GlpBio

D-Galactose (D-(+)-Galactose)

目录号: GC30795纯度: >99.00%同义词: D-半乳糖; D-(+)-Galactose

A natural aldohexose

D-Galactose (D-(+)-Galactose)
Cas No.: 59-23-4
规格价格库存数量操作
100mg¥140.00现货
1
500mg¥280.00现货
1
1g¥350.00现货
1
5g¥490.00现货
1
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文献被引

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产品描述 Description

D-Galactose is a natural aldohexose and C-4 epimer of glucose. D-galactose is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. Chronic, systemic exposure to D-galactose accelerates senescence in invertebrates and mammals and has been used as a model for aging.1 In bacteria, D-galactose is imported by a methyl-galactoside transport system to drive chemotaxis.2


D-半乳糖是一种天然的醛糖，也是葡萄糖的C-4异构体。D-半乳糖可以通过酶促反应转化为D-葡萄糖进行代谢或用于多糖的储存。长期、全身性的接触D-半乳糖会加速无脊椎动物和哺乳动物的衰老，因此被用作衰老的模型。[1]在细菌中，D-半乳糖通过甲基半乳糖运输系统进入细胞，驱动趋化。2

1.Cui, X., Zuo, P., Zhang, Q., et al.Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R-α-lipoic acidJ. Neurosci. Res.84(3)647-654(2006) 2.Borrok, M.J., Kiessling, L.L., and Forest, K.T.Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structuresProtein Sci.16(6)1032-1041(2007)

实验参考方法 Experimental Reference Method

Animal experiment:

Rats: D-galactose is dissolved in water for administration at the dose of 100 mg/kg of body weight, and given by oral gavage, once a day, over a period of 1, 2, 4, 6 or 8 weeks. Animals are randomized into two groups: control animals (receiving water by oral gavage) or d-gal animals (receiving D-galactose by oral gavage). The behavioral tests and biochemical analysis are undertaken on the1st, 2nd, 4th, 6th and 8th weeks after the last administration of d-gal[3]. Mice: Male adult C57BL/6 mice are randomly divided into three groups (control, D-galactose, and D-galactose plus α-LA). D-galactose (100 mg/kg) is injected subcutaneously (s.c.) daily into mice for 7 weeks. α-LA (100 mg/kg body weight) is injected peritoneally (i.p.) daily concomitantly for 7 weeks. All control animals are given saline[2].

References:

[1]. Csiszovszki Z, et al. Structure and function of the D-galactose network in enterobacteria. MBio. 2011 Jun 28;2(4):e00053-11.
[2]. Cui X, et al. Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidativedamage in mice: protective effects of R-alpha-lipoic acid. J Neurosci Res. 2006 Aug 15;84(3):647-54.
[3]. Budni J, et al. Oral administration of d-galactose induces cognitive impairments and oxidative damage in rats. Behav Brain Res. 2016 Apr 1;302:35-43.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
59-23-4
同义词
D-半乳糖; D-(+)-Galactose
SMILES
O=C[C@@H]([C@H]([C@H]([C@@H](CO)O)O)O)O
分子式
C6H12O6
分子量
180.16 g/mol
溶解性
Water : ≥ 100 mg/mL (555.06 mM)
保存条件
Store at RT
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol