Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC46420 13(S)-HODE-d4 An internal standard for the quantification of 13-HODE
GC41897 13(S)-HOTrE A 15-LO product derived from GLA
GC41898 13(S)-HOTrE(γ) A 15-LO product derived from GLA
GC19474 13(S)-HpODE Stimulates EGF-dependent mitogenesis and tyrosine phosphorylation
GC41899 13(S)-HpOTrE
A product of soybean LO-2 metabolism of α-linolenic acid
GC41900 13(S)-HpOTrE(γ) Produced by the action of soybean LO-1 on γ-linolenic acid
GC62758 13-cis-Vitamin A palmitate

13-CIS维生素A棕榈酸酯,13-cis-Retinyl palmitate
13 -cis-?retinyl hexadecanoate是十六烷酸的羧基与13-cis-retinol的羟基缩合而成的视黄酯,是由维生素A棕榈酸酯在玉米片中形成的13顺式异构体。13-顺式维生素 A 棕榈酸酯的生物活性是全反式维生素 A 棕榈酸酯的 75%，是维生素 A 中最具生物活性的形式。
GC41911 13-epi-12-oxo Phytodienoic Acid

13-EPI-12-氧代植物二烯酸
A lipoxygenase metabolite of α-linolenic acid
GC46436 13-OxoODE-d3

13KODEd3
A neuropeptide with diverse biological activities
GC49759 13C17-Mycophenolic Acid

霉酚酸-(全碳-13)
An internal standard for the quantification of mycophenolic acid
GC41206 14(S)-HDHA

14(S)-HDoHE
An anti-inflammatory lipid produced by macrophages
GC41100 14,15-dehydro Leukotriene B4

14,15dehydro LTB4
A LTB₄ receptor antagonist
GC41145 14,15-Leukotriene C4

Eoxin C4, EXC4, 14,15LTC4
A pro-inflammatory arachidonic acid metabolite
GC41148 14,15-Leukotriene D4

Eoxin D4, EXD4, 14,15-LTD4
A pro-inflammatory arachidonic acid metabolite
GC41150 14,15-Leukotriene E4

Eoxin E4, EXE4, 14,15LTE4
A metabolite of 14,15-LTC₄ with pro-inflammatory activity
GC41415 15(R)-Lipoxin A4

AT-Lipoxin A4
An aspirin-triggered lipoxin
GC40427 15(S)-HEDE Isolated by the chromatographic resolution of (±)15-HEDE
GC40373 15(S)-HEPE

15S-hydroxy-Eicosapentaenoic Acid
A monohydroxy fatty acid derived from EPA
GC46441 15(S)-HEPE-d5

15S-Hydroxyeicosapentaenoic Acid-d5
A neuropeptide with diverse biological activities
GC40451 15(S)-HETE

15(S)-Hydroxyeicosatetraenoic Acid
An active metabolite of arachidonic acid
GC41925 15(S)-HETE Ethanolamide

15(S)-HAEA, 15(S)-Hydroxyeicosatetraenoic Acid Ethanolamide
A CB₁ receptor ligand and FAAH inhibitor
GC40839 15(S)-HETE methyl ester

15(S)-Hydroxyeicosatetraenoic Acid methyl ester
A synthetic derivative of 15(S)-HETE
GC41926 15(S)-HETE-biotin

15(S)-Hydroxyeicosatetraenoic Acid-biotin
Used to detect 15(S)-HETE binding proteins and/or receptors
GC46442 15(S)-HETE-d8

15(S)-Hydroxyeicosatetraenoic Acid-d8
An internal standard for the quantification of 15(S)-HETE
GC49894 15(S)-HETE-d8 ethyl ester

15(S)-Hydroxyeicosatetraenoic Acid-d8 ethyl ester
An internal standard for the quantification of 15(S)-HETE ethyl ester
GC41927 15(S)-HETrE A 5-LO inhibitor
GC41403 15(S)-HpEDE A 15-LO product derived from eicosadienoic acid
GC41101 15(S)-HpEPE Produced by the action of 15-lipoxygenase on EPA
GC41124 15(S)-HpETE

15-羟基二十碳-5Z,8Z,11Z,13E-四烯酸
A product of 15-LO metabolism of arachidonic acid
GC11988 15-acetoxy Scirpenol

15-乙酰蛇形菌素
A trichothecene mycotoxin
GC19442 15-Acetyldeoxy Nivalenol

15-O-乙酰脱氧瓜萎镰菌醇
A natural mycotoxin
GC41937 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide

15-KETO-比马前列素
A potential metabolite of Bimatoprost
GC41938 15-Lipoxygenase Inhibitor 1

15LO Inhibitor 1
An inhibitor of 15-LO
GC41940 15-OxoEDE

15KEDE
A PUFA produced by oxidation of 15-HEDE
GC40376 15-OxoETE

15KETE
An oxylipin produced by oxidation of the 15-hydroxyl of 15-HETE
GC41309 16α-hydroxy Prednisolone

16alpha-羟基泼尼松龙,OH-PRED
A stereoselective metabolite of 22(R)-budesonide
GC35058 16-Dehydroprogesterone

16-去氢黄体酮
16-Dehydroprogesterone is a chemical derived from a progesterone.
GC46451 16F16 A PDI inhibitor
GC45909 17α-hydroxy Pregnenolone

17α-羟基妊娠烯醇酮,NSC 63853
A metabolite of pregnenolone
GC71338 17β-HSD10-IN-1 17β-HSD10-IN-1（化合物9）是一种具有血脑通透性的17β-羟基类固醇脱氢酶10型（17β-HSD10）的口服活性抑制剂。
GC41300 17β-hydroxy Exemestane

亚甲基宝丹酮
An active metabolite of exemestane
GC46471 17β-hydroxy Exemestane-d3 A neuropeptide with diverse biological activities
GC41951 17(R)-Resolvin D1

Aspirin-triggered Resolvin D1
An aspirin-triggered epimer of RvD1
GC41227 17(R)-Resolvin D1 methyl ester

AspirintriggeredResolvin D1 methyl ester, ATRvD1 methyl ester, 17epiResolvin D1 methyl ester, 17(R)RvD1 methyl ester
Methyl ester of an aspirin-triggered resolvin
GC46457 17(R)-Resolvin D1-d5

Aspirin-triggered Resolvin D1-d5, 17-epi-Resolvin D1-d5, AT-RvD1-d5, 17(R)-RvD1-d5
A neuropeptide with diverse biological activities
GC41952 17(R)-Resolvin D4

4(S),5(R),17(R)-trihydroxy-DHA, 17(R)-RvD4
An aspirin-triggered epimer of RvD4
GC41208 17(S)-HDHA

17(S)hydroxy Docosahexaenoic Acid, 17(S)HDoHE
An oxidation product of DHA
GC46048 17(S)-HDHA-d5

17(S)-Hydroxy docosahexaenoic acid-d5, 17(S)-HDoHE-d5
A neuropeptide with diverse biological activities
GC49356 17(S)-HDoTE

17(S)-HDTA, 17(S)-hydroxy Docosatetraenoic Acid
A metabolite of adrenic acid
GC40975 17(S)-HpDHA

17(S)hydroperoxy Docosahexaenoic Acid, 17(S)HpDoHE
A mono-oxygenation product of DHA