TGF-β / Smad Signaling

TGF-β / Smad Signaling(TGF-β / Smad 信号转导)

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

研究方向

TGF-β / Smad Signaling 相关产品(360)

GC14349 SB525334
CAS: 356559-20-1
纯度: >99.50% / >98.00%
SB525334已被鉴定为一种高效且选择性的转化生长因子β1（TGF-β1）受体、活化素受体样激酶（ALK5）抑制剂。SB525334对ALK5激酶活性的IC 50 为14.3nM。
GC14363 Mitoxantrone HCl
CAS: 70476-82-3
纯度: >98.00%
An inhibitor of DNA topoisomerase IIα and HIV-1 integrase
GC14583 R 59-022
CAS: 93076-89-2
纯度: 不显示
R 59-022是一种二酰甘油激酶抑制剂（IC 50 = 2.8µM）。
GC14592 KW 2449
CAS: 1000669-72-6
纯度: >99.50%
A multi-kinase inhibitor
GC14650 CGP60474
CAS: 164658-13-3
纯度: >98.50%
A CDK inhibitor
GC14716 Bisindolylmaleimide IV
CAS: 119139-23-0
纯度: >98.50% / >97.00%
Bisindolylmaleimide IV 是一种强效的细胞膜透过性蛋白激酶C(PKC)抑制剂，其IC 50 值为0.1-0.55μM。
GC14767 PF-00562271
CAS: 939791-38-5
纯度: >99.00%
A selective FAK/PYK2 inhibitor
GC15018 Hispidin
CAS: 555-55-5
纯度: >99.50%
A polyphenol with diverse biological activities
GC15057 Kartogenin
CAS: 4727-31-5
纯度: >98.00%
Kartogenin是软骨样组织形成的诱导剂（EC 50 : 100 nM）。
GC15148 Ionomycin calcium salt
CAS: 56092-82-1
纯度: >98.00%
Ionomycin calcium salt是一种窄谱抗生素,对革兰氏阳性菌具有活性,由丛生链霉菌(Streptomyces conglobatus)产生。
GC15170 SB 772077B dihydrochloride
CAS: 607373-46-6
纯度: >98.50%
A ROCK1 and ROCK2 inhibitor
GC15345 [Ala113]-MBP (104-118)
CAS: 99026-78-5
[Ala113]-MBP (104-118) 是一种蛋白激酶 C (PKC) 的非竞争性肽抑制剂，IC50 范围为 28-62 μM。
GC15446 Ionomycin free acid
CAS: 56092-81-0
纯度: {{1-15}>98.00%}
Ionomycin free acid 是一种选择性的强效钙离子载体，可作为活性 Ca2+ 载体。
GC15471 PKC β pseudosubstrate
CAS: 172308-76-8
Selective cell-permeable peptide inhibitor of protein kinase C
GC15564 Go 6976
CAS: 136194-77-9
纯度: >99.00% / >98.00%
Go 6976 是一种有效的蛋白激酶(PKs)抑制剂，对PKC、cGMP依赖性蛋白激酶和肌球蛋白轻链激酶的IC 50 值分别为0.02μM、6.2μM和5.8μM。
GC15567 K02288
CAS: 1431985-92-0
纯度: >98.00%
A BMP signaling inhibitor
GC15884 Dasatinib Monohydrate
CAS: 863127-77-9
An inhibitor of Abl and Src
GC16289 SAR407899 hydrochloride
CAS: 923262-96-8
纯度: >98.00%
A ROCK1 and ROCK2 inhibitor
GC16405 Safingol
CAS: 15639-50-6
A dual inhibitor of PKC and SPHK
GC16475 Afuresertib
CAS: 1047644-62-1
纯度: >99.50%
A pan-Akt inhibitor
GC16510 ZIP, Biotinylated
ZIP with a biotin moiety covalently attached
GC16539 Butaprost
CAS: 69685-22-9
纯度: >98.00%
A selective agonist for the EP 2 receptors
GC16584 TCS 21311
CAS: 1260181-14-3
纯度: >95.00%
A JAK3 inhibitor
GC16678 UCN-02
CAS: 121569-61-7
A PKC inhibitor

