Prostaglandin A2-d4 (PGA2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGA2 by GC- or LC- mass spectrometry. PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. It has low biological potency in most bioassays, but does show some antiviral/antitumor activity.1 At a 25 µM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase.2 It has also been shown to act as a vasodilator with natriuretic properties.3
1.Fukushima, M., Kato, T., Narumiya, S., et al.Prostaglandin A and J: Antitumor and antiviral prostaglandinsAdv. Prostaglandin Thromboxane Leukot. Res.19415-418(1989)
2.Hitomi, M., Shu, J., Strom, D., et al.Prostaglandin A2 blocks the activation of G1 phase cyclin-dependent kinase without altering mitogen-activated protein kinase stimulationJ. Biol. Chem.271(16)9376-9383(1996)
3.Frolich, J.C., Sweetman, B.J., Carr, K., et al.Assessment of the levels of PGA2 in human plasma by gas chromatography-mass spectrometryProstaglandins10(1)185-195(1975)
