• 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

qq在线咨询
Home >> Signaling Pathways >> TGF-β / Smad Signaling

TGF-β / Smad Signaling(TGF-β / Smad 信号转导)

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Products for  TGF-β / Smad Signaling

  1. Cat.No. 产品名称 Information
  2. GC13890 (±)-Palmitoylcarnitine chloride

    C16:0 Carnitine, CAR 16:0, DL-Carnitine hexadecanoyl ester, DL-Carnitine palmitoyl ester, Hexadecanoyl-DL-carnitine, DL-Hexadecanoylcarnitine, NSC 628323, DL-Palmitoylcarnitine

     A long-chain acylcarnitine with intracellular and extracellular roles
  3. GC10603 (-)-epicatechin gallate

    表儿茶素没食子酸酯; Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate

     A natural polyphenol with diverse protective actions
  4. GC17242 (-)-epigallocatechin

    (-)-表没食子儿茶素; Epigallocatechin; L-Epigallocatechin

     A green tea polyphenol
  5. GC14049 (-)-Epigallocatechin gallate (EGCG)

    (-)-表没食子儿茶素没食子酸酯,EGCG

     (-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。
  6. GC14012 (-)-Indolactam V

    吲哚内酰胺V,Indolactam V

     A PKC activator
  7. GC41737 (S)-Glycyl-H-1152 (hydrochloride)

    Rho Kinase Inhibitor IV

     A ROCK inhibitor
  8. GC70295 (S)-Ro 32-0432 (S)-Ro 32-0432是一种有效的、选择性的、atp竞争性的、口服活性PKC抑制剂。
  9. GC18062 1,2-Dilauroyl-sn-glycerol

    1,2-二月桂酰-SN-甘油,1,2-DLG

     A long-chain DAG
  10. GC14134 1,2-Dimyristoyl-sn-glycerol

    1,2-二肉豆蔻酸甘油酯,1,2-DMG

     A long-chain DAG
  11. GC13877 1,2-Dipalmitoyl-sn-glycerol

    1,2-双棕榈酸甘油酯,1,2-DPG,NSC 269964

     A diacylglycerol
  12. GC12662 1,2-Distearoyl-sn-glycerol

    1,2-Dioctadecanoyl-sn-glycerol,DSG

     A diacylglycerol
  13. GC12172 1-Naphthyl PP1

    4-氨基-1-叔丁基-3-(1'-萘基)吡唑并[3,4-D]嘧啶,1-NA-PP 1

     Inhibitor of modified ‘analog-sensitive’ kinases
  14. GC41863 10,11-dehydro Curvularin

    α,β-dehydro Curvularin

     A natural mycotoxin
  15. GN10444 12-O-tetradecanoyl phorbol-13-acetate

    佛波酯; PMA; TPA; Phorbol myristate acetate

    一种PKC激活剂
  16. GC73085 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles是骨形态发生蛋白2（BMP2）的抑制剂，IC50为2.2μM。
  17. GC17727 [Ala107]-MBP (104-118)

    肽抑制剂[ALA107]-MBP(104-118)

     [Ala107]-MBP (104-118) 是一种蛋白激酶 C (PKC) 的非竞争性肽抑制剂，IC50 范围为 46-145 μM。
  18. GC15345 [Ala113]-MBP (104-118)

    肽抑制剂[ALA113]-MBP(104-118)

     [Ala113]-MBP (104-118) 是一种蛋白激酶 C (PKC) 的非竞争性肽抑制剂，IC50 范围为 28-62 μM。
  19. GC13927 A 77-01

    A77-01;A-77-01

     A potent ALK5 inhibitor
  20. GC10166 A 83-01

    3-(6-甲基-2-吡啶基)-N-苯基-4-(4-喹啉基)-1H-吡唑-1-硫代甲酰胺,A83-01;A-83-01

     A 83-01 是 TGF-β I 型受体 ALK5 激酶、I 型淋巴结受体 ALK4 和 I 型淋巴结受体 ALK7 的有效抑制剂，IC50 s 分别为 12 nM、45 nM和 7.5 nM 分别抑制 ALK5、ALK4 和 ALK7 诱导的转录。
  21. GC35210 A 83-01 sodium salt

    3-(6-Methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide, sodium salt

    A TGF-β type I receptor inhibitor
  22. GC60037 A-3 hydrochloride

    赤霉酸

     A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 ?M), casein kinase II (CK2) (Ki=5.1 ?M) and myosin light chain kinase (MLCK) (Ki=7.4 ?M), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 ?M and 80 ?M, respectively.
  23. GC15579 Adaphostin

    NSC 680410

     Adaphostin (NSC 680410) 是 AG957 的金刚烷基酯，是一种有效的 p210bcr/abl 抑制剂 (IC50=14 μM)。 Adaphostin 在人 T 淋巴细胞白血病细胞系中诱导细胞凋亡（IC50 范围为 17 至 216 nM）。 Adaphostin 对慢性和急性髓性白血病细胞具有显着的选择性活性。 Adaphostin 增加了 CLL B 细胞内的活性氧 (ROS) 水平。
  24. GC16475 Afuresertib

    GSK2110183

     A pan-Akt inhibitor
  25. GC42747 Afuresertib (hydrochloride)

