1-Cinnamoylpyrrolidine is an amide that has been found in P. taiwanense and has antiplatelet and DNA-cleaving activities.1,2 It inhibits arachidonic acid- or collagen-induced aggregation of isolated washed rabbit platelets (IC50s = 30.5 and 37.3 ?M, respectively).1 1-Cinnamoylpyrrolidine (250 ?M) cleaves DNA in a cell-free DNA strand scission assay in the presence, but not absence, of copper ions.2
1.Chen, I.-S., Chen, Y.-C., and Liao, C.-H.Amides with anti-platelet aggregation activity from Piper taiwanenseFitoterapia78(6)414-419(2007) 2.Ma, J., Jones, S.H., and Hecht, S.M.Phenolic acid amides: A new type of DNA strand scission agent from Piper caninumBioorg. Med. Chem.12(14)3885-3889(2004)