Veratrosine is a steroidal alkaloid that has been found in Veratrum and has diverse biological activities.1,2 It inhibits hedgehog (Hh) signaling in a reporter assay using NIH3T3 cells when used at a concentration of 8 ?M.1 Veratrosine (1 mg/ml) inhibits aggregation of isolated rabbit platelets induced by arachidonic acid . It induces DNA damage in the cerebellum and cerebral cortex in mice when administered at doses of 0.25 and 2.5 ?mol/kg.2 Veratrosine (1.5 and 4.5 ?mol/kg) decreases angiotensin II-induced increases in systolic blood pressure in mice.
1.Tang, J., Li, H.L., Shen, Y.H., et al.Antitumor and antiplatelet activity of alkaloids from Veratrum dahuricumPhytother. Res.24(6)821-826(2010) 2.Cong, Y., Wu, Y., Shen, S., et al.A structure-activity relationship between the Veratrum alkaloids on the antihypertension and DNA damage activity in miceChem. Biodivers.17(2)e1900473(2020)