JNK
JNK(c-Jun N-末端激酶)
JNK (c-Jun N-terminal kinase) is a group of kinases belong to the mitogen-activated protein kinase family and also play a role in T cell differentiation and the cellular apoptosis pathway.
JNK 相关产品(60)
- GA20623Muramyl dipeptideCAS: 53678-77-6纯度: >99.00%
Muramyl dipeptide (MDP)，是一种合成的免疫反应肽 (immunoreactive peptide)，由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。
- GC13724JIP-1 (153-163)CAS: 438567-88-5
JIP-1 (153-163) (TI-JIP) 是 c-JNK 的肽抑制剂，基于 JNK-interacting protein-1 (JIP-1) 的残基 153-163（修改：Phe-11 \u003d C-末端酰胺）。
- GC17658GuggulsteroneCAS: 95975-55-6纯度: >99.50%
Guggulsterone是一种从植物Commiphora wightii的树脂中提取的植物甾醇。Guggulsterone可以抑制多种肿瘤细胞的生长，并通过下调抗凋亡基因产物（IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP和survivin）、调节细胞周期蛋白（如Cyclin D1和c-Myc）、激活半胱氨酸蛋白酶、抑制Akt以及激活JNK来诱导细胞凋亡。
- GC20007Ginsenoside CKCAS: 39262-14-1纯度: >98.00%
Ginsenoside CK，一种由主要人参皂苷化合物转化而来的次级人参皂苷，比其母体人参皂苷具有更高的生物利用度和溶解性，具有极其重要的意义。
- GC25521IMM-H007CAS: 1221412-23-2
IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux.
- GC25982Tanzisertib(CC-930)CAS: 899805-25-5(freebase)纯度: >98.00%
Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC10446 | CC-930 | 899805-25-5 | >99.50% | |
A potent JNK inhibitor | ||||
| GC10693 | c-JUN peptide | 610273-01-3 | - | |
JNK/c-Jun interaction inhibitor | ||||
| GC12882 | AS 602801 | 848344-36-5 | >99.50% | |
A selective, orally bioavailable JNK inhibitor | ||||
| GC13841 | JNK-IN-8 | 1410880-22-6 | >99.50% | |
JNK-IN-8 是第一个不可逆的JNK抑制剂,作用于JNK1,JNK2和JNK3,具有高度特异性,在A375细胞系中IC50分别为4.7 nM,18.7 nM和1 nM。 | ||||
| GC14114 | DB07268 | 929007-72-7 | >99.50% | |
A potent inhibitor of JNK1 | ||||
| GC14197 | CC-401 hydrochloride | 1438391-30-0 | >99.50% | |
A potent, specific pan-JNK inhibitor | ||||
| GC15028 | JNK-IN-7 | 1408064-71-0 | >98.00% | |
A non-selective JNK inhibitor | ||||
| GC15344 | SP 600125 | 129-56-6 | >98.00% | |
SP 600125是一种具有口服活性的、可逆的、具有选择性的ATP竞争性JNK 抑制剂，对JNK1、JNK2和JNK3的IC 50 分别为40、40和90nM。SP 600125常用于卵巢癌、肿瘤、帕金森病 (PD)、乳腺癌和哮喘的研究。 | ||||
| GA20623 | Muramyl dipeptide | 53678-77-6 | >99.00% | |
Muramyl dipeptide (MDP)，是一种合成的免疫反应肽 (immunoreactive peptide)，由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。 | ||||
| GC10010 | AS601245 | 345987-15-7 | >98.50% | |
AS601245是一种强效的ATP竞争性JNK抑制剂，对JNK1、JNK2和JNK3的IC 50 值分别为0.15µM、0.22µM和0.07µM。 | ||||
| GC11157 | LL-Z 1640-4 | 66018-41-5 | - | |
A negative control for MAPK signaling | ||||
| GC11542 | SU 3327 | 40045-50-9 | >98.50% | |
A JNK1 inhibitor with antidiabetic and antibiotic activity | ||||
| GC11559 | Anisomycin | 22862-76-6 | >98.50% / >98.00% | |
Anisomycin是一种从灰链霉菌中分离出来的抗生素，也是一种JNK激活剂。 | ||||
| GC12841 | CEP 1347 | 156177-65-0 | - | |
CEP 1347 是一种具有神经保护作用的 JNK/SAPK 通路抑制剂。 | ||||
| GC13244 | DTP3 | 1809784-29-9 | >99.00% | |
DTP3 TFA 是一种有效的选择性 GADD45β/MKK7 抑制剂。 DTP3 TFA 靶向 NF-κB 通路下游的一个重要的癌症选择性细胞存活模块。 | ||||
| GC13724 | JIP-1 (153-163) | 438567-88-5 | - | |
JIP-1 (153-163) (TI-JIP) 是 c-JNK 的肽抑制剂，基于 JNK-interacting protein-1 (JIP-1) 的残基 153-163（修改：Phe-11 \u003d C-末端酰胺）。 | ||||
| GC14938 | PF-03394197(Oclacitinib) | 1208319-26-9 | - | |
A JAK family kinase inhibitor | ||||
| GC16652 | SR 3576 | 1164153-22-3 | - | |
A JNK3 inhibitor | ||||
| GC17282 | TCS JNK 6o | 894804-07-0 | >99.50% / >98.00% | |
A JNK inhibitor | ||||
| GC17658 | Guggulsterone | 95975-55-6 | >99.50% | |
Guggulsterone是一种从植物Commiphora wightii的树脂中提取的植物甾醇。Guggulsterone可以抑制多种肿瘤细胞的生长，并通过下调抗凋亡基因产物（IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP和survivin）、调节细胞周期蛋白（如Cyclin D1和c-Myc）、激活半胱氨酸蛋白酶、抑制Akt以及激活JNK来诱导细胞凋亡。 | ||||
| GC20007 | Ginsenoside CK | 39262-14-1 | >98.00% | |
Ginsenoside CK，一种由主要人参皂苷化合物转化而来的次级人参皂苷，比其母体人参皂苷具有更高的生物利用度和溶解性，具有极其重要的意义。 | ||||
| GC25521 | IMM-H007 | 1221412-23-2 | - | |
IMM-H007, an adenosine derivative, is an activator of AMP-Activated Protein Kinase (AMPK). IMM-H007 is a potential drug for treating cardiac dysfunction. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 (ATP binding cassette subfamily a member 1) degradation and facilitates its cell-surface localization in macrophages, thereby promotes cholesterol efflux. | ||||
| GC25982 | Tanzisertib(CC-930) | 899805-25-5(freebase) | >98.00% | |
Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively. | ||||
| GC30057 | D-JNKI-1 (AM-111) | 1445179-97-4 | - | |
D-JNKI-1 (AM-111) (AM-111) 是一种高效且可渗透细胞的 JNK 肽抑制剂。 | ||||