MAPKAPK2 (MK2)
MAP kinase-activated protein kinase 2 (MAPKAPK2) is an enzyme that in humans is encoded by the MAPKAPK2 gene. MAPKAP kinase-2 (MK2) is originally identified by its phosphorylation of glycogen synthase at serine-7 and the corresponding serine in a peptide (GS peptide-1) modelled after the N-terminus of glycogen synthase.
MAPKAP kinase-2 is a novel protein kinase activated by mitogen-activated protein kinase. This MAP kinase activated protein kinase, termed MAPKAP kinase-2, is distinguished from S6 kinase-II (MAPKAP kinase-1) by its response to inhibitors, lack of phosphorylation of S6 peptides and amino acid sequence.
MAPKAPK2 (MK2) 相关产品(9)
- GC14645PF-3644022CAS: 1276121-88-0纯度: >99.50%
PF-3644022 是一种有效的、选择性的、具有口服活性和 ATP 竞争性的 MAPKAPK2 (MK2) 抑制剂，IC50 为 5.2 nM，Ki 为 3 nM。
- GC33142MK2-IN-1 (MK2 Inhibitor)CAS: 1314118-92-7
MK2-IN-1 (MK2 Inhibitor) 是一种有效的、选择性的 MAPKAPK2(MK2) 抑制剂 (IC50=0.11 uM)，具有非 ATP 竞争性结合模式。
- GC63425ZunsemetinibCAS: 1640282-42-3纯度: ≥99.00%
Zunsemetinib (CDD-450) 是一种具有口服活性的 p38α 丝裂原激活蛋白激酶激活蛋白激酶2 (MK2)通路抑制剂。Zunsemetinib 可用于免疫炎症性疾病的研究。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC11180 | CMPD-1 | 41179-33-3 | >99.00% | |
A substrate-selective p38α MAPK inhibitor | ||||
| GC14645 | PF-3644022 | 1276121-88-0 | >99.50% | |
PF-3644022 是一种有效的、选择性的、具有口服活性和 ATP 竞争性的 MAPKAPK2 (MK2) 抑制剂，IC50 为 5.2 nM，Ki 为 3 nM。 | ||||
| GC16723 | MK2 Inhibitor IV | 1314118-94-9 | >98.50% | |
A highly selective MAPKAPK2 (MK2) inhibitor | ||||
| GC33142 | MK2-IN-1 (MK2 Inhibitor) | 1314118-92-7 | - | |
MK2-IN-1 (MK2 Inhibitor) 是一种有效的、选择性的 MAPKAPK2(MK2) 抑制剂 (IC50=0.11 uM)，具有非 ATP 竞争性结合模式。 | ||||
| GC44211 | MK2 Inhibitor III | 1186648-22-5 | >95.00% | |
A potent, cell-permeable inhibitor of MK2 | ||||
| GC61819 | MK2-IN-3 | 724711-21-1 | >98.00% | |
MK2 Inhibitor III (MK2-IN-3) is an ATP-competitive MK2 (MAPKAP-K2) inhibitor with an IC50 value of 8.5 nM. | ||||
| GC63425 | Zunsemetinib | 1640282-42-3 | ≥99.00% | |
Zunsemetinib (CDD-450) 是一种具有口服活性的 p38α 丝裂原激活蛋白激酶激活蛋白激酶2 (MK2)通路抑制剂。Zunsemetinib 可用于免疫炎症性疾病的研究。 | ||||
| GC63441 | CC-99677 | 1887069-10-4 | - | |
CC-99677 是一种有效的、共价的、不可逆的丝裂原活化蛋白 (MAP) 激酶活化蛋白激酶 -2 (MK2)通路抑制剂，在生化(IC50=156.3 nM) 和细胞基础检测 (EC50=89 nM) 中均有作用。CC-99677 来自专利 WO2020236636，化合物 1。 | ||||
| GC64580 | MMI-0100 | 1039342-24-9 | >99.00% | |
MMI-0100 是一种细胞渗透性肽抑制剂，抑制丝裂原活化蛋白激酶活化蛋白激酶 II (MK2)。MMI-0100 在体内外减少内膜增生。MMI-0100 抑制 IL-6 表达而不影响 IL-8 表达。MMI-0100 抑制纤维化过程，例如静脉移植疾病。 | ||||