L,L-Dityrosine is an amino acid conjugate containing two L-tyrosine molecules. L-Tyrosine residues in fibrinogen proteins can form L,L-dityrosine cross-links between fibrinogen proteins in the presence of hematin and plasma-generated hydrogen peroxide under non-thermal plasma exposure.1 L-Tyrosine residues in human, but not mouse, amylin peptides can form L,L-dityrosine cross-links between amylin peptides in the presence of copper (II) ions and hydrogen peroxide.2
1.Ke, Z., and Huang, Q.Haem-assisted dityrosine-cross-linking of fibrinogen under non-thermal plasma exposure: One important mechanism of facilitated blood coagulationSci. Rep.626982(2016) 2.Dong, X., Svantesson, T., Sholts, S.B., et al.Copper ions induce dityrosine-linked dimers in human but not in murine islet amyloid polypeptide (IAPP/amylin)Biochem. Biophys. Res. Commun.510(4)520-524(2019)