4’-hydroxyphenyl Carvedilol is a metabolite of carvedilol that is a more potent β-adrenergic receptor antagonist than carvedilol but has weaker vasodilatory activity.1 It is formed through oxidation primarily by the cytochrome P450 (CYP) isoform CYP2D6.2 4’-hydroxyphenyl Carvedilol inhibits the formation of DPPH radicals in a cell-free assay.3
1.Patel, D.P., Sharma, P., Sanyal, M., et al.UPLC-MS/MS assay for the simultaneous quantification of carvedilol and its active metabolite 4'-hydroxyphenyl carvedilol in human plasma to support a bioequivalence study in healthy volunteersBiomed. Chromatogr.27(8)974-986(2013) 2.Oldham, H.G., and Clarke, S.E.In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(–)-carvedilolDrug Metab. Dispos.25(8)970-977(1997) 3.Malig, T.C., Ashkin, M.R., Burman, A.L., et al.Comparison of free-radical inhibiting antioxidant properties of carvedilol and its phenolic metabolitesMedchemcomm.8(3)606-615(2017)