GlpBio

MEK1/2

MEK1/2, also known as MAPKK (mitogen-activated protein kinase kinase), is a kinase enzyme which phosphorylates MAPK (mitogen-activated protein kinase).

MEK1/2 相关产品(64)

  • GC10033 structure
    GC10033Cobimetinib
    CAS: 934660-93-2
    纯度: >99.50%

    Cobimetinib是一种强效、选择性的MEK1抑制剂，IC 50 值为0.9nM。

  • GC10110 structure
    GC10110PD318088
    CAS: 391210-00-7
    纯度: >99.50%

    An allosteric inhibitor of MEK1

  • GC12819 structure
    GC12819PD98059
    CAS: 167869-21-8
    纯度: >98.00%

    D98059是一种有效的选择性MEK抑制剂，IC50为2 μM。

  • GC12843 structure
    GC12843MEK162 (ARRY-162, ARRY-438162)
    CAS: 606143-89-9
    纯度: >99.50%

    A MEK1/2 inhibitor

  • GC13412 structure
    GC13412Vemurafenib (PLX4032, RG7204)
    CAS: 918504-65-1
    纯度: >99.50% / >99.00%

    Vemurafenib (PLX4032, RG7204)是一种选择性的强效B-RAF抑制剂，对BRAF V600E 和c-RAF-1的IC 50 分别为31和48nM。

  • GC13508 structure
    GC13508Trametinib (GSK1120212)
    CAS: 871700-17-3
    纯度: >98.00% / >99.00%

    Trametinib (GSK1120212, JTP-74057) 是第二代 MEK 激酶小分子抑制剂。

  • GC14337 structure
    GC14337Cobimetinib (R-enantiomer)
    CAS: 934660-94-3

    Cobimetinib R-对映异构体是 Cobimetinib 活性较低的 R-对映异构体。 Cobimetinib 是一种有效的选择性 MEK 抑制剂。

  • GC14643 structure
    GC14643AZD8330
    CAS: 869357-68-6
    纯度: >99.00%

    A MEK1/2 inhibitor

  • GC14732 structure
    GC14732PLX-4720
    CAS: 918505-84-7
    纯度: >99.50%

    An orally-available inhibitor of the B-raf mutant B-Raf V600E

  • GC15260 structure
    GC15260Trametinib DMSO solvate
    CAS: 1187431-43-1
    纯度: >99.50%

    Trametinib DMSO solvate (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) 是一种具有口服活性的 MEK 抑制剂，抑制 MEK1 和 MEK2，IC50 约为 2 nM。 Trametinib DMSO solvate 激活自噬并诱导细胞凋亡。

  • GC15359 structure
    GC15359SL-327
    CAS: 305350-87-2
    纯度: >98.00%

    SL-327是MEK1和MEK2的选择性抑制剂，IC 50 值分别为0.18μM和0.22μM。

  • GC17426 structure
    GC17426Cobimetinib (racemate)
    CAS: 934662-91-6
    纯度: >99.50%

    Cobimetinib（消旋体）（GDC-0973 消旋体；XL518 消旋体）是 Cobimetinib 的消旋体。 Cobimetinib 是一种有效的选择性 MEK 抑制剂。

  • GC18050 structure
    GC18050Pimasertib (AS-703026)
    CAS: 1236699-92-5
    纯度: >99.50%

    A MEK1/2 inhibitor

  • GN10063 structure
    GN10063Arctigenin
    CAS: 7770-78-7
    纯度: >99.50%

    Arctigenin是一种天然木脂素化合物，已证实具有抗癌活性。Arctigenin具有强效的抗氧化、抗炎和抗病毒（甲型流感病毒）活性。

  • GC10397 structure
    GC10397PD0325901
    CAS: 391210-10-9
    纯度: >99.50%

    PD0325901是一种具口服活性、选择性和非ATP竞争性的丝裂原活化蛋白激酶激酶（MEK）抑制剂，IC 50 值为0.33nM。

  • GC11277 structure
    GC11277MEK inhibitor
    CAS: 334951-92-7
    纯度: >98.50%

    MEK 抑制剂是一种有效的 MEK 抑制剂，具有抗肿瘤效力。

  • GC12006 structure
    GC12006GDC-0994
    CAS: 1453848-26-4
    纯度: >99.00%

    A selective ERK1/2 inhibitor

  • GC12220 structure
    GC12220BIX 02189
    CAS: 1265916-41-3
    纯度: >99.50%

    An inhibitor of MEK5 and ERK5

  • GC12406 structure
    GC12406RO5126766(CH5126766)
    CAS: 946128-88-7
    纯度: >98.00%

    A dual inhibitor of MEK1 and Raf kinases

  • GC12851 structure
    GC1285110Z-Hymenialdisine
    CAS: 82005-12-7

    A natural alkaloid that inhibits MEK-1 and other kinases

  • GC12989 structure
    GC12989PD184352 (CI-1040)
    CAS: 212631-79-3
    纯度: >99.50%

    A potent MEK inhibitor

  • GC14647 structure
    GC14647SCH772984 HCl

    A selective inhibitor of ERK1/2

  • GC15044 structure
    GC15044SCH772984 TFA

    A selective inhibitor of ERK1/2

  • GC15061 structure
    GC15061U0124
    CAS: 108923-79-1

    An inactive analog of U-0126