    GSK2110183 hydrochloride

     A pan-Akt inhibitor
  26. GC73739 AKE-72 AKE-72（化合物5）是Pan-BCR ABL的强效抑制剂。
  27. GC65294 ALK2-IN-2 ALK2-IN-2 是一种有效的、选择性的活化素受体样激酶 2 (ALK2) 抑制剂，IC50 值为 9 nM，对 ALK2 的抑制作用是 ALK3 的 700 倍。
  28. GC11050 ALK5 Inhibitor II (hydrochloride)

    E 616452,RepSox,SJN 2511

     A selective inhibitor of ALK5
  29. GC73338 ALK5-IN-34 ALK5-IN-34是一种选择性口服活性激活素受体样激酶（ALK）抑制剂。
  30. GC68679 Aprinocarsen sodium

    ISIS 3521 sodium

     Aprinocarsen (ISIS 3521) sodium，是蛋白激酶 C-α（PKC-α） 的特异性反义寡核苷酸抑制剂。Aprinocarsen sodium 是一种 20-mer 的寡核苷酸，它能调节细胞分化和增殖。Aprinocarsen sodium 可抑制人类肿瘤细胞系在裸鼠体内的生长。Aprinocarsen sodium 具有作为人类癌症化疗化合物的价值。
  31. GC34300 AR-13324 analog mesylate AR-13324类似物甲磺酸盐是AR-13324的类似物。
  32. GC19034 AR-13324 mesylate

    奈他地尔二甲磺酸盐

     AR-13324 是一种有效的 ROCK I 和 ROCK II 抑制剂，已被证明可在低浓度下诱导培养的人和猪 TM 细胞发生形态学变化。
  33. GC31959 AS2521780 AS2521780是新颖的PKCθ选择性抑制剂，IC50值为0.48nM。
  34. GC32703 Asciminib (ABL001)

    ABL001

     An allosteric inhibitor of Abl1
  35. GC64462 Asciminib hydrochloride

    阿思尼布盐酸盐,ABL001 hydrochloride

     An allosteric inhibitor of Abl1
  36. GN10534 Asiaticoside

    积雪草苷

     A saponin with significant wound healing activity
  37. GC10914 AST 487

    NVP-AST 487

     A multi-kinase inhibitor
  38. GC17712 AT13148 A multi-AGC kinase inhibitor
  39. GC10638 AT9283 A broad spectrum kinase inhibitor
  40. GC64815 Aurothiomalate sodium

    金硫丁二钠

     Aurothiomalate sodium 是一种有效的和选择性的致癌 PKCι 信号传导抑制剂。Aurothiomalate sodium 抑制肿瘤细胞增殖，而不抑制细胞凋亡。Aurothiomalate sodium 是一种有效的硫氧还蛋白还原酶 (TrxR) 抑制剂。Aurothiomalate sodium 是一种抗风湿剂，显示出有效的抗肿瘤活性。
  41. GC50589 AZ 12799734 AZ 12799734 是一种选择性的、口服活性的 TGFBR1 激酶抑制剂，IC50 为 47 nM。
  42. GC35442 Azaindole 1

    6-氯-N4-[3,5-二氟-4-[(3-甲基-1H-吡咯并[2,3-B]吡啶-4-基)氧]苯基]-2,4-嘧啶二胺,ROCK-IN-2?，TC-S 7001

     A ROCK1 and ROCK2 inhibitor
  43. GC35462 Bafetinib

    巴氟替尼; INNO-406; NS-187

     A Bcr-Abl inhibitor
  44. GC33343 BCR-ABL-IN-1 BCR-ABL-IN-1是一种BCR-ABL酪氨酸激酶抑制剂，pIC50值为6.46，可能用于慢性髓细胞白血病的研究。
  45. GC33368 BCR-ABL-IN-2 BCR-ABL-IN-2是BCR-ABL1激酶的抑制剂，其对ABL1native和ABL1T315I的IC50值分别为57nM，773nM。
  46. GC73614 BCR-ABL-IN-8 BCR-ABL-IN-8（化合物26f）是含有三甲氧基的BCR-ABL抑制剂。
  47. GC32868 BDP5290 BDP5290对MRCKβ、ROCK1、ROCK2的IC50值分别为17nM、230nM、123nM和100nM，是ROCK和MRCK的有效抑制剂。
  48. GC34493 BIBF0775 BIBF-0775 is a selective inhibitor of transforming growth factor β Receptor I (TGFβRI,Alk5) with an IC50 of 34nM.
  49. GC74516 Bintrafusp alfa

    M7824; MSB0011359C

     Bintrafusp alfa（M 7824）是一种一流的双功能融合蛋白，由TGF-βRII的细胞外结构域与阻断程序性细胞死亡配体的人IgG1单克隆抗体融合而成。
  50. GC62868 BIO-013077-01

    6-(3-(6-甲基吡啶-2-基)-1H-吡唑-4-基)喹噁啉

     BIO-013077-01 是一种吡唑类的 TGF-β 抑制剂。
  51. GC12135 Bisindolylmaleimide II

    双吲哚马来酰亚胺II,Bis II

     A PKC inhibitor

Items 1 to 50 of 360 total

per page
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction