Tis108 is a triazole-type strigolactone (SL)-biosynthesis inhibitor[1].
TIS108 (3μM) increased the number of branches in Arabidopsis and inhibited root hair elongation[1].Tis108 TIS108 (0, 0.2μM, 1μM and 5μM) has been confirmed to enhance the shoot regeneration capacity of woody plants in M26 material (Malus pumila Mill., a type of apple rootstock)[2]. Tis108 (10μM; 5, 10 and 30 days) promotes stem growth and development of cherry rootstocks and increases the size of cortical cells in cherry rootstocks[3].Treatment of rice seedlings with Tis108 (10-100nM) reduces the levels of strigolactones (SL) in both roots and root exudates in a concentration-dependent manner. The root exudates from Tis108 (1μM)-treated rice seedlings have a weaker stimulatory effect on the germination of Striga compared to those from control plants[4]. Tis108 (3μM; 3 weeks) decreased cotton resistance to Verticillium wilt[5].
References:
[1] Ito S, Umehara M, Hanada A, Yamaguchi S, Asami T. Effects of strigolactone-biosynthesis inhibitor TIS108 on Arabidopsis. Plant Signal Behav. 2013 May;8(5):e24193.
[2] Asghar S, Xiong Y, Che M, Fan X, Li H, Wang Y, Xu X, Li W, Han Z. Transcriptome analysis reveals the effects of strigolactone on shoot regeneration of apple. Plant Cell Rep. 2022 Jul;41(7):1613-1626.
[3] Liu X, Xu Y, Sun W, Wang J, Gao Y, Wang L, Xu W, Wang S, Jiu S, Zhang C. Strigolactones modulate stem length and diameter of cherry rootstocks through interaction with other hormone signaling pathways. Front Plant Sci. 2023 Feb 9;14:1092654.
[4] Ito S, Umehara M, Hanada A, Kitahata N, Hayase H, Yamaguchi S, Asami T. Effects of triazole derivatives on strigolactone levels and growth retardation in rice. PLoS One. 2011;6(7):e21723.
[5] Yi F, Song A, Cheng K, Liu J, Wang C, Shao L, Wu S, Wang P, Zhu J, Liang Z, Chang Y, Chu Z, Cai C, Zhang X, Wang P, Chen A, Xu J, Burritt DJ, Herrera-Estrella L, Tran LP, Li W, Cai Y. Strigolactones positively regulate Verticillium wilt resistance in cotton via crosstalk with other hormones. Plant Physiol. 2023 May 31;192(2):945-966.
Tis108是一种三唑类三唑类独脚金内酯（SL）生物合成抑制剂[1]。
Tis108（3μM）增加了拟南芥的分枝数量并抑制了根毛的伸长[1]。Tis108(0, 0.2 μM, 1μM和5μM)已被证实可以提高M26材料(苹果砧木, Malus pumila Mill.)中木本植物的茎段再生能力[2]。Tis108(10μM; 5, 10和30天)促进了樱桃砧木的茎生长和发育，并增加了樱桃砧木皮层细胞的大小[3]。用Tis108(10-100nM)处理水稻幼苗会以浓度依赖的方式降低根和根分泌物中的油菜素内酯（SL）水平。与对照植株相比，经1μM Tis108处理的水稻幼苗的根分泌物对独脚金萌发的刺激作用较弱[4]。Tis108(3μM; 3周)降低了棉花对黄萎病的抗性[5]。