GlpBio

Acetyl-CoA Carboxylase

Acetyl-CoA Carboxylase(乙酰辅酶A羧化酶)

Acetyl-CoA carboxylase (ACC) is a biotin carboxylase that catalyzes the ATP-dependent condensation of acetyl-CoA and carbonate to form malonyl-CoA. The malonyl-CoA produced by ACC serves two major physiologic functions. It is an essential and rate-limiting substrate for de novo lipogenesis (DNL), and it acts as an allosteric inhibitor of the enzyme carnitine-palmitoyl transferase I (CPT-1). Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential for the treatment of type 2 diabetes mellitus (T2DM), hepatic steatosis, and cancer.

Acetyl-CoA carboxylase (ACC) in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks CPT-1 function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).

Acetyl-CoA Carboxylase 相关产品(14)

  • GC13434 structure
    GC13434CP-640186
    CAS: 591778-68-6
    纯度: >98.50%

    An ACC inhibitor

  • GC19261 structure
    GC19261ND-630 (Firsocostat)
    CAS: 1434635-54-7
    纯度: >98.00%

    ND-630 (Firsocostat)是一种乙酰辅酶A羧化酶(ACC)抑制剂，可抑制ACC1（IC 50 =2.1nM）和ACC2（IC 50 =6.1nM）的活性。

  • GC19284 structure
    GC19284PF-05175157
    CAS: 1301214-47-0
    纯度: >98.00%

    An inhibitor of ACC1 and 2

  • GC25726 structure
    GC25726PF-05221304
    CAS: 1370448-25-1

    PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL).

  • GC30047 structure
    GC30047Olumacostat glasaretil
    CAS: 1261491-89-7
    纯度: >98.50%

    Olumacostatglasaretil是乙酰辅酶A羧化酶(ACC)的小分子抑制剂。

  • GC31344 structure
    GC31344MK-4074
    CAS: 1039758-22-9
    纯度: >99.50%

    MK-4074是乙酰辅酶A羧化酶(acetyl-CoAcarboxylase)的肝特异性抑制剂，IC50值约为3nM。

  • GC32706 structure
    GC32706ND-646
    CAS: 1434639-57-2
    纯度: >98.50%

    An ACC inhibitor

  • GC32715 structure
    GC32715TOFA (RMI14514)
    CAS: 54857-86-2
    纯度: >99.50% / >98.00%

    TOFA (RMI14514)是乙酰辅酶A羧化酶-α (ACCA)的变构抑制剂。

  • GC35740 structure
    GC35740CP-640186 hydrochloride
    CAS: 591778-70-0
    纯度: >99.50%

    An ACC inhibitor

  • GC61758 structure
    GC61758Fluazifop-P-butyl
    CAS: 79241-46-6
    纯度: >98.50%

    Fluazifop-P-butyl是一种来自芳基苯氧基丙酸酯的杀草剂，是一种乙酰辅酶A羧化酶(ACCase)抑制剂。

  • GC64300 structure
    GC64300Haloxyfop
    CAS: 69806-34-4

    Haloxyfop 是一种芳氯氧苯氧丙酸除草剂 (herbicide)，广泛应用于阔叶作物的野草。Haloxyfop 对玉米幼苗叶绿体中乙酰辅酶 A 羧化酶 (EC 6.4.1.2) 的抑制作的 IC50 为 0.5 μM，而对豌豆中该酶无影响。

  • GC68587 structure
    GC68587A-908292
    CAS: 903886-95-3
    纯度: >99.00%

    A-908292 是一种有效和选择性的乙酰辅酶 A 羧化酶 2 (ACC2) 抑制剂，抑制 hACC2 的 IC50 值为 23 nM。A-908292 可用于脂肪酸代谢的研究。

  • GC68603 structure
    GC68603Acetyl-CoA Carboxylase-IN-1
    CAS: 179343-23-8
    纯度: >99.00%

    Acetyl-CoA Carboxylase-IN-1 是一种有效的乙酰辅酶 A 羧化酶 (ACC) 抑制剂，IC50 值为 <5 nM。 Acetyl-CoA Carboxylase-IN-1 具有抗菌活性。

  • GC70436 structure
    GC70436Propaquizafop
    CAS: 111479-05-1
    纯度: >98.00%

    Propaquizafop是一种苯氧异丙酸除草剂和乙酰辅酶a羧化酶抑制剂。