MAPK Signaling(MAPK信号通路)

Cat.No. 产品名称 Information

GC72124 CREBtide TFA CREBtide TFA是一种类似CREB (cAMP反应元件结合蛋白)的肽。

GC43332 Cuspin-1

Chemical Upregulator of SMN Protein-1

An upregulator of SMN protein

GC50181 CW 008 PKA signaling activator; promotes osteogenesis from hMSCs

GC43341 Cyclic GMP

鸟苷-3ˊ,5ˊ-环磷酸一钠盐

A second messenger

GC68923 Cyclocurcumin Cyclocurcumin 是一种有效的 p38α 抑制剂。Cyclocurcumin 具有抗风湿、抗血管收缩和抗氧化活性。

GC30057 D-JNKI-1 (AM-111)

AM-111; XG-102

D-JNKI-1 (AM-111) (AM-111) 是一种高效且可渗透细胞的 JNK 肽抑制剂。

GC15187 Dabrafenib (GSK2118436)

达拉非尼; GSK2118436A; GSK2118436

A Raf kinase inhibitor

GC12486 Dabrafenib Mesylate (GSK-2118436)

甲磺酸达拉非尼; GSK2118436 Mesylate; GSK 2118436B

A Raf kinase inhibitor

GC47166 Dabrafenib-d9

达帕菲尼杂质,GSK2118436A-d9; GSK2118436-d9

An internal standard for the quantification of dabrafenib

GN10336 Daphnetin

瑞香素; 7,8-Dihydroxycoumarin

A coumarin derivative with diverse biological activities

GC68937 Darizmetinib Darizmetinib 是一种丝裂原活化蛋白激酶激酶 (MAP2K) 的抑制剂。

GC14114 DB07268

2-[[2-[(3-羟基苯基)氨基]-4-嘧啶基]氨基]苯甲酰胺,DB 07268;DB-07268

A potent inhibitor of JNK1

GC15477 DBM 1285 dihydrochloride p38 MAPK inhibitor

GC16795 DCA

二氯乙酸钠

DCA 是癌细胞中的代谢调节剂'；具有抗癌活性的线粒体。 DCA 抑制 PDHK，导致肿瘤微环境中的乳酸减少。 DCA 增加活性氧 (ROS) 生成并促进癌细胞凋亡。 DCA 也可作为 NKCC 抑制剂。

GC72910 DD1 DD1蛋白酶体抑制剂，靶向急性髓系白血病（AML）凋亡过程中Bax的激活和P70S6K的降解。

GC18666 Debromohymenialdisine

DBH, SKF 108753

An inhibitor of Chk1 and Chk2

GC35832 Dehydrocorydaline chloride

盐酸脱氢紫堇碱; 13-Methylpalmatine chloride

An alkaloid with diverse biological activities

GC16214 DEL-22379

N-[2,3-二氢-3-[(5-甲氧基-1H-吲哚-3-基)亚甲基]-2-氧代-1H-吲哚-5-基]-1-哌啶丙酰胺

An inhibitor of ERK dimerization

GC32254 Deltonin

三角叶薯蓣皂苷

Deltonin是从盾叶薯蓣中得到的甾体皂苷，能够抑制ERK1/2和AKT的活化，具有抗肿瘤的活性。

GC12824 Dibutyryl-cAMP, sodium salt

Dibutyryl cAMP sodium salt; DBcAMP sodium salt

Dibutyryl-cAMP, sodium salt，又称为Bucladesine，是一种细胞膜可透性环核苷酸类似物，能模拟内源性cAMP的作用，并作为磷酸二酯酶抑制剂。

GC38319 Dihydrocaffeic acid

二氢咖啡酸; 3,4-Dihydroxy-benzenepropanoic acid

A polyphenol with diverse biological activities

GC31697 Dilmapimod (SB-681323)

度马莫得; SB-681323; GW 681323

Dilmapimod (SB-681323,GW 681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.

