L-homocystine

目录号: GC10353纯度: >98.00%同义词: L-高胱氨酸

L-同型半胱氨酸是 L-同型半胱氨酸的氧化成员。

Cas No.: 626-72-2

规格	价格	库存	数量
25mg	¥116.00	现货	1
50mg	¥156.00	现货	1
100mg	¥210.00	现货	1
500mg	¥525.00	现货	1
1g	¥781.00	现货	1

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618, 1017–1023 (2023)
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610, 366–372 (2022)
Cell
187(9):2288-2304 (2024)
Cell
183(7):1867-1883 (2020)
Science
388(6745) (2025)
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387(6739) (2025)
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387(6734) (2025)
Cell Research
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产品描述 Description

L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.

A single or multiple doses of L-Homocystine administered to mice during organogenesis can aggravate the developmental disturbances caused by a single dose of VPA administered on GD 8. Whereas, VPA lowers significantly plasma FA and vitamin B12 concentrations, it has no direct impact on the homocysteine concentrations. Therefore, it is proposed that high levels of homocysteine disturb the FA, vitamin B12, and possibly methionine metabolism thus providing a favorable situation for VPA to interfere with the development of susceptible embryos[1].

References:
[1]. Padmanabhan R, et al. Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos. Eur J Nutr. 2006 Sep;45(6):311-9

实验参考方法 Experimental Reference Method

Animal experiment:

Mice[1]Groups of mice are first injected on GD 8 with a single dose of 75 mg/kg of L-Homocystine or an equal volume of saline. One half of the L-Homocystine-treated animals then receive a single dose of 600 mg/kg of VPA ((H-HoCys-OH)2+VPA group), while the other half are injected with a proportionate volume of saline (L-Homocystine+saline group). In the other experiment, mice are treated with a daily dose of 75 mg/kg of L-Homocystine or a proportionate volume of saline starting from GD 5 and continue through GD 10. One half of the L-Homocystine-treated animals also have a single exposure to 600 mg/kg of VPA (L-Homocystine+VPA group) or a proportionate volume of saline (L-Homocystine+saline group) on GD 8. The total volume of fluid injected corresponded to the body weight and does not exceed 0.45 mL[1].

References:

[1]. Padmanabhan R, et al. Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos. Eur J Nutr. 2006 Sep;45(6):311-9

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号

626-72-2

同义词

L-高胱氨酸

化学名

4,4'-disulfanediylbis(2-aminobutanoic acid)

SMILES

NC(C(O)=O)CCSSCCC(N)C(O)=O

分子式

C₈H₁₆N₂O₄S

分子量

268.35 g/mol

溶解性

<2.68mg/mL in DMSO, Limited solubility in Water

保存条件

Store at -20°C

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。

Shipping Condition

评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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