Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GA23863Z-Leu-Val-Gly-diazomethylketoneCAS: 119670-30-3纯度: >98.00%
Z-Leu-Val-Gly-diazomethylketone 是一种可渗透细胞且不可逆的半胱氨酸蛋白酶抑制剂。
- GC10007LX1606 Hippurate (Telotristat etiprate)CAS: 1137608-69-5纯度: >99.50%
Telotristat etiprate 是一种乙酯前药，可在体内和体外水解为其活性部分 LP-778902。
- GC10018Talabostat mesylateCAS: 150080-09-4纯度: >99.00%
Talabostat (PT100)是一种口服活性和非选择性二肽基肽酶IV（DPP-IV）抑制剂(IC50 < 4 nM; Ki = 0.18 nM)和成纤维细胞活化蛋白(FAP)的第一种临床抑制剂(IC50 = 560 nM)，抑制DPP 8/9(IC50= 4/11 nM; Ki = 1.5/0.76 nM)，静止细胞脯氨酸二肽酶(QPP)( IC50= 310 nM)，DPP 2和其他一些DASH家族酶。
- GC10140Thrombin Receptor Agonist PeptideCAS: 137339-65-2
A peptide agonist of the α-thrombin receptor
- GC10156o-PhenanthrolineCAS: 66-71-7纯度: >98.00% / >99.00%
o-Phenanthroline是一种常用的有机螯合剂和配体，能与多种金属离子（如Fe²⁺、Zn²⁺）形成稳定的配合物。
- GC10298Sitagliptin phosphate monohydrateCAS: 654671-77-9纯度: >99.50%
Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) 是一种有效的 DPP4 抑制剂，在 Caco-2 细胞提取物中的 IC50 为 19 nM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GA23610 | Thymopentin | 69558-55-0 | >98.00% | |
A pentapeptide fragment of thymopoietin | ||||
| GA23863 | Z-Leu-Val-Gly-diazomethylketone | 119670-30-3 | >98.00% | |
Z-Leu-Val-Gly-diazomethylketone 是一种可渗透细胞且不可逆的半胱氨酸蛋白酶抑制剂。 | ||||
| GC10007 | LX1606 Hippurate (Telotristat etiprate) | 1137608-69-5 | >99.50% | |
Telotristat etiprate 是一种乙酯前药，可在体内和体外水解为其活性部分 LP-778902。 | ||||
| GC10016 | NCT-501 | 1802088-50-1 | >99.50% | |
A reversible inhibitor of ALDH1A1 | ||||
| GC10018 | Talabostat mesylate | 150080-09-4 | >99.00% | |
Talabostat (PT100)是一种口服活性和非选择性二肽基肽酶IV（DPP-IV）抑制剂(IC50 < 4 nM; Ki = 0.18 nM)和成纤维细胞活化蛋白(FAP)的第一种临床抑制剂(IC50 = 560 nM)，抑制DPP 8/9(IC50= 4/11 nM; Ki = 1.5/0.76 nM)，静止细胞脯氨酸二肽酶(QPP)( IC50= 310 nM)，DPP 2和其他一些DASH家族酶。 | ||||
| GC10027 | Leupeptin, Microbial | 103476-89-7 | >98.00% | |
Leupeptin, Microbial 是一种广谱丝氨酸和半胱氨酸蛋白酶抑制剂。 | ||||
| GC10042 | Vitamin E | 59-02-9 | >99.00% / >98.00% | |
脂溶性维生素 | ||||
| GC10067 | 6-Hydroxynicotinic acid | 5006-66-6 | >98.00% | |
6-羟基烟酸是一种内源性代谢物。 | ||||
| GC10084 | Pyridoxal 5 phosphate | 54-47-7 | >98.00% / >99.50% | |
An enzyme cofactor | ||||
| GC10091 | Nateglinide | 105816-04-4 | >99.50% | |
A hypoglycemic agent | ||||
| GC10123 | O-Phospho-L-serine | 407-41-0 | >98.00% | |
A glutamate receptor agonist | ||||
| GC10134 | Ginkgolic Acid C15:1 | 22910-60-7 | >98.00% | |
An inhibitor of SUMOylation | ||||
| GC10140 | Thrombin Receptor Agonist Peptide | 137339-65-2 | - | |
A peptide agonist of the α-thrombin receptor | ||||
| GC10142 | Enalapril Maleate | 76095-16-4 | >99.50% | |
An ACE inhibitor | ||||
| GC10146 | AHU-377(Sacubitril) | 149709-62-6 | >99.00% | |
A prodrug form of LBQ657 | ||||
| GC10149 | cis-ACCP | 777075-44-2 | - | |
A matrix metalloproteinase inhibitor | ||||
| GC10156 | o-Phenanthroline | 66-71-7 | >98.00% / >99.00% | |
o-Phenanthroline是一种常用的有机螯合剂和配体，能与多种金属离子（如Fe²⁺、Zn²⁺）形成稳定的配合物。 | ||||
| GC10171 | Puromycin aminonucleoside | 58-60-6 | >98.00% | |
A glomerular epithelial cell toxin | ||||
| GC10199 | Hypoxanthine | 68-94-0 | >99.50% | |
An endogenous purine derivative | ||||
| GC10265 | Manumycin A | 52665-74-4 | >98.00% | |
A farnesyltransferase inhibitor with antitumor activity | ||||
| GC10278 | Sucralose | 56038-13-2 | >98.00% | |
A synthetic disaccharide and non-caloric sweetener | ||||
| GC10292 | i-Inositol | 87-89-8 | >99.00% | |
i-Inositol是一种参与胰岛素信号转导、细胞骨架转导等一系列生物过程的糖醇。 | ||||
| GC10298 | Sitagliptin phosphate monohydrate | 654671-77-9 | >99.50% | |
Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) 是一种有效的 DPP4 抑制剂，在 Caco-2 细胞提取物中的 IC50 为 19 nM。 | ||||
| GC10312 | Trehalose | 99-20-7 | >98.00% | |
A natural non-reducing disaccharide | ||||