GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC10318 structure
    GC10318Hexa-D-arginine
    CAS: 673202-67-0
    纯度: >99.50%

    A furin inhibitor

  • GC10330 structure
    GC10330Lonafarnib
    CAS: 193275-84-2
    纯度: >98.50%

    A farnesyltransferase inhibitor with antitumor activity

  • GC10342 structure
    GC10342Calpeptin
    CAS: 117591-20-5
    纯度: >98.00%

    Calpeptin是一种可逆且可穿透细胞的半胱氨酸组织蛋白酶抑制剂。Calpeptin对钙蛋白酶I和II（猪源）、木瓜蛋白酶以及血小板钙蛋白酶I的ID 50 值分别为52nM, 34nM, 138nM和20nM。Calpeptin可减轻肌肉细胞中的凋亡和继发性炎症变化。

  • GC10353 structure
    GC10353L-homocystine
    CAS: 626-72-2
    纯度: >98.00%

    L-同型半胱氨酸是 L-同型半胱氨酸的氧化成员。

  • GC10396 structure
    GC10396S-Adenosylhomocysteine
    CAS: 979-92-0
    纯度: >98.00%

    S-腺苷同型半胱氨酸 (SAH) （S-Adenosylhomocysteine）是一种氨基酸衍生物，是蛋氨酸代谢 中的关键中间代谢产物。

  • GC10398 structure
    GC10398Heparin sodium
    CAS: 9041-08-1
    纯度: >98.00%

    肝素钠作为抗凝剂，属于一类葡聚糖，可与多种蛋白质相互作用，产生多种生物活性。

  • GC10408 structure
    GC104082-D08
    CAS: 144707-18-6
    纯度: >98.00%

    2-D08是一种合成黄酮和具有细胞通透性的小泛素样修饰蛋白（SUMO）抑制剂，也能抑制Axl靶点，IC 50 为0.49nM。

  • GC10451 structure
    GC10451U-73122
    CAS: 112648-68-7
    纯度: >98.00%

    U-73122是有效的、选择性的磷脂酶C（PLC）抑制剂，IC 50 值约为1-2.1μM，也可抑制5-脂氧合酶（5-LO）。

  • GC10456 structure
    GC10456Fucosterol
    CAS: 17605-67-3
    纯度: >98.00%

    A natural phytosterol with diverse biological activities

  • GC10470 structure
    GC10470Nutlin-3a chiral
    CAS: 675576-98-4
    纯度: >98.00%

    Nutlin-3a 手性是 Nutlin-3 的活性异构体，是鼠类双微体 2 (MDM2) 拮抗剂，IC50 值为 0.09μM。

  • GC10477 structure
    GC10477PMSF
    CAS: 329-98-6
    纯度: >98.00% / >99.00%

    PMSF (苯甲基磺酰氟)是一种不可逆的丝氨酸蛋白酶抑制剂，常在细胞或组织裂解之前加入裂解液中以预防蛋白的降解。

  • GC10481 structure
    GC10481TRC 051384
    CAS: 867164-40-7
    纯度: >98.00%

    TRC 051384 是一种热休克蛋白 70 (HSP70) 诱导剂。

  • GC10485 structure
    GC10485Mutant IDH1-IN-1
    CAS: 1355326-21-4
    纯度: >99.50%

    An inhibitor of mutant IDH1

  • GC10501 structure
    GC10501VER-50589
    CAS: 747413-08-7
    纯度: >99.50%

    Inhibitor of Hsp90

  • GC10531 structure
    GC10531AGI-5198
    CAS: 1355326-35-0
    纯度: >98.00%

    A potent, selective inhibitor of IDH1 mutations

  • GC10533 structure
    GC105337,8-dihydro-L-Biopterin
    CAS: 6779-87-9

    A precursor in the synthesis of BH 4

  • GC10559 structure
    GC10559Erythrodiol
    CAS: 545-48-2

    A triterpene with diverse biological activities

  • GC10572 structure
    GC10572Equisetin
    CAS: 57749-43-6

    An HIV-1 integrase inhibitor

  • GC10576 structure
    GC10576Imeglimin
    CAS: 775351-65-0

    Imeglimin (EMD 387008) 是一种口服降糖剂。

  • GC10577 structure
    GC10577trans-Aconitic acid
    CAS: 4023-65-8
    纯度: >98.00%

    反式乌头酸存在于正常人的尿液中，并且有人建议在雷氏综合征和有机酸尿症中存在大量的乌头酸。

  • GC10582 structure
    GC10582Betacarotene
    CAS: 7235-40-7
    纯度: >98.00%

    Antioxidant, precursor of vitamin A

  • GC10613 structure
    GC10613Nafamostat Mesylate(FUT-175)
    CAS: 82956-11-4
    纯度: >98.00%

    Nafamostat Mesylate(FUT-175)是一种合成的丝氨酸蛋白酶抑制剂。

  • GC10631 structure
    GC10631Melibiose
    CAS: 585-99-9
    纯度: >99.00%

    蜜二糖是一种二糖，由一个半乳糖和一个葡萄糖部分组成的 α (1-6) 糖苷键。

  • GC10661 structure
    GC10661Destruxin B
    CAS: 2503-26-6

    An insecticidal mycotoxin