Sarolaner is an orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs [1].
In vitro sarolaner demonstrated an LC80 of 0.3μg/mL against C. felis and an LC100 of 0.003μg/mL against O. turicata [1].
In vivo efficacy (> 99%) of sarolaner was demonstrated against fleas and ticks for at least one month from a single oral dose of between 1.25 and 5mg/kg in dogs [1]. Sarolaner at an oral dose of 2mg/kg was highly effective in reducing the live mite counts in dogs with a natural infestation of Demodex spp. and an induced infestation of O. cynotis [2]. Oral administration of sarolaner at 2–4mg/kg achieved >95% efficacy against the feline fur mite Lynxacarus radovskyi at Day 30 post-treatment [3].
References:
[1] McTier, Tom L., et al. "Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs." Veterinary Parasitology 222 (2016): 3-11.
[2] Six, Robert H., et al. "Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis." Veterinary Parasitology 222 (2016): 62-66.
[3] Campos, Diefrey R., et al. "Efficacy of oral sarolaner against Lynxacarus radovskyi in naturally infested cats." Veterinary Dermatology 31.5 (2020): 355-e92.
Sarolaner是一种口服的、广谱的异噁唑啉类犬体外寄生虫杀灭剂 [1]。
体外实验中，Sarolaner对跳蚤（Ctenocephalides felis）的LC80为 0.3μg/mL，对软蜱(Ornithodoros turicata)的LC100为 0.003μg/mL [1]。
体内试验中，Sarolaner （1.25 and 5mg/kg）给狗口服，对跳蚤和蜱虫的杀灭效果(> 99%)至少能持续一个月[1]。口服剂量为 2mg/kg 的Sarolaner能有效降低自然感染Demodex spp.和人为感染O. cynotis的犬体内活螨的数量 [2]。给猫单次口服Sarolaner 2-4mg/kg，治疗后 30 天对猫毛螨 Lynxacarus radovskyi 的清除效果达到 95% 以上 [3]。