择性的MEK1抑制剂，IC 50 值为0.9nM。

  • GC10069 structure
    GC10069NSC 23766 trihydrochloride
    CAS: 1177865-17-6
    纯度: >99.50% / >99.00%

    NSC 23766 trihydrochloride是一种选择性Rac1 GTPase抑制剂，通过特异性阻断Rac1的鸟嘌呤核苷酸交换因子Trio和Tiam1来抑制Rac1的激活，对Rac1的IC₅₀约为50μM。

  • GC10110 structure
    GC10110PD318088
    CAS: 391210-00-7
    纯度: >99.50%

    An allosteric inhibitor of MEK1

  • GC10446 structure
    GC10446CC-930
    CAS: 899805-25-5
    纯度: >99.50%

    A potent JNK inhibitor

  • GC10528 structure
    GC10528Salirasib
    CAS: 162520-00-5
    纯度: >98.00%

    A Ras inhibitor with anti-cancer and anti-atherogenic activity

  • GC10693 structure
    GC10693c-JUN peptide
    CAS: 610273-01-3

    JNK/c-Jun interaction inhibitor

  • GC10941 structure
    GC10941cAMPS-Rp, triethylammonium salt
    CAS: 151837-09-1
    纯度: >99.00%

    A non-hydrolyzable analog of cAMP

  • GC11599 structure
    GC11599B-Raf inhibitor 1
    CAS: 1093100-40-3
    纯度: >98.00%

    An inhibitor of Raf kinases

  • GC11649 structure
    GC11649MLN 2480
    CAS: 1096708-71-2
    纯度: >98.50%

    An oral pan-Raf kinase inhibitor

  • GC11685 structure
    GC11685GW5074
    CAS: 220904-83-6
    纯度: >99.00%

    A potent inhibitor of Raf-1

  • GC11890 structure
    GC11890SB590885
    CAS: 405554-55-4
    纯度: >98.00%

    A potent inhibitor of B-Raf

  • GC12151 structure
    GC12151B-Raf inhibitor
    CAS: 1315330-11-0
    纯度: >98.50%

    B-Raf inhibitor 是一种有效的双重 TGFβ-activated kinase 1 (TAK1) 和 mitogen-activated protein kinase kinase kinase 2 (MAP4K2) 抑制剂，IC50 分别为 41.1 nM 和 18.2 nM。

  • GC12482 structure
    GC12482BRAF inhibitor
    CAS: 918505-61-0
    纯度: >98.50%

    BRAF 抑制剂是从专利 WO/2011103196 A1 化合物 P-0850 中提取的 B-Raf 抑制剂。

  • GC12691 structure
    GC12691XMD17-109
    CAS: 1435488-37-1
    纯度: >98.00%

    A selective ERK5 inhibitor

  • GC12706 structure
    GC12706cAMPS-Sp, triethylammonium salt
    CAS: 73208-40-9

    cAMPS-Sp，三乙基铵盐，一种 cAMP 类似物，是一种有效的、竞争性 cAMP 诱导的 cAMP 依赖性 PKA I 和 II 的激活（Kis 分别为 12.5 μ；M 和 4.5 μ；M）拮抗剂。

  • GC12819 structure
    GC12819PD98059
    CAS: 167869-21-8
    纯度: >98.00%

    D98059是一种有效的选择性MEK抑制剂，IC50为2 μM。

  • GC12824 structure
    GC12824Dibutyryl-cAMP, sodium salt
    CAS: 16980-89-5
    纯度: >99.50% / >98.00% / >99.00%

    Dibutyryl-cAMP, sodium salt，又称为Bucladesine，是一种细胞膜可透性环核苷酸类似物，能模拟内源性cAMP的作用，并作为磷酸二酯酶抑制剂。

  • GC12843 structure
    GC12843MEK162 (ARRY-162, ARRY-438162)
    CAS: 606143-89-9
    纯度: >99.50%

    A MEK1/2 inhibitor

  • GC12882 structure
    GC12882AS 602801
    CAS: 848344-36-5
    纯度: >99.50%

    A selective, orally bioavailable JNK inhibitor

  • GC12926 structure
    GC12926VX-745
    CAS: 209410-46-8
    纯度: >99.00% / >98.00%

    A p38α MAPK inhibitor

  • GC12970 structure
    GC12970Furosemide
    CAS: 54-31-9
    纯度: >99.50% / >98.00%

    A loop diuretic and an inhibitor of NKCC1 and NKCC2

  • GC13115 structure
    GC13115VX-11e
    CAS: 896720-20-0
    纯度: >99.00%

    A selective ERK inhibitor

  • GC13286 structure
    GC13286ZM336372
    CAS: 208260-29-1

    An activator of the Raf-1 signalling pathway