Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC33642 2,6-Dihydroxybenzoic acid

2,6-二羟基苯甲酸
2,6-Dihydroxybenzoic acid (γ-resorcylic acid, 2-Carboxyresorcinol, 2,6-Resorcylic acid) is a phenolic compound which is known to have poor biological performance such as DPPH scavenging activity and microbial growth inhibition.
GC33643 2,6-Dimethoxybenzoic acid

2,6-二甲氧基苯甲酸
2,6-Dimethoxybenzoic acid is a polyphenol compound found in foods of plant origin.
GC39768 2,6-Dimethylhydroquinone

2,6-二甲基-1,4-苯二酚
2,6-Dimethylhydroquinone 是一种内源性代谢产物。
GC62766 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate

乳清酸
2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate 是一种内源性代谢产物。
GC65461 2,8-Dihydroxyadenine

2,8-二羟基腺嘌呤
2,8-Dihydroxyadenine 是一种内源性代谢物，可导致尿结晶和肾结石的形成。2,8-Dihydroxyadenine 可用于诊断腺嘌呤磷酸核糖转移酶 (APRT) 缺乏症。
GC30697 2-(1-Methyl-1H-imidazol-4-yl)ethan-1-amine 2-(1-Methyl-1H-imidazol-4-yl)ethan-1-amine 是组胺 (Him) 代谢物。
GC49159 2-(1-Piperazinyl)pyrimidine

1-(2-嘧啶基)哌嗪
An α₂-AR antagonist and active metabolite of azapirones
GC38301 2-(1H-Indol-3-yl)ethan-1-ol

色醇; Tryptophol; Indole-3-ethanol
An indole with diverse biological activities
GC62763 2-(2’,3’,4’-Trihydroxybutyl)quinoxaline
2-(2’,3’,4’-Trihydroxybutyl)quinoxaline 是一种食物代谢物，可以由高葡聚糖形成。
GC49330 2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one (hydrochloride)

2-(2-氨乙基)-3-(4-氯苯基)-3-羟基苯并[C]吡咯酮盐酸
A metabolite of mazindol
GC33633 2-(2-Methylbenzamido)acetic acid

2-甲基马尿酸
A metabolite of xylene
GC68504 2-(2-Methylbenzamido)acetic acid-d7

2-甲基马尿酸 d₇
2-(2-Methylbenzamido)acetic acid-d7 是 2-(2-Methylbenzamido)acetic acid 的氘代物。2-(2-Methylbenzamido)acetic acid 为一种代谢物，可以在尿液中检测到。
GC34193 2-(4-Methoxyphenyl)acetic acid (4-Methoxyphenylacetic acid)

对甲氧基苯乙酸,4-Methoxyphenylacetic acid
2-(4-Methoxyphenyl)acetic acid (p-Anisylacetic acid, 4-Methoxyphenylacetic acid) is a 4-O-Methylated catecholamine metabolite found in normal human urine, cerebrospinal fluid and brain tissue.
GC33496 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine)

6-羟基-2-氨甲基嘌呤,N2-methylguanine
2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) (N2-Methylguanine) 是一种修饰的核苷。
GC12964 2-3-Dihydroxybenzoic acid

2,3-二羟基苯甲酸; Catecholcarboxylic acid; NSC 27435
2-3-二羟基苯甲酸是一种在血浆中发现的正常人体苯甲酸代谢物，在服用阿司匹林后水平会升高。
GC39844 2-Acetonaphthone

2-萘乙酮
2-Acetonaphthone 是一种内源性代谢产物。
GC60469 2-Acetyl-3-ethylpyrazine

2-乙酰基-3-乙基吡嗪
2-Acetyl-3-ethylpyrazine是一种内源性代谢产物。
GC30718 2-Amino-1-phenylethanol

2-氨基-1-苯乙醇
2-Amino-1-phenylethanol (2-APE) is a noradrenaline analogue.
GC66717 2-Amino-2-(p-tolyl)acetic acid 2-Amino-2-(p-tolyl)acetic acid 可用于优化叠氮骨架，是 1,3,4- 噻二唑类化合物的中间体。1,3,4- 噻二唑类化合物具有出潜在的抗癌活性，并对谷氨酰胺酶有抑制作用。
GC62769 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

犬尿素
2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是一种内源性代谢产物。
GC60470 2-Amino-5-phenylpyridine

2-氨基-5-苯基吡啶
2-Amino-5-phenylpyridine是一种诱变的杂环芳族胺，是通过蛋白质中的苯丙氨酸热解形成的。2-Amino-5-phenylpyridine存在于烤沙丁鱼等食品中，并且具有潜在的致癌性。
GC62770 2-Amino-5-ureidopentanoic acid

DL-瓜氨酸
L-Citrulline (Citrulline, Cit) is a naturally occurring nonessential amino acid which is the key intermediate in the urea cycle.
GC38260 2-Aminobenzenesulfonic acid

2-氨基苯磺酸
2-Aminobenzenesulfonic acid (Orthanilic acid, O-Aminobenzenesulfonic acid, Aniline-2-sulfonic acid) is a biological acid with roles in benzoate degradation and microbial metabolism in diverse environments.
GC52029 2-Aminoflubendazole

