1-Stearoyl-2-arachidonoyl-sn-glycero-3-PC (SAPC) is a phospholipid containing stearic acid and arachidonic acid at the sn-1 and sn-2 positions, respectively. It is a component of LDL and has been found in human stenotic aortic valves and atherosclerotic plaques.[1],[2] Levels of SAPC are increased in the subepithelial invasive region compared to the superficial region of tumor tissue samples from patients with superficial-type pharyngeal squamous cell carcinoma.[3] SAPC unilamellar vesicles have been used as substrates to quantify the activity of secretory phospholipase A2 (sPLA2) in the presence or absence of inhibitors.[4] SAPC has also been used in the formation of lipid bilayers to study the effects of lipid composition on bilayer phase transitions.[5]
Reference
[1]. Milne, G.L., Seal, J.R., Havrilla, C.M., et al. Identification and analysis of products formed from phospholipids in the free radical oxidation of human low density lipoproteins. J. Lipid Res. 46(2), 307-319 (2005).
[2]. Lehti, S., Käkelä, R., Hörkkö, S., et al. Modified lipoprotein-derived lipid particles accumulate in human stenotic aortic valves. PLoS One 8(6), e65810 (2013).
[3]. Ishikawa, S., Tateya, I., Hayasaka, T., et al. The distribution of phosphatidylcholine species in superficial-type pharyngeal carcinoma. Biomed. Res. Int. 5387913, (2017).
[4]. Schebb, N.H., Falck, D., Faber, H., et al. Fast method for monitoring phospholipase A2 activity by liquid chromatography-electrospray ionization mass spectrometry. J. Chromatogr. A 1216(27), 5249-5255 (2009).
[5]. Tada, K., Goto, M., Tamai, N., et al. Pressure effect on the bilayer phase transition of asymmetric lipids with an unsaturated acyl chain. Ann. N.Y. Acad. Sci. 1189(1), 77-85 (2010).