Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC11070Dehydroepiandrosterone (DHEA)CAS: 53-43-0纯度: >99.00%
脱氢表雄酮 (DHEA) 及其硫酸酯 DHEAS 共同代表了人体内最丰富的类固醇激素。
- GC11222MethylthioadenosineCAS: 2457-80-9纯度: >99.50% / >97.00%
Methylthioadenosine是多胺生物合成过程中由 S-腺苷甲硫氨酸(SAMe)产生的含硫腺嘌呤核苷。Methylthioadenosine常用于结肠炎、肝病和各种癌症疾病的研究。
- GC11236[Leu5]-EnkephalinCAS: 58822-25-6纯度: >99.50%
[Leu5]-Enkephalin是一种通过与阿片受体结合以调节疼痛感知和情绪的内源性δ阿片受体激动剂。
- GC11268L-ThyroxineCAS: 51-48-9纯度: >98.00%
L-Thyroxine是一种合成甲状腺激素，可模拟甲状腺分泌的天然甲状腺素，对调节新陈代谢、促进生长发育等起着关键作用。L-Thyroxine常用于治疗甲状腺功能减退症及其他甲状腺相关疾病。
- GC11344Eicosapentaenoic AcidCAS: 10417-94-4纯度: >98.00% / >97.00%
Eicosapentaenoic Acid（EPA）二十碳五烯酸是一种具有口服活性的omega-3（ω-3）长链多不饱和脂肪酸（PUFA），是前列腺素3、血栓素3和白三烯5类二十烷酸的前体。
- GC11357Dihomo-γ-Linolenic AcidCAS: 1783-84-2纯度: >98.00% / >98.00%% / >99.00%
ω-6 fatty acid intermediate
- GC11459Xanthurenic acidCAS: 59-00-7纯度: >99.50% / >98.00%
Xanthurenic acid是一种内源性II组代谢型谷氨酸受体激动剂，参与丘脑的感觉传递。
- GC11463MK-5172 sodium saltCAS: 1425038-27-2
MK-5172 sodium salt (MK-5172 sodium salt) 是丙型肝炎病毒 NS3/4a 蛋白酶的选择性抑制剂，对基因型和耐药变异具有广泛的活性，Kis 为 0.01 nM (gt1b)、0.01 nM (gt1a)、0.08 nM (gt2a)、0.15 nM (gt2b)、0.90 nM (gt3a)。
- GC11528Orotic acidCAS: 65-86-1纯度: >98.00%
乳清酸 (6-Carboxyuracil) 是嘧啶核苷酸和 RNA 生物合成的前体，从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放出来，通过细胞质 UMP 合酶转化为 UMP。
- GC11532LonidamineCAS: 50264-69-2纯度: >99.00%
Lonidamine是一种己糖激酶、线粒体丙酮酸载体（在分离的大鼠肝脏线粒体中Ki为2.5μM）和质膜单羧酸转运蛋白抑制剂，同时还抑制线粒体复合物 II。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC11038 | MMP-2/MMP-9 Inhibitor I | 193807-58-8 | - | |
An inhibitor of MMP-2 and MMP-9 | ||||
| GC11064 | Spermine tetrahydrochloride | 306-67-2 | >99.00% | |
A natural polyamine | ||||
| GC11065 | Pifithrin-μ | 64984-31-2 | >98.00% | |
Pifithrin-μ是p53和HSP70的抑制剂。 | ||||
| GC11070 | Dehydroepiandrosterone (DHEA) | 53-43-0 | >99.00% | |
脱氢表雄酮 (DHEA) 及其硫酸酯 DHEAS 共同代表了人体内最丰富的类固醇激素。 | ||||
| GC11139 | 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PC | 35418-59-8 | >98.00% | |
A phospholipid | ||||
| GC11155 | Omeprazole sulfone | 88546-55-8 | - | |
The major metabolite of omeprazole | ||||
| GC11195 | Sarcosine | 107-97-1 | >98.00% | |
An intermediate in the biosynthesis of glycine | ||||