GC47237 Dipyridamole-d16 A neuropeptide with diverse biological activities

GC30913 DLK-IN-1 DLK-IN-1是双亮氨酸拉链激酶(DLK,MAP3K12)的选择性抑制剂，其Ki值为3nM。DLK-IN-1保持着良好的中枢神经系统穿透能力，并且在脑内剂量过量后依旧耐受性良好，在阿尔兹海默症动物模型中有良好的活性。

GC61466 DMU-212

3,4,5,4'-四甲氧基二苯乙烯

DMU-212 is a methylated derivative of Resveratrol, with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities, which can induce mitotic arrest via induction of apoptosis and activation of extracellular-signal-regulated kinase1/2 (ERK1/2) protein.

GC65298 DMX-5804 DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively.

GC71195 DN-1289 DN-1289是一种口服活性和选择性的双亮氨酸拉链激酶（DLK；IC50=17 nM）和亮氨酸拉链携带激酶（LZK；IC5=40 nM）抑制剂。

GC69013 DS12881479 DS12881479 是一种有效的选择性 Mnk1 抑制剂，其 IC50 值为21 nM. DS12881479 可用于癌症研究。

GC69015 DS89002333 DS89002333 是一种口服有效的强效 PRKACA 抑制剂，其 IC50 值为 0.3 nM。DS89002333 在表达 DNAJB1-PRKACA 融合基因的 FL-HCC 患者源性异种移植模型中显示较好的抗肿瘤活性。DS89002333 可用于纤维化肝细胞癌 (FL-HCC) 的研究。

GC13244 DTP3 DTP3 TFA 是一种有效的选择性 GADD45β/MKK7 抑制剂。 DTP3 TFA 靶向 NF-κB 通路下游的一个重要的癌症选择性细胞存活模块。

GC38202 DTP3 TFA DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.

GC73118 EB1 EB1是MNK激酶的抑制剂，ic50值分别为0.69 μM （MNK1）和9.4 μM （MNK2）。

GC64496 EF24 EF24是一种新型合成姜黄素类似物。

GC10030 EHop-016 A Rac1 and Rac3 inhibitor

GC70927 Emprumapimod Emprumapimod (PF-07265803)是一种有效的口服选择性p38α MAPK抑制剂，可直接抑制lps诱导的RPMI-8226细胞产生IL-6 (IC50=100 pM)。

GC70928 Emprumapimod hydrochloride Emprumapimod hydrochloride是一种口服活性和选择性的p38α MAPK抑制剂。

GC69064 Endothelin-1 (1-31) (Human) TFA Endothelin-1 (1-31) (Human) TFA 是一种有效的血管收缩剂和血压升高剂。Endothelin-1 (1-31) (Human) TFA 来源于 chymase 对大 ET-1 的选择性水解。

GC43610 Enniatin A1

恩镰孢菌素 A1

An ionophore antibiotic

GC17693 Enniatin B

恩镰孢菌素 B

A natural inhibitor of Pdr5p in yeast

GC43611 Enniatin B1

恩镰孢菌素 B1

An antibiotic ionophore

GC10403 EO 1428

EO 1428, p38 MAP Kinase Inhibitor VIII, p38 Mitogen-activated Protein Kinase Inhibitor VIII

An inhibitor of p38α and p38β MAP kinases

GC43624 ERK Inhibitor

Extracellular Regulated Kinase Inhibitor

An ERK inhibitor

GC33206 ERK-IN-1 ERK-IN-1（化合物 B）是一种可口服的 ERK1 和 ERK2 抑制剂，用于治疗以激活 MAPK 通路突变为特征的增殖性疾病。该活性尤其与 KRAS 突变 NSCLC、BRAF 突变 NSCLC、KRAS 突变胰腺癌、KRAS 突变结直肠癌 (CRC) 和 KRAS 突变卵巢癌的治疗有关。 ERK-IN-1 hydrochloride 也可以抑制 RAF。

GC62229 ERK-IN-3

ERK-IN-3

ASN007(ERAS 007, ERK-IN-3) is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with 2 nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations.