SR 3576

目录号: GC16652纯度: >98%

A JNK3 inhibitor

Cas No.: 1164153-22-3

规格	价格	库存	数量	操作
10mg	¥2,867.00	现货	1
50mg	¥12,044.00	现货	1

文献被引

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SR-3576 is a cell-permeable, potent and selective JNK3 (c-Jun N-terminal kinase 3) inhibitor.

SR-3576 is a small molecule inhibitor belonging to aminopyrazole class that selectively inhibits JNK3 with >2800 fold selectively over p38.

Cell experiment[1]:
Cell lines	Human ovarian cancer cisplatin-resistant SKOV3/DDP cells
Preparation method	The solubility of this compound in DMSO is > 10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition	24 h, 2 μM
Applications	SR 3576 is a specific inhibitor of JNK3. Inhibition of JNK3 by SR 3576 exacerbates oxidative stress and suppresses autophagic flux, resulting in an increase of apoptosis induced by S1 in human ovarian cancer SKOV3/DDP cells.
References: [1]. Yang X, Xiang X, Xia M, et al. Inhibition of JNK3 promotes apoptosis induced by BH3 mimetic S1 in chemoresistant human ovarian cancer cells[J]. The Anatomical Record, 2015, 298(2): 386-395.

Purity:>98%

CAS 号

1164153-22-3

化学名

3-(4-(3-(m-tolyl)ureido)-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide

SMILES

O=C(C1=CC(N2N=CC(NC(NC3=CC=CC(C)=C3)=O)=C2)=CC=C1)NC(C=C4OC)=CC(OC)=C4OC

分子式

C₂₇H₂₇N₅O₅

分子量

501.53 g/mol

溶解性

<50.15mg/ml in DMSO

保存条件

Store at -20°C

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。

Shipping Condition

评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

质量 (Mass)

体积 (Volume)

浓度 (Concentration)

分子量 (MW)

g/mol