GlpBio

PAI-1

PAI-1(纤溶酶原激活物抑制物1)

Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and functionally serves to suppress tissue and plasma fibrinolysis.

PAI-1 is a member of the serpin family of proteins and exists in multiple conformations of which a minor component, the “active” form, exhibits inhibitory effects against tPA and uPA.

PAI-1 is an endogenous inhibitor of urokinase-type plasminogen activator (uPA), and its expression is regulated by a number of intrinsic factors (e.g., cytokines and growth factors) and extrinsic factors (e.g., cellular stress).

PAI-1 seems to play a pivotal role in tumor growth and may represent a potential therapeutic target for bladder cancer.

PAI-1 相关产品(13)

  • GC12387 structure
    GC12387Tiplaxtinin(PAI-039)
    CAS: 393105-53-8
    纯度: >98.00%

    Tiplaxtinin(PAI-039)是一种口服生物利用的尿激酶型纤溶酶原激活物抑制剂-1（PAI-1）拮抗剂，IC 50 值为2.7μM。

  • GC18173 structure
    GC18173TM5441
    CAS: 1190221-43-2
    纯度: >98.00%

    TM5441是一种具有口服生物利用度的纤溶酶原激活物抑制剂-1（PAI-1）抑制剂，其IC₅₀值介于13.9至51.1μM之间，并能在多种人类癌细胞系中诱导内源性凋亡。

  • GC19358 structure
    GC19358TM5275 sodium
    CAS: 1103926-82-4
    纯度: >98.00%

    A PAI-1 inhibitor

  • GC31889 structure
    GC31889ZK824859
    CAS: 2271122-53-1

    ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79?nM, 1580?nM and 1330?nM for human uPA, tPA, and plasmin, respectively.

  • GC34324 structure
    GC34324ZK824859 hydrochloride
    纯度: >99.00%

    ZK824859hydrochloride是一种口服有效的选择性尿激酶型纤溶酶原激活剂(uPA)抑制剂，用于人uPA，tPA和纤溶酶，IC50分别为79nM，1580nM和1330nM。

  • GC38971 structure
    GC38971Toddalolactone
    CAS: 483-90-9
    纯度: >98.00%

    Toddalolactone, a natural coumarin, inhibits the activity of recombinant human Plasminogen activator inhibitor-1 (PAI-1) in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM.

  • GC61511 structure
    GC61511Angstrom6
    CAS: 220334-14-5
    纯度: >99.00%

    Angstrom6(A6Peptide)是一种来源于单链尿激酶纤溶酶原激活剂(scuPA)的8个氨基酸的肽，可干扰uPA/uPAR级联反应并消除下游效应。Angstrom6与CD44结合，抑制肿瘤细胞的迁移、侵袭和转移，调节CD44介导的细胞信号。

  • GC65281 structure
    GC65281Aleplasinin
    CAS: 481629-87-2
    纯度: >99.00%

    Aleplasinin 是一种口服有效的、可透过血脑屏障的、选择性的 SERPINE1 (PAI-1，纤溶酶原激活物抑制剂 -1) 抑制剂。Aleplasinin 增加淀粉样蛋白 -β (Aβ) 分解代谢，改善淀粉样蛋白相关病理。Aleplasinin 可改善记忆缺陷。Aleplasinin 可用于阿尔茨海默病的研究。

  • GC67781 structure
    GC67781Diaplasinin
    CAS: 481631-45-2
    纯度: >99.00%

    Diaplasinin (PAI-749) 是纤溶酶原激活剂抑制剂-1 (PAI-1) 抑制剂，IC50 为 295 nm。具有抗血栓功效。

  • GC68013 structure
    GC68013CDE-096
    CAS: 1228357-04-7

    CDE-096 是一种有效的 PAI-1 抑制剂。CDE-096 可防止PAI-1 以类似的效力 (分别为 IC50=30 和25 nM) 使 tPA 和 uPA 失活，并对糖基化 PAI-1 以及来源于几种物种的 PAI-1 具有活性 (对小鼠、大鼠和猪 PAI-1 分别为 IC50=19、22 和 18 nM)。

  • GC70534 structure
    GC70534PPACK TFA
    CAS: 157379-44-7
    纯度: >99.00%

    PPACK TFA是一种纤溶酶原激活剂(rt-PA)抑制剂。

  • GC72878 structure
    GC72878UCD38B hydrochloride
    CAS: 1115177-19-9
    纯度: >99.00%

    UCD38B hydrochloride是一种细胞渗透的竞争性酶促uPA抑制剂，IC50值为7 μM。

  • GN10267 structure
    GN10267Loureirin B
    CAS: 119425-90-0
    纯度: >99.00%

    A flavonoid with diverse biological activities