分类产品列表
货号	产品名称	CAS号	纯度
GC14349	SB525334	356559-20-1	>99.50% / >98.00%
GC14349	SB525334已被鉴定为一种高效且选择性的转化生长因子β1（TGF-β1）受体、活化素受体样激酶（ALK5）抑制剂。SB525334对ALK5激酶活性的IC 50 为14.3nM。
GC14363	Mitoxantrone HCl	70476-82-3	>98.00%
GC14363	An inhibitor of DNA topoisomerase IIα and HIV-1 integrase
GC14583	R 59-022	93076-89-2	不显示
GC14583	R 59-022是一种二酰甘油激酶抑制剂（IC 50 = 2.8µM）。
GC14592	KW 2449	1000669-72-6	>99.50%
GC14592	A multi-kinase inhibitor
GC14650	CGP60474	164658-13-3	>98.50%
GC14650	A CDK inhibitor
GC14716	Bisindolylmaleimide IV	119139-23-0	>98.50% / >97.00%
GC14716	Bisindolylmaleimide IV 是一种强效的细胞膜透过性蛋白激酶C(PKC)抑制剂，其IC 50 值为0.1-0.55μM。
GC14767	PF-00562271	939791-38-5	>99.00%
GC14767	A selective FAK/PYK2 inhibitor
GC15018	Hispidin	555-55-5	>99.50%
GC15018	A polyphenol with diverse biological activities
GC15057	Kartogenin	4727-31-5	>98.00%
GC15057	Kartogenin是软骨样组织形成的诱导剂（EC 50 : 100 nM）。
GC15148	Ionomycin calcium salt	56092-82-1	>98.00%
GC15148	Ionomycin calcium salt是一种窄谱抗生素,对革兰氏阳性菌具有活性,由丛生链霉菌(Streptomyces conglobatus)产生。
GC15170	SB 772077B dihydrochloride	607373-46-6	>98.50%
GC15170	A ROCK1 and ROCK2 inhibitor
GC15345	[Ala113]-MBP (104-118)	99026-78-5	-
GC15345	[Ala113]-MBP (104-118) 是一种蛋白激酶 C (PKC) 的非竞争性肽抑制剂，IC50 范围为 28-62 μM。
GC15446	Ionomycin free acid	56092-81-0	{{1-15}>98.00%}
GC15446	Ionomycin free acid 是一种选择性的强效钙离子载体，可作为活性 Ca2+ 载体。
GC15471	PKC β pseudosubstrate	172308-76-8	-
GC15471	Selective cell-permeable peptide inhibitor of protein kinase C
GC15564	Go 6976	136194-77-9	>99.00% / >98.00%
GC15564	Go 6976 是一种有效的蛋白激酶(PKs)抑制剂，对PKC、cGMP依赖性蛋白激酶和肌球蛋白轻链激酶的IC 50 值分别为0.02μM、6.2μM和5.8μM。
GC15567	K02288	1431985-92-0	>98.00%
GC15567	A BMP signaling inhibitor
GC15884	Dasatinib Monohydrate	863127-77-9	-
GC15884	An inhibitor of Abl and Src
GC16289	SAR407899 hydrochloride	923262-96-8	>98.00%
GC16289	A ROCK1 and ROCK2 inhibitor
GC16405	Safingol	15639-50-6	-
GC16405	A dual inhibitor of PKC and SPHK
GC16475	Afuresertib	1047644-62-1	>99.50%
GC16475	A pan-Akt inhibitor
GC16510	ZIP, Biotinylated	-	-
GC16510	ZIP with a biotin moiety covalently attached
GC16539	Butaprost	69685-22-9	>98.00%
GC16539	A selective agonist for the EP 2 receptors
GC16584	TCS 21311	1260181-14-3	>95.00%
GC16584	A JAK3 inhibitor
GC16678	UCN-02	121569-61-7	-
GC16678	A PKC inhibitor