| GC11222 | Methylthioadenosine | 2457-80-9 | >99.50% / >97.00% | |
Methylthioadenosine是多胺生物合成过程中由 S-腺苷甲硫氨酸(SAMe)产生的含硫腺嘌呤核苷。Methylthioadenosine常用于结肠炎、肝病和各种癌症疾病的研究。 | ||||
| GC11228 | Benazepril | 86541-75-5 | >98.00% | |
贝那普利，一种血管紧张素转换酶抑制剂，是一种用于治疗高血压的药物。 | ||||
| GC11236 | [Leu5]-Enkephalin | 58822-25-6 | >99.50% | |
[Leu5]-Enkephalin是一种通过与阿片受体结合以调节疼痛感知和情绪的内源性δ阿片受体激动剂。 | ||||
| GC11242 | Calcium Gluceptate | 17140-60-2 | - | |
葡萄糖酸钙是一种内源性代谢物。 | ||||
| GC11266 | Lisinopril dihydrate | 83915-83-7 | >99.50% | |
An ACE inhibitor | ||||
| GC11268 | L-Thyroxine | 51-48-9 | >98.00% | |
L-Thyroxine是一种合成甲状腺激素，可模拟甲状腺分泌的天然甲状腺素，对调节新陈代谢、促进生长发育等起着关键作用。L-Thyroxine常用于治疗甲状腺功能减退症及其他甲状腺相关疾病。 | ||||
| GC11270 | 4-Hydroxybenzoic acid | 99-96-7 | >98.00% | |
A phenolic acid | ||||
| GC11272 | Phenylephrine HCl | 61-76-7 | >99.50% | |
Phenylephrine HCl（盐酸去氧肾上腺素）是一种选择性的α1-肾上腺素能受体激动剂。 | ||||
| GC11282 | β-Estradiol | 50-28-2 | >99.50% | |
The major premenopausal estrogen | ||||
| GC11344 | Eicosapentaenoic Acid | 10417-94-4 | >98.00% / >97.00% | |
Eicosapentaenoic Acid（EPA）二十碳五烯酸是一种具有口服活性的omega-3（ω-3）长链多不饱和脂肪酸（PUFA），是前列腺素3、血栓素3和白三烯5类二十烷酸的前体。 | ||||
| GC11357 | Dihomo-γ-Linolenic Acid | 1783-84-2 | >98.00% / >98.00%% / >99.00% | |
ω-6 fatty acid intermediate | ||||
| GC11445 | YH239-EE | 1364488-67-4 | >99.50% | |
A prodrug form of YH 239 | ||||
| GC11459 | Xanthurenic acid | 59-00-7 | >99.50% / >98.00% | |
Xanthurenic acid是一种内源性II组代谢型谷氨酸受体激动剂，参与丘脑的感觉传递。 | ||||
| GC11463 | MK-5172 sodium salt | 1425038-27-2 | - | |
MK-5172 sodium salt (MK-5172 sodium salt) 是丙型肝炎病毒 NS3/4a 蛋白酶的选择性抑制剂，对基因型和耐药变异具有广泛的活性，Kis 为 0.01 nM (gt1b)、0.01 nM (gt1a)、0.08 nM (gt2a)、0.15 nM (gt2b)、0.90 nM (gt3a)。 | ||||
| GC11475 | AZD7687 | 1166827-44-6 | >99.00% | |
AZD7687 是一种有效的、选择性的、可逆的和具有口服活性的 diacylglycerol acyltransferase 1 (DGAT1) 抑制剂，对人 DGAT1 的 IC50 为 80 nM。 | ||||
| GC11528 | Orotic acid | 65-86-1 | >98.00% | |
乳清酸 (6-Carboxyuracil) 是嘧啶核苷酸和 RNA 生物合成的前体，从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放出来，通过细胞质 UMP 合酶转化为 UMP。 | ||||
| GC11532 | Lonidamine | 50264-69-2 | >99.00% | |
Lonidamine是一种己糖激酶、线粒体丙酮酸载体（在分离的大鼠肝脏线粒体中Ki为2.5μM）和质膜单羧酸转运蛋白抑制剂，同时还抑制线粒体复合物 II。 | ||||