2-氨基氟苯咪唑
A metabolite of flubendazole
GC38321 2-Aminopyrimidin-5-ol

2-氨基-5-羟基嘧啶
2-Aminopyrimidin-5-ol 是一种内源性代谢产物。
GC16403 2-Arachidonoyl Glycerol

2-花生酰基甘油乙腈溶液,2-AG

Endogenous CB₁ and CB₂ receptor agonist
GC60471 2-Benzylsuccinic acid

2-苄基丁二酸,DL-Benzylsuccinic acid
DL-Benzylsuccinic acid (2-benzylbutanedioic acid, Benzylsuccinic acid) is a bacterial xenobiotic metabolite.
GC46539 2-Chloroadenine

2-氯-6-氨基嘌呤
A heterocyclic building block
GC90840 2-Chloroadenosine-5'-O-diphosphate (sodium salt)

2-chloro ADP

ADP的衍生物。
GC11553 2-cyano-Pyrimidine

2-氰基嘧啶
A cathepsin K inhibitor
GC10408 2-D08 An inhibitor of sumoylation
GC40675 2-deoxy-Artemisinin

脱氧青蒿素
An inactive metabolite of artemisinin
GC12850 2-Deoxy-D-ribose

2-脱氧-D-核糖
A reducing sugar
GC11642 2-Deoxyadenosine

2'-脱氧腺苷
2-Deoxyadenosine 是一种核苷腺苷衍生物，与双链 DNA 中的脱氧胸苷 (T) 配对。
GC17478 2-Deoxycytidine

2'-脱氧胞苷; Deoxycytidine; Cytosine deoxyriboside; Deoxyribose cytidine
A deoxyribonucleoside
GC11581 2-Deoxyinosine

2'-脱氧肌苷
A nucleoside form of hypoxanthine
GC13571 2-Deoxyuridine

2'-脱氧尿苷; 2-脱氧尿苷
A pyrimidine nucleoside
GC60472 2-Ethylpyrazine

2-乙基吡嗪
2-Ethylpyrazine是一种内源性代谢产物。
GC31632 2-Furoic acid (Furan-2-carboxylic acid)

糠酸; Furan-2-carboxylic acid

2-Furoic acid (2-Furancarboxylic acid, Pyromucic acid, 2-Carboxyfuran, α-furancarboxylic acid, α-furoic acid) is an organic compound most widely found in food products as a preservative and a flavoring agent.
GC33645 2-Guanidinoacetic acid

胍基乙酸,Guanidinoacetic acid
A metabolite of glycine and precursor in the biosynthesis of creatine
GC11804 2-Guanidinoethylmercaptosuccinic Acid

GEMSA
A carboxypeptidase inhibitor
GC12545 2-HBA

Bis(2-hydroxybenzylidene)acetone
An indirect inhibitor of Keap1-Nrf2 interactions
GC35090 2-Hydroxy atorvastatin calcium salt

2-羟基阿托伐他汀钙盐
An active metabolite of atorvastatin
GC60474 2-Hydroxy atorvastatin lactone

O-羟基阿伐他汀内酯
2-Hydroxyatorvastatinlactone是Atorvastatin的代谢产物。2-Hydroxyatorvastatinlactone是一种口服活性HMG-CoA还原酶抑制剂，具有有效降低血脂的能力。
GC31544 2-Hydroxy-2-methylbutanoic acid

2-羟基-2-甲基丁酸
2-Hydroxy-2-methylbutyric acid is an unusual metabolite found in the urine of patients with 2-hydroxyglutaric aciduria and maple syrup urine disease. 2-Hydroxy-2-methylbutyric acid is also a secondary metabolite found in human urine after exposure to the gasoline additive tert-amyl-Me-ether (TAME).
GC38281 2-Hydroxy-2-phenylacetic acid

扁桃酸,(±)-Mandelic acid; DL-Mandelic acid
2-羟基-2-苯乙酸（(±)-2-羟基-2-苯乙酸）是一种α-羟基羧酸，已广泛用作医药和精细化学品的中间体。
GC31222 2-Hydroxy-3-methylbutanoic acid

2-羟基-3-甲基丁酸
2-Hydroxy-3-methylbutanoic acid (3-Methyl-2-hydroxybutyric acid, 2-Hydroxyisopentanoic acid, 2-Oxyisovaleric acid) is a metabolite found in the urine of patients with phenylketonuria, methylmalonic acidemia, propionic acidemia, 3-ketothiolase deficiency, isovaleric acidemia, 3-methylcrotonylglycemia, 3-hydroxy-3-methylglutaric acidemia, multiple carboxylase deficiency, glutaric aciduria, ornithine transcarbamylase deficiency, glyceroluria, tyrosinemia type I, galactosemia, and maple syrup urine disease.
GC30564 2-Hydroxy-4-methoxybenzaldehyde

2-羟基-4-甲氧基苯甲醛
A phenol with diverse biological activities
GC60475 2-Hydroxy-4-methylbenzaldehyde

2-羟基-4-甲基苯甲醛
2-Hydroxy-4-methylbenzaldehyde是一种内源性代谢产物。
GC30612 2-Hydroxyadipic acid

2-羟基己二酸二钠盐
A dicarboxylic fatty acid