GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC10663 structure
    GC10663Dihydrodaidzein
    CAS: 17238-05-0
    纯度: >98.00%

    An active metabolite of daidzein

  • GC10667 structure
    GC10667Vitamin D3
    CAS: 67-97-0
    纯度: >98.00% / >99.50%

    A precursor to calcitriol

  • GC10672 structure
    GC10672SSR 69071
    CAS: 344930-95-6

    A potent inhibitor of neutrophil elastase

  • GC10675 structure
    GC10675(+,-)-Octopamine HCl
    CAS: 770-05-8
    纯度: >99.00%

    (+,-)-Octopamine HCl是一种与去甲肾上腺素结构相似的生物性单胺类物质，在无脊椎动物体内充当神经激素、神经调节剂和神经递质的角色。

  • GC10694 structure
    GC10694Ramiprilat
    CAS: 87269-97-4

    An ACE inhibitor

  • GC10710 structure
    GC107103-Methyladenine
    CAS: 5142-23-4
    纯度: >97.00% / >96.00% / >98.00%

    3-甲基腺嘌呤是一种经典的自噬抑制剂。

  • GC10730 structure
    GC10730L-Arabitol
    CAS: 7643-75-6

    L-Arabitol 是红薯、鹿莓、蛾豆等食品消耗的潜在生物标志物，还与阿尔茨海默病和 5-磷酸核糖异构酶缺乏症有关。

  • GC10801 structure
    GC10801Disulfiram
    CAS: 97-77-8
    纯度: >99.50%

    An irreversible inhibitor of aldehyde dehydrogenase

  • GC10821 structure
    GC1082111-keto-β-Boswellic Acid
    CAS: 17019-92-0
    纯度: >99.50%

    A 5-LO inhibitor

  • GC10822 structure
    GC10822Clozapine N-oxide (CNO)
    CAS: 34233-69-7
    纯度: >98.00%

    Clozapine N-oxide（CNO）是一种强效的多巴胺拮抗剂，也是一种选择性肌动蛋白M4受体（EC50=11 nM）激动剂。

  • GC10827 structure
    GC10827Oxipurinol
    CAS: 2465-59-0
    纯度: >98.00%

    An inhibitor of xanthine oxidase and active metabolite of allopurinol

  • GC10829 structure
    GC10829Heparin
    CAS: 9005-49-6
    纯度: >98.00%

    肝素是一种高度硫酸化的糖胺聚糖，被广泛用作注射用抗凝剂，在任何已知生物分子中具有最高的负电荷密度。

  • GC10881 structure
    GC10881Gedunin
    CAS: 2753-30-2

    A natural inhibitor of p23 A natural inhibitor of p23

  • GC10897 structure
    GC108972'-Deoxyguanosine
    CAS: 961-07-9
    纯度: >99.50%

    2'-脱氧鸟苷（Deoxyguanosine）由嘌呤核苷鸟嘌呤通过其N9氮与脱氧核糖的C1碳相连。

  • GC10902 structure
    GC10902CVT 10216
    CAS: 1005334-57-5
    纯度: >99.00%

    A selective, reversible ALDH2 inhibitor

  • GC10940 structure
    GC10940PRT 4165
    CAS: 31083-55-3
    纯度: >98.50%

    An inhibitor of PRC1 ubiquitin ligases

  • GC10956 structure
    GC10956Imeglimin hydrochloride
    CAS: 775351-61-6
    纯度: >98.00%

    Imeglimin hydrochloride是一种口服降糖药物，可抑制多药及毒素外排蛋白1（MATE1），IC 50 值为19.24μM。

  • GC10959 structure
    GC10959Boceprevir
    CAS: 394730-60-0
    纯度: >98.00%

    An NS3/4A protease inhibitor

  • GC10977 structure
    GC10977Methylcobalamin
    CAS: 13422-55-4
    纯度: >98.00%

    An analog of vitamin B 12

  • GC10978 structure
    GC10978Terfenadine
    CAS: 50679-08-8
    纯度: >98.00%

    A selective histamine H 1 -receptor antagonist

  • GC10996 structure
    GC109964-Aminobenzoic acid
    CAS: 150-13-0
    纯度: >99.50%

    A biosynthetic intermediate

  • GC10999 structure
    GC10999Avasimibe
    CAS: 166518-60-1
    纯度: >99.50% / >98.00%

    Avasimibe是一种选择性口服酰基辅酶A：胆固醇酰基转移酶（ACAT）抑制剂（IC 50 =12μmol/L）。

  • GC11029 structure
    GC11029Isoprenaline HCl
    CAS: 51-30-9
    纯度: >99.00%

    A β 1 - and β 2 -AR agonist

  • GC11036 structure
    GC11036LCQ-908
    CAS: 956136-95-1
    纯度: >98.00%

    LCQ-908 (LCQ-908) 是一种有效的、选择性的和具有口服活性的二酰基甘油酰基转移酶 1 (DGAT1) 抑制剂。