ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79?nM, 1580?nM and 1330?nM for human uPA, tPA, and plasmin, respectively.
ZK824859, a selective and orally bioavailable inhibitor of uPA, lowers clinical scores when dosed in both acute and chronic mouse EAE models.[1]
[1] Imadul Islam, et al. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375.