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Home >> Signaling Pathways >> Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

  1. Cat.No. 产品名称 Information
  2. GC74657 1-Octanol-d17

    Octanol-d17

     1-Octanol-d17是氘标记的1-辛醇。
  3. GC40183 1-Oleoyl Glycerol

    甘油单油酸酯

     A monoacylglycerol
  4. GC92061 1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC

    1-Hexadecanoyl-2-13(S)-HODE-sn-glycero-3-Phosphocholine; 13(S)-Hydroxyoctadecadienoic Acid-PLPC; 1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-Phosphocholine; 1-Palmitoyl-2-(13-hydroxy-cis-9,trans-11-octadecadienoyl)-L-3-phosphatidylcholine

     1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC是分别在sn-1和sn-2位置含有棕榈酸和13S-HODE的氧化磷脂。
  5. GC46488 1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-PC

    1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-Phosphocholine, 1-Palmitoyl-2-Docosahexaenoyl-sn-glycero-3-Phosphatidylcholine, PC(16:0/22:6), 16:0/22:6-PC, PDPC

     A phospholipid
  6. GC68501 1-Palmitoyl-2-oleoyl-sn-glycerol 1-Palmitoyl-2-oleoyl-sn-glycerol 是一种内源性代谢物，也是藻殖段诱导因子 (HIF)-1 中主要的二酰基甘油。
  7. GC49366 1-Salicylate Glucuronide

    Salicyl Phenolic Glucuronide, Salicylic Acid Phenolic Glucuronide

     A metabolite of salicylic acid and aspirin
  8. GC42039 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC

    15(S)-HETE-SAPC, 15(S)-Hydroxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylcholine

     An oxidized phospholipid
  9. GC42040 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE

    15(S)-HETE-SAPE, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine

    An oxidized phospholipid
  10. GC49730 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11

    15(S)-HETE-SAPE-d11, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE-d11, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine-d11

     An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE
  11. GC42041 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC

    15(S)-HpETE-SAPC, 15(S)-Hydroperoxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Phosphatidylcholine

    An oxidized phospholipid
  12. GC42042 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE

    1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine, 15(S)-HpETE-SAPE, 15(S)-hydroperoxyeicostetraenoic acid-SAPE

    An oxidized phospholipid
  13. GC11139 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PC

    L-α-磷脂酰胆碱-β-花生四烯酰-γ-硬脂酰,SAPC

     A phospholipid
  14. GC68502 1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine

    1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine 可以选择作为用于研究氧化磷脂酰胆碱分子种类的挥发性化合物的模型。这个方法应用于实际食品样品，即大豆卵磷脂。
  15. GC40971 10(S),17(S)-DiHDHA

    10(S),17(S)-DiHDoHE; PDX

     A DHA derivative with anti-inflammatory and anti-platelet activity
  16. GC49820 10,11-dihydro-10,11-dihydroxy Carbamazepine

    奥卡西平杂质

     A metabolite of carbamazepine and oxcarbazepine
  17. GC66057 10,11-Dihydrocarbamazepine

    10,11-二氢卡马西平

     10,11-二氢卡马西平（10,11-Dihydrocarbamazepine）用作液相色谱法同时测定血浆中卡马西平及其活性代谢物的内标。可用于化学发光法测定卡马西平的含量。
  18. GC38881 10,12-Tricosadiynoic acid

    10,12-二十三联炔酸

     10,12-Tricosadiynoic acid 是一种高特异性，选择性，高亲和力且具有口服活性的酰基辅酶 A 氧化酶-1 (ACOX1) 抑制剂。10,12-Tricosadiynoic acid 可通过改善线粒体脂质和 ROS 代谢来治疗高脂饮食或肥胖引起的代谢性疾病。
  19. GC49118 10-hydroxy Warfarin

    10-羟基华法林(非对映体的混合物)

    A metabolite of (R)-warfarin
  20. GC33800 10Z-Nonadecenoic acid

    十九碳烯酸(顺-10)

     10Z-Nonadecenoic acid 是一种具有抗肿瘤活性的长链脂肪酸。也可以抑制 p53 活性
  21. GC40368 11(R)-HEPE Produced by the oxidation of EPA by 11(R)-LO
  22. GC40445 11(R)-HETE

    11(R)-Hydroxyeicosatetraenoic Acid

     An oxylipin
  23. GC39223 11-Beta-hydroxyandrostenedione

    4-雄烯-11β-醇-3,17-二酮,4-Androsten-11β-ol-3,17-dione

     11β-Hydroxyandrostenedione是一种内源性、天然存在的?类固醇和雄激素原，主要（如果不是完全）在肾上腺中产生。它与肾上腺产生的肾上腺素(11-ketoandrostenedione; 11-KA4)、11-ketotestosterone?(11-KT) 和11-ketodihydrotestosterone?(11-KDHT)密切相关。可用作指导肾上腺静脉取样中原发性醛固酮增多症亚型的生物标志物，其中从两个肾上腺采集血样以比较每个腺体产生的激素量。
  24. GC40730 11-cis Vaccenyl Acetate Male mating pheromone of D. melanogaster
  25. GC40394 11-deoxy Corticosterone

    去氧皮质酮

     An endogenous mineralocorticoid
  26. GC10821 11-keto-β-Boswellic Acid

    11-酮基-BETA-乳香酸,11-oxo-β-Boswellic acid,KBA

     A 5-LO inhibitor
  27. GC61538 11-Oxo etiocholanolone

    11-酮本胆烷醇酮,11-Ketoetiocholanolone

     11-oxo Etiocholanolone 是皮质醇和 11-酮睾酮的代谢产物。由皮质醇经可的松和四氢可的酮中间体形成，由11-酮睾酮经5β-11-酮二氢睾酮和3α-11-酮基胆二醇中间体形成.?妊娠期间 11-氧代胆烷醇酮的尿液水平升高，并且在子宫平滑肌瘤患者中升高。11-氧代胆烷醇酮的粪便水平已被用作家畜和散养反刍动物压力的标志物。
  28. GC41144 11-trans Leukotriene C4

    11trans LTC4

     A C-11 double bond isomer of LTC4
  29. GC41147 11-trans Leukotriene D4

    11trans LTD4

     A C-11 double bond isomer of LTD4
  30. GC41149 11-trans Leukotriene E4

    11trans LTE4

     The C-11 double bond isomer of LTE4
  31. GC63796 116-9e

    MAL2-11B

     116-9e 是 Hsp40-Hsp70 结合的阻断剂，从而抑制 Hsp70-Hsp40 的伴侣活性。Hsp40 家族的辅助伴侣通过一个保守的 J 结构域与 Hsp70 结合。116-9e 通过阻止 Hsp70-Hsp40 复合物组装来抑制伴侣功能。
  32. GC34016 11beta-Hydroxyprogesterone (11β-Hydroxyprogesterone)

    11β-羟孕酮; 11β-Hydroxyprogesterone

     A metabolite of progesterone
  33. GC40447 12(R)-HETE

    12(R)-Hydroxyeicosatetraenoic Acid

     An active metabolite of arachidonic acid
  34. GC40371 12(S)-HEPE An anti-inflammatory monohydroxy fatty acid derived from EPA
  35. GC40448 12(S)-HETE

    12(S)-Hydroxyeicosatetraenoic Acid

     The predominant lipoxygenase product of mammalian platelets
  36. GC40349 12(S)-HETE-19,20-alkyne

    Click Tag 12(S)-HETE-19,20-alkyne, Click Tag 12(S)-Hydroxyeicosatetraenoic Acid-19,20-alkyne

     A probe for 12(S)-HETE activity
  37. GC41882 12(S)-HETrE An inhibitor of platelet activation
  38. GC41095 12(S)-HpEPE A 12-LO product derived from EPA
  39. GC41122 12(S)-HpETE

    A 12-LO metabolite of arachidonic acid
  40. GC41123 12-epi Leukotriene B4

    12epi LTB4

     LTB4 isomer with weak agonist activity at BLT1 and BLT2 receptors
  41. GC46416 12-epi Leukotriene B4-d4

    12epi LTB4d4

     A neuropeptide with diverse biological activities
  42. GC45962 12-hydroxy Lauric Acid

    端羟基12酸

     A hydroxylated fatty acid
  43. GC60443 12-Ketodeoxycholic acid

    胆酸杂质9

     12-Ketodeoxycholic acid 是一种胆汁酸，来自肾脏的代谢产物。12-酮脱氧胆酸可作为肾损伤证据的可检测标志物
  44. GC41096 12-oxo Leukotriene B4

    12keto LTB4, 12oxo LTB4

     A natural metabolite of LTB4
  45. GC46418 12-oxo-13-HOME An oxylipin
  46. GC90652 12-oxo-9(Z)-Dodecenoic Acid

    12-keto-9Z-Dodecenoic Acid, 12-oxo-9-cis-Dodecenoic Acid

    亚油酸和亚麻酸的代谢产物。
  47. GC40372 12-OxoETE

    12-KETE

     A 12-oxo derivative of arachidonic acid
  48. GC19462 13(R)-HODE An enantiomer of 13(S)-HODE
  49. GC19463 13(S)-HODE

    13(S)-HODE

    Product of 15-LO metabolism of linoleic acid
  50. GC41220 13(S)-HODE methyl ester Hydroxy fatty acid methyl ester
  51. GC41896 13(S)-HODE-biotin A biotinylated PUFA

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