GlpBio

MAP3K

MAP3Ks (Mitogen-activated protein kinase kinase kinases), the top components of MAPK cascades, modulate many biological processes, such as growth, development and various environmental stresses. Based on the sequence of their kinase catalytic domain, MAP3Ks are classified into three groups: the MEKK-like, ZIK-like and Raf-like families. Raf-like MAP3Ks constitute largest MAP3K subfamily. Raf-like MAP3Ks play roles in response to biotic and abiotic stresses.

MAP3Ks often bind to both MAP4Ks and MAP2Ks in the same pathway. For example, MEKK1 (MAP3K1) binds to both the MAP4K NIK and the MAP2K MKK4, while NSY-1 (MAP3K) binds to the MAP2K SEK-1. MAP3Ks activates MAP2Ks by phosphorylation of a serine and/or threonine, and MAP2Ks activate MAPKs by dual phosphorylation of a Thr-X-Tyr motif.

MAP3K 相关产品(20)

  • GC12124 structure
    GC12124Selonsertib (GS-4997)
    CAS: 1448428-04-3
    纯度: >98.50%

    An ASK1 inhibitor

  • GC12151 structure
    GC12151B-Raf inhibitor
    CAS: 1315330-11-0
    纯度: >98.50%

    B-Raf inhibitor 是一种有效的双重 TGFβ-activated kinase 1 (TAK1) 和 mitogen-activated protein kinase kinase kinase 2 (MAP4K2) 抑制剂，IC50 分别为 41.1 nM 和 18.2 nM。

  • GC13514 structure
    GC13514NG25
    CAS: 1315355-93-1
    纯度: >98.00%

    NG25是一种强效且可渗透细胞的TGF-β-活化蛋白激酶1（TAK1）和丝裂原激活蛋白激酶激酶激酶激酶2（MAP4K2）抑制剂，IC 50 值分别为149nM和21.7nM。

  • GC13944 structure
    GC13944(5Z)-7-Oxozeaenol
    CAS: 66018-38-0,253863-19-3
    纯度: >99.00%

    A selective TAK1 inhibitor

  • GC14853 structure
    GC14853TC ASK 10
    CAS: 1005775-56-3
    纯度: >99.00%

    A inhibitor of ASK1

  • GC17577 structure
    GC17577NQDI 1
    CAS: 175026-96-7

    A selective inhibitor of ASK1

  • GC19041 structure
    GC19041ASK1-IN-1
    CAS: 1262041-49-5
    纯度: >99.50%

    ASK1-IN-1 是一种有效的、口服的、选择性的 ATP 竞争性凋亡信号调节激酶 1 (ASK1) 抑制剂，IC50 为 2.87 nM。

  • GC19173 structure
    GC19173GNE-3511
    CAS: 1496581-76-0
    纯度: >99.50%

    A selective and highly potent inhibitor of DLK

  • GC30913 structure
    GC30913DLK-IN-1
    CAS: 1620574-24-4
    纯度: >99.00%

    DLK-IN-1是双亮氨酸拉链激酶(DLK,MAP3K12)的选择性抑制剂，其Ki值为3nM。DLK-IN-1保持着良好的中枢神经系统穿透能力，并且在脑内剂量过量后依旧耐受性良好，在阿尔兹海默症动物模型中有良好的活性。

  • GC32687 structure
    GC32687Takinib
    CAS: 1111556-37-6
    纯度: >98.00%

    A TAK1 inhibitor

  • GC35734 structure
    GC35734Cot inhibitor-1
    CAS: 915365-57-0
    纯度: >98.00%

    Cot 抑制剂-1是COT/Tpl2抑制剂。

  • GC35735 structure
    GC35735Cot inhibitor-2
    CAS: 915363-56-3
    纯度: >99.00%

    Cot 抑制剂-2是COT/Tpl2抑制剂。

  • GC45067 structure
    GC45067Tpl2 Kinase Inhibitor
    CAS: 871307-18-5
    纯度: >95.00%

    Tpl2 Kinase Inhibitor（TKI）是一种可透过细胞膜的萘啶化合物，作为Tpl2激酶强效可逆的，ATP竞争性的抑制剂。

  • GC49150 structure
    GC49150Tpl2 Kinase Inhibitor (hydrochloride)
    纯度: >98.00%

    A Tpl2 inhibitor

  • GC62426 structure
    GC62426ASK1-IN-2
    CAS: 2541792-70-3
    纯度: >98.00%

    ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM.

  • GC62497 structure
    GC62497TAK1-IN-2
    CAS: 2763213-98-3
    纯度: >98.00%

    TAK1-IN-2 是一种有效和选择性的 TAK1 抑制剂，IC50> 值为 2 nM。

  • GC62675 structure
    GC62675SM1-71
    CAS: 2088179-99-9

    SM1-71 是一种有效的 TAK1 抑制剂，Ki 值为 160 nM，同时可以共价抑制 MKNK2、MAP2K1/2/3/4/6/7、GAK、AAK1、BMP2K、MAP3K7、MAPKAPK5、GSK3A/B、MAPK1/3、SRC、YES1、FGFR1、ZAK (MLTK)、MAP3K1、LIMK1 和 RSK2。SM1-71 在体外抑制多种癌细胞系的增殖。

  • GC63144 structure
    GC63144PF-05381941
    CAS: 1474022-02-0
    纯度: >99.50%

    PF-05381941 是一种有效的 TAK1/p38α 双抑制剂，IC50 值分别为 156 和 186 nM。

  • GC69984 structure
    GC69984TAK1-IN-4
    CAS: 1570374-32-1
    纯度: >99.00%

    TAK1-IN-4 (Compound 14) 是一种 TAK1 抑制剂。

  • GC70391 structure
    GC70391GNE-8505
    CAS: 1620573-48-9
    纯度: >99.00%

    GNE-8505是一种口服双亮氨酸拉链激酶（DLK）抑